The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Adrenocortical Carcinoma: Diagnosis, Evaluation and Treatment
Abstract
PURPOSE: We describe the presenting features, imaging methods, prognosis of and treatment approach to adrenocortical carcinoma. MATERIALS AND METHODS: A comprehensive literature review of adrenal carcinoma was performed using PubMed and a review of current urology, oncology, radiology and pathology journals. RESULTS: The incidence of adrenocortical tumors has been reported to be approximately 2/1 x 10(6) population, although this value may be an underestimate due to an increase in the incidence of unexpected adrenal masses or incidentalomas in the last decade. There has been a bimodal age incidence of adrenal carcinoma with most patients 40 to 50 years old in the studies reviewed. Overall the prevalence of adrenal tumors was slightly higher in females with most presenting with Cushing's syndrome. Of the 602 adrenal tumors reviewed 62% were functional and 38% were nonfunctional. Modern day imaging, including ultrasound, computerized tomography (CT) and magnetic resonance imaging, have greatly improved the diagnosis and staging of adrenal carcinoma. Surgical removal of a localized tumor and absent metastatic disease were associated with improved survival. Medical therapy with mitotane and its successors in patients with metastatic disease appear to be of little benefit for improving survival. CONCLUSIONS: Based on a review of the literature we recommend that hormone levels should be determined in symptomatic and asymptomatic patients with adrenal masses. CT should be the first study done to define an adrenal mass. All solid incidentalomas greater than 5 cm. on CT or magnetic resonance imaging should be removed surgically. The best chance of survival was achieved by surgical extirpation with the value of adjuvant therapy yet to be determined.
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In the citing paper
“Between 40% and 60% of ACCs are functional and may present with symptoms of hormonal hypersecretion (126,127,128,129), most commonly with Cushing’s syndrome (estimated 45%).”
From Adrenal incidentaloma (2020) · cites this paper as [127]
In the citing paper
“Feminization and hyperaldosteronism are rare occurring in <10% of cases (127,130).”
From Adrenal incidentaloma (2020) · cites this paper as [127]
In the citing paper
“Primary ACC is rare, with an estimated population incidence of 1 to 2 per million per year (126,127).”
From Adrenal incidentaloma (2020) · cites this paper as [127]
In the citing paper
“most commonly with Cushing’s syndrome (estimated 45%).”
From Adrenal incidentaloma (2020) · cites this paper as [127]
In the citing paper
“ACC is rare and aggressive and can occur at any age. However, peak incidence tends to be before the age of 5 and between the ages of 40 and 60 years of age (126,127).”
From Adrenal incidentaloma (2020) · cites this paper as [127]
Citations
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LAPAROSCOPIC ADRENALECTOMY: THE PREFERRED CHOICE? A COMPARISON TO OPEN ADRENALECTOMY
Winfield, H. N., Hamilton, B. D., Bravo, E. L., & Novick, A. C. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62884-2 · Cited by 175
Research works printed but not linked: 1
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Cited by
Sorted by citations
The clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781
Fassnacht, M., Johanssen, S., Quinkler, M., Bucsky, P., Willenberg, H. S., Beuschlein, F., Terzolo, M., Mueller, H., Hahner, S., Allolio, B., et al. (2009) · Cancer · doi:10.1002/cncr.24030 · Cited by 695
Zeiger, M. A., Thompson, G. B., Duh, Q.-Y., Hamrahian, A. H., Angelos, P., Elaraj, D., Fishman, E., Kharlip, J., Zeiger, M. A., Thompson, G. B., et al. (2009) · Endocrine Practice · doi:10.4158/ep.15.s1.1 · Cited by 499
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347
“Feminization and hyperaldosteronism are rare occurring in <10% of cases (127,130).”
BackgroundInfluentialAdrenal mass imaging with multidetector CT: pathologic conditions, pearls, and pitfalls
Johnson, P. T., Horton, K. M., & Fishman, E. K. (2009) · Radiographics · doi:10.1148/rg.295095027 · Cited by 238
Metadata
- Authors
- NG, L., & LIBERTINO, J. M.
- Affiliations
- Lahey Hospital and Medical Center (US)
- Venue
- Journal of Urology
- Published
- 2003-01
- Volume
- 169
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2105268776
- Cited by
- 423
- References
- 37
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 22 · 2023: 15 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 22 · 2018: 13 · 2017: 14 · 2016: 24 · 2015: 28 · 2014: 24 · 2013: 13 · 2012: 25
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenocortical carcinoma, adrenal tumors, Cushing's syndrome, adrenal incidentaloma, functional adrenal tumors, adrenal imaging, computed tomography, magnetic resonance imaging, mitotane, adjuvant therapy, surgical resection, prognosis
- MeSH terms
- Adrenal Cortex Neoplasms, Humans, Prognosis, Adrenocortical Carcinoma
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