Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain
Abstract
This study tested for sex differences in the effects of chronic nicotine administration and withdrawal on nicotinic acetylcholine receptor binding in brain. Rats received nicotine (0.6 mg/kg, s.c.) or saline once daily for 15 days, and were sacrificed 1 or 20 days after termination of treatment. Saturation studies of nAChR binding were performed using [3H]cytisine as the radioligand in whole brain minus cerebellum taken from animals in the chronic treatment groups and from naive rats. Male but not female rats that received chronic nicotine had higher receptor densities than corresponding control groups; up-regulation of nAChR was not seen 20 days after withdrawal. Furthermore, in groups that showed no up-regulation (controls and rats withdrawn for 20 days), nAChR densities were higher in female rats than males. The findings underscore the importance of sex differences in pharmacological responses as well as in basal neurochemical parameters.
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Preclinical studies have demonstrated that nAChR levels return to control levels after termination of nicotine exposure, but with great variability in the time course.
“Preclinical studies have demonstrated that nAChR levels return to control levels after termination of nicotine exposure, but with great variability in the time course15-17.”
From β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking (2009) · cites this paper as [17]
Cites
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Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function
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Temporal Change in Human Nicotinic Acetylcholine Receptor After Smoking Cessation: 5IA SPECT Study
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- Authors
- Koylu, E., Demirgören, S., London, E. D., & Pöǧün, S.
- Affiliations
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TR)
- National Institutes of Health (US)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 61
- Issue
- 12
- Pages
- PL185-PL190
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2088863539
- Cited by
- 104
- References
- 1
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 3 · 2013: 6 · 2012: 6
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, sex differences, chronic nicotine administration, nicotine withdrawal, receptor up-regulation, receptor density, brain, rats
- MeSH terms
- Quinolizidine Alkaloids, Alkaloids, Animals, Azocines, Brain, Drug Administration Schedule, Female, Kinetics, Male, Nicotine, Quinolizines, Radioligand Assay, Receptors, Nicotinic, Sex Characteristics, Time Factors, Up-Regulation, Rats, Sprague-Dawley, Rats
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