Cited by 1,633Nitric Oxide and Endothelin EffectsPhosphodiesterase function and regulationCardiovascular Health and Disease Prevention

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Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

Ignarro, L J, Lippton, H, Edwards, J C, Baricos, W H, Hyman, A L, Kadowitz, P J, Gruetter, C A·1981·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)32738-2

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Background
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Background
Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds
Pereira, A., Paulo, M., Araújo, A. V., Rodrigues, G. J., & Bendhack, L. M. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500084 · Cited by 44
“In early in vitro studies, as reported by Furchgott and Bhadrakom (48), high NO2- concentrations (≈100 μM) were typically used to induce aortic ring relaxation or to activate purified sGC, the enzyme that catalyzes the conversion of guanosine triphosphate (GTP) to cGMP and that mediates NO vasorelaxation (49).”
Background
Nitric Oxide Donors Protect Cultured Rat Astrocytes From 1-Methyl-4-Phenylpyridinium-Induced Toxicity
Tsai, M. J., & Lee, E. H. Y. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00329-8 · Cited by 40
Interactive role of nitric oxide and superoxide anion in neutrophil-mediated endothelial cell injury
Kausalya, S., & Nath, J. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.2.185 · Cited by 40
“Because NO has been associated with the inhibition of platelet adhesion to EC [24], we evaluated the role of NO in the adhesion of PMN to EC by addition of 1025 M S-nitroso-N-acetylpenicillamine (SNAP), a S-nitrosothiol compound and a stable NO donor [25], to the Fig.”
Method
Nitric Oxide in the Autonomic and Enteric Nervous Systems
Rand, M. J., & Li, C. G. (1995) · Elsevier eBooks · doi:10.1016/b978-012721985-1/50014-9 · Cited by 40
Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat
Casey, D. B., Badejo, A. M., Dhaliwal, J. S., Sikora, J. L., Fokin, A., Golwala, N. H., Greco, A. J., Murthy, S. N., Nossaman, B. D., Hyman, A. L., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00181.2009 · Cited by 37
Self-citation
EFFECTS OF HYDROXOCOBALAMIN AND HAEMOGLOBIN ON NO‐MEDIATED RELAXATIONS IN THE RAT ANOCOCCYGEUS MUSCLE
Li, C. G., & Rand, M. J. (1993) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1993.tb01645.x · Cited by 38
Nitric oxide generation, tachyphylaxis and cross-tachyphylaxis from nitrovasodilators in vivo
Agvald, P., Adding, C., Gustafsson, L. E., & Persson, M. G. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00720-7 · Cited by 38
The involvement of catalytic site thiol groups in the activation of soluble guanylate cyclase by sodium nitroprusside
Kamisaki, Y., Waldman, S. A., & Murad, F. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90380-2 · Cited by 39
Modification of cysteine residues within Go and other neuronal proteins by exposure to nitric oxide
Hess, D. T., Lin, L., Freeman, J. A., & Norden, J. J. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90028-0 · Cited by 39

Authors: Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A.
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1981-09
Volume: 218
Issue: 3
Pages: 739-749
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)32738-2
OpenAlex: W1907994445
Cited by: 1,633
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 14 · 2018: 23 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 27
FWCI: 18.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: vasorelaxation, organic nitrates, nitrite, sodium nitroprusside, nitric oxide, S-nitrosothiols, guanylate cyclase activation, cyclic GMP, nitroglycerin, isosorbide dinitrate, PETN, amyl nitrite, sodium nitrite, sulfhydryl groups, coronary arteries
MeSH terms: Animals, Biotransformation, Cats, Cattle, Coronary Vessels, Enzyme Activation, Female, Ferricyanides, Guanylate Cyclase, Hemodynamics, Male, Nitrates, Nitric Oxide, Nitrites, Nitroprusside, Nitroso Compounds, Vasodilator Agents, In Vitro Techniques

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Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

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