Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice
Open accessAbstract
Smoking appears to increase overall levels of stress, despite self-reports that men and women smoke to control symptoms of anxiety. The overall incidence of anxiety disorders is also significantly higher in women. This study examined whether behavioral sensitivity to chronic nicotine varies across sexes in mice. Male and female C57BL/6J mice were exposed chronically to nicotine in the drinking water (50, 100, or 200 microg/ml) and tested for locomotor activation and anxiety-like behavior in the elevated plus maze (EPM). Female mice were less sensitive to the locomotor activating effects of chronic nicotine. Whereas both males and females showed increases in locomotor activity at the highest (200 microg/ml) concentration of nicotine, only males showed locomotor activation at the middle (100 microg/ml) concentration. The decreased sensitivity in females could not be explained by reduced nicotine intake compared to males. In the EPM, nicotine produced an anxiogenic-like response in females, but had no effect in males. Treatment with the high (200 microg/ml) dose of nicotine reduced the amount of time spent in the open arms of the EPM in female, but not male mice. No differences in the anxiogenic-like response to chronic nicotine was observed between beta2-subunit knockout and wildtype mice, suggesting that beta2-subunit containing nicotinic receptors do not mediate the anxiogenic-like response to chronic nicotine in females. This shows that female mice have an anxiogenic-like response to chronic nicotine, but are less sensitive to nicotine's psychostimulant properties, which may be related to the increased relapse to smoking following abstinence in women.
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Chronic nicotine administration increases anxiety-like behavior in female mice but not in male mice.
“chronic administration of nicotine increased anxiety-like behavior in female, but not male, mice (Caldarone et al. 2008)”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Caldarone et al. 2008
Mice lacking the β2 nAChR subunit show no difference in anxiety-like behavior at baseline or after nicotine administration.
“no difference in anxiety-like behaviors were seen at baseline or following nicotine administration in mice lacking the β2 subunit (Caldarone et al. 2008)”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Caldarone et al. 2008
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- Authors
- Caldarone, B. J., King, S. L., & Picciotto, M. R.
- Affiliations
- Yale University (US)
- Corresponding author
- Picciotto, Marina R.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 439
- Issue
- 2
- Pages
- 187-191
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC2491450
- OpenAlex
- W2078045472
- Cited by
- 95
- References
- 47
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 10 · 2015: 12 · 2014: 1 · 2013: 5 · 2012: 6
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P50AA015632, AA15632)
- National Institute on Drug Abuse (DA14241, K02DA000436, DA 10455, R01DA014241, R29DA010455, R01DA010455, DA 00436, R37DA014241)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sex differences, chronic nicotine exposure, anxiety-like behavior, locomotor activity, elevated plus maze, smoking relapse
- MeSH terms
- Analysis of Variance, Animals, Anxiety, Behavior, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Male, Mice, Inbred C57BL, Motor Activity, Nicotine, Receptors, Nicotinic, Sex Characteristics, Mice, Knockout, Nicotinic Agonists, Maze Learning, Mice
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