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Cited by 18Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Altered cortico-striatal crosstalk underlies object recognition memory deficits in the sub-chronic phencyclidine model of schizophrenia

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Asif-Malik, Aman, Dautan, Daniel, Young, Andrew M. J., Gerdjikov, Todor V.·2017·Brain Structure and Function
DOI 10.1007/s00429-017-1393-3PMC PMC5585296
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Abstract

The neural mechanisms underlying cognitive deficits in schizophrenia are poorly understood. Sub-chronic treatment with the NMDA antagonist phencyclidine (PCP) produces cognitive abnormalities in rodents that reliably model aspects of the neurocognitive alterations observed in schizophrenia. Given that network activity across regions encompassing medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) plays a significant role in motivational and cognitive tasks, we measured activity across cortico-striatal pathways in PCP-treated rats to characterize neural enabling and encoding of task performance in a novel object recognition task. We found that PCP treatment impaired task performance and concurrently (1) reduced tonic NAc neuronal activity, (2) desynchronized cross-activation of mPFC and NAc neurons, and (3) prevented the increase in mPFC and NAc neural activity associated with the exploration of a novel object in relation to a familiar object. Taken together, these observations reveal key neuronal and network-level adaptations underlying PCP-induced cognitive deficits, which may contribute to the emergence of cognitive abnormalities in schizophrenia.

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Cited by

Sorted by citations

Authors
Asif-Malik, A., Dautan, D., Young, A. M. J., & Gerdjikov, T. V.
Affiliations
  • University of Leicester (GB)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Gerdjikov, Todor V.
ORCID
Venue
Brain Structure and Function
Publisher
Springer Science and Business Media LLC
Published
2017-03-14
Volume
222
Issue
7
Pages
3179-3190
ISSN
  • 1863-2653 (ISSN-L)
  • 1863-2661
DOI
10.1007/s00429-017-1393-3
PMC
PMC5585296
OpenAlex
W2597309578
Cited by
18
References
4
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2017: 1
FWCI
1.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Structure and Function (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Leicester Research Archive (University of Leicester) (submittedVersion, cc-by)
Funders
  • Daphne Jackson Trust
  • Rosetrees Trust
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
schizophrenia, phencyclidine, NMDA receptor antagonists, novel object recognition memory, corticostriatal network, medial prefrontal cortex, nucleus accumbens, tonic neuronal activity, cognitive impairment
MeSH terms
Action Potentials, Animals, Disease Models, Animal, Female, Hallucinogens, Memory Disorders, Neural Pathways, Neurons, Nucleus Accumbens, Phencyclidine, Schizophrenia, Prefrontal Cortex, Recognition, Psychology, Rats

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