Cited by 137Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat

Kalivas, P W, Duffy, P, Latimer, L G·1987·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)39170-6

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Abstract

Corticotropin-releasing factor (CRF) is thought to have a neurotransmitter function in the mammalian central nervous system. The release of CRF into the hypothalamic-hypophyseal portal system in response to stress is known, and it has been suggested that CRF may function elsewhere in the central nervous system to promote stress-induced physiological and behavioral changes. Acute stress has been shown to activate dopamine (DA) neurons in the ventral tegmental area (VTA) that project to the prefrontal cortex. To determine whether CRF may act in the VTA to activate the mesocortical or mesolimbic DA systems, it was injected into the VTA of rats, and changes in spontaneous motor behavior and DA metabolism were measured. Intra-VTA injection of CRF produced a dose-dependent increase in horizontal and vertical photocell counts with a minimal effective dose of 0.01 and 0.1 nmol, respectively. In contrast, the minimal effective dose for CRF-stimulated motor behavior after injection into the lateral ventricles was 0.3 nmol for horizontal activity. Furthermore, in the open field, the behavioral profile of CRF (0.3 nmol) given intra-VTA differed from that observed after intraventricular injection. The motor stimulant effect of intra-VTA CRF was not blocked by pretreatment with the DA receptor antagonist haloperidol. After intra-VTA injection, CRF produced a dose-dependent decrease in DA metabolism in the prefrontal cortex. The decrease in DA metabolism in the prefrontal cortex was present at 30 and 60 min but not at 120 min after injection, and in the nucleus accumbens DA metabolism was increased only at 60 min after injection.(ABSTRACT TRUNCATED AT 250 WORDS)

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Pucci, M., Bonaventura, M. V. M. D., Giusepponi, M. E., Romano, A., Filaferro, M., Maccarrone, M., Ciccocioppo, R., Cifani, C., & D’Addario, C. (2015) · Addiction Biology · doi:10.1111/adb.12303 · Cited by 42
“Of interest was the consistent increase between the gene expression changes and the levels of both CRF and CRF-1R in the VTA of rats showing binge-eating behavior, whereas no alterations where found in the hypothalamus (Figure S3).”
BackgroundInfluential
Evidence that corticotropin-releasing factor within the extended amygdala mediates the activation of tryptophan hydroxylase produced by sound stress in the rat
Boadle‐Biber, M. C., Singh, V. B., Corley, K. C., Phan, T.-H., & Dilts, R. P. (1993) · Brain Research · doi:10.1016/0006-8993(93)90944-i · Cited by 40
Corticotropin releasing factor and neuroplasticity in cocaine addiction
Corominas, M., Roncero, C., & Casas, M. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.11.005 · Cited by 39
“…effectors of stress, corticotropin releasing factor (CRF), facilitates addiction by increasing locomotion (Cador et al. 1992, 1993; Erb et al. 2003; Kalivas et al. 1987), mediating the response to conditioned stimuli (Lu et al. 2001), and facilitating relapse during abstinence (Erb et al. 1998;…”
Influential
The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.
Harro, J., Tõnissaar, M., & Eller, M. (2001) · Neuropeptides · doi:10.1054/npep.2001.0851 · Cited by 42
Stress‐induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei
Esparza, M. A., Bollati, F. A., García‐Keller, C., Virgolini, M. B., Lopez, L. M., Brusco, A., Shen, H., Kalivas, P. W., & Cancela, L. M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08239.x · Cited by 36
“…within the ventral tegmental area (VTA; Tagliaferro & Morales, 2008), and injection of CRF directly into the VTA increases locomotor activity (Kalivas et al., 1987), while injection of CRF antagonists inhibits stress-induced reinstatement of cocaine-seeking (Wang et al., 2005, 2007) as well…”
Background
Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats
Goeders, N. E., & Guerin, G. F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.07.005 · Cited by 35
“Accordingly, the administration of CRF directly into the VTA results in a time-dependent decrease in prefrontal cortical dopamine metabolism with an increase in dopamine turnover in the nucleus accumbens (Kalivas et al., 1987).”
Cholecystokinin Modulation of Mesolimbic Dopamine Function: Regulation of Motivated Behaviour
Rotzinger, S., Bush, D. E. A., & Vaccarino, F. J. (2002) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2002.910620.x · Cited by 33
The neuroanatomic complexity of the CRF and DA systems and their interface: What we still don’t know
Kelly, E. A., & Fudge, J. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.014 · Cited by 31
Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats
Knapp, D. J., Overstreet, D. H., Huang, M. M., Wills, T. A., Whitman, B. A., Angel, R. A., Sinnett, S. E., & Breese, G. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2366-5 · Cited by 32
“Likewise, local injection of CRF into the Amyg, DRN, or VTA can also have an acute activating action (Hiroi and Neumaier 2009; Kalivas et al. 1987; Lack et al. 2008; Lee and Tsai 1989; Meloni et al. 2008; Wand 2005).”
Background
Peripheral but not intracerebroventricular corticotropin-releasing hormone (CRH) produces antinociception which is not opioid mediated
Ayesta, F. J. A., & Nikolarakis, K. E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91667-3 · Cited by 31
Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions
Bryce, C. A., & Floresco, S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05244-w · Cited by 29
Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF
Leonard, M. Z., DeBold, J. F., & Miczek, K. A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4677-7 · Cited by 28
“CRF doses were selected based on previous in vivo studies in rats (Kalivas et al. 1987; Blacktop et al. 2011; Wanat et al. 2013).”
Method
A study of the lasting effects of cocaine pre-exposure on anxiety-like behaviors under baseline conditions and in response to central injections of corticotropin-releasing factor
Erb, S. M., Kayyali, H., & Romero, K. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.08.002 · Cited by 28
PYY‐preferring receptor in the dorsal vagal complex and its involvement in PYY stimulation of gastric acid secretion in rats
Yang, H., Li, W. P., Reeve, J. R., Rivier, J., & Taché, Y. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701767 · Cited by 28
“…receptor proteins has been carried out (Bard et al., 1995; Nakamura et al., 1995; Gehlert et al., 1996a,b; Gerald et al., 1996; Gregor et al., 1996a,b; Hu et al., 1996; Weinberg et al., 1996) except for the Y3 and PYY-preferring receptor (Kalivas et al., 1987; Mannon et al., 1993; Gehlert, 1994).”
Background
CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety
Pleil, K. E., & Skelly, M. J. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.01.007 · Cited by 29
Differential Distribution of Corticotropin-Releasing Hormone Immunoreactive Axons in Monoaminergic Nuclei of the Human Brainstem
Austin, M. C. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00083-3 · Cited by 27
Social interaction reward in rats has anti‐stress effects
Lemos, C., Salti, A., Amaral, I. M., Fontebasso, V., Singewald, N., Dechant, G., Hofer, A., & Rawas, R. E. (2020) · Addiction Biology · doi:10.1111/adb.12878 · Cited by 26
“Human/rat CRF, alpha-helical CRF (9-41), and SB203580 were”
Low doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior
Cole, B. J., & Koob, G. F. (1989) · Psychopharmacology · doi:10.1007/bf00634448 · Cited by 26
Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis
Boehm, S. L., Reed, C. L., McKinnon, C. S., & Phillips, T. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1000-y · Cited by 26
Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System
Ronan, P. J., & Summers, C. H. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00006-5 · Cited by 24
Effects of a Typical and an Atypical Antipsychotic on the Disruption of Prepulse Inhibition Caused by Corticotropin-Releasing Factor and by Rat Strain.
Conti, L. H., Costill, J. E., Flynn, S. P., & Tayler, J. E. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.1052 · Cited by 25
Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioural responses in rats
Lowry, C. A., Lowry, C. A., Hale, M. W., Lowry, C. A., Hale, M. W., Plant, A., Windle, R. J., Lowry, C. A., Hale, M. W., Plant, A., et al. (2008) · Stress · doi:10.1080/10253890802309861 · Cited by 25
“…and noradrenergic systems may contribute to CRF-induced behavioural arousal, elegant work has established that CRF-induced motor activation is not dependent upon activation of mesolimbic dopaminergic systems (Koob et al. 1984; Swerdlow and Koob 1985; Swerdlow et al. 1986; Kalivas et al. 1987).”
Background
Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking
Vranjkovic, O., Newenhizen, E. C. V., Nordness, M. E., Blacktop, J. M., Urbanik, L. A., Mathy, J. C., McReynolds, J. R., Miller, A. M., Doncheck, E. M., Kloehn, T. M., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2080-18.2018 · Cited by 26
“Although studies examining the regulation of mesocortical dopamine by VTA CRF have produced mixed results (Kalivas et al., 1987), reports that intracerebroventricular CRF increases dopaminergic neurotransmission in the prefrontal cortex (Dunn and Berridge, 1987; Lavicky and Dunn, 1993) and that CRF…”
Result
Studies on the interaction between ICV effects of CRF and CNS noradrenaline depletion
Bakke, H. K., Bogsnes, A., & Murison, R. C. C. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90379-i · Cited by 23
Corticotropin-releasing hormone receptor blockade fails to alter stress-evoked catecholamine release in prefrontal cortex of control or chronically stressed rats
Murphy, E., Sved, A. F., & Finlay, J. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00565-1 · Cited by 23
Area-specific analysis of the distribution of hypothalamic neurons projecting to the rat ventral tegmental area, with special reference to the GABAergic and glutamatergic efferents
Kalló, I., Molnár, C. S., Szöke, S., Fekete, C., Hrabovszky, E., & Liposits, Z. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00112 · Cited by 21
“, 1989), in the NAc shell (Kalivas et al., 1987) and in the basolateral amygdala (Inglis and Moghaddam, 1999).”
Background
Behavioral and hormonal regulation of expression of the clock protein, PER2, in the central extended amygdala
Amir, S., & Stewart, J. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.003 · Cited by 21
Alterations in local cerebral glucose utilization following central administration of corticotropin‐releaseing factor in rats
Sharkey, J., Appel, N. M., & Souza, E. B. D. (1989) · Synapse · doi:10.1002/syn.890040109 · Cited by 21
“In support of the latter hypothesis, CRF administration has been reported to alter dopamine turnover in nucleus accumbens and prefrontal cortex (Dunn and Berridge, 1985; Kalivas et al., 1987) and has been shown to increase the firing rate of noradrenergic neurons in locus coeruleus (Valentino et al.”
Background
A role for corticotropin-releasing factor in the long-term expression of behavioral sensitization to cocaine
Erb, S. M., & Brown, Z. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.024 · Cited by 20

Authors: Kalivas, P. W., Duffy, P., & Latimer, L. G.
Affiliations: Washington State University (US)
ORCID: Kalivas, P W
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1987-09
Volume: 242
Issue: 3
Pages: 757-763
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)39170-6
OpenAlex: W2272340543
Cited by: 137
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 6
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Funders: National Institute of Mental Health (MH-40817)
National Institute on Drug Abuse (DA03906)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: corticotropin-releasing factor, ventral tegmental area, dopamine metabolism, mesolimbic dopamine system, mesocortical dopamine system, motor stimulation, prefrontal cortex, nucleus accumbens, stress, haloperidol, intraventricular injection
MeSH terms: Animals, Corticotropin-Releasing Hormone, Dopamine, Dose-Response Relationship, Drug, Frontal Lobe, Haloperidol, Male, Motor Activity, Naloxone, Rats, Inbred Strains, Tegmentum Mesencephali, Rats

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Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat

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