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Cited by 21Diabetes, Cardiovascular Risks, and LipoproteinsHeart Rate Variability and Autonomic ControlAdipokines, Inflammation, and Metabolic Diseases

Insulin resistance syndrome and autonomically mediated physiological responses to experimentally induced mental stress in adolescent boys

Keltikangas-Järvinen, Liisa, Ravaja, Niklas, Räikkönen, Katri, Lyytinen, Heikki·1996·Metabolism
DOI 10.1016/s0026-0495(96)90033-5
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Abstract

We investigated the relationship between hemodynamic and other autonomically mediated responses to experimentally induced mental stress and the parameters of the insulin resistance syndrome (IRS) in 48 healthy adolescent boys. Mental stress was induced with mental arithmetic and the Stroop Color-Word Test. Heart rate (HR), finger blood volume (FBV), and skin conductance level (SCL) were recorded continuously during task performance. IRS parameters measured were serum insulin, high-density lipoprotein (HDL) cholesterol, serum triglyceride (TG), systolic blood pressure (SBP), subscapular skinfold (SSF), and subscapular to triceps skinfold ratio (STR). The results indicated that a high level and an increasing linear trend of HR and FBV during task performance were related, independently of each other and of body mass index (BMI), to a high insulin concentration. An increasing linear trend of HR during mental stress was also related to high SSFs independently of MI. In addition, a high SCL during task performance was associated with high TG levels, SSFs, and STRs. It is discussed whether stress-induced sympathetic overactivity might contribute to the development of the IRS.

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Crossref · 10.1016/s0026-0495(96)90033-5

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  • Chronic high levels of insulin downregulate HPA axis responses and increase basal sympathetic tone.

    “chronic high levels of insulin have been shown to downregulate HPA axis responses and increase basal sympathetic tone”

    From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Keltikangas-Jarvinen et al., 1996

  • High levels of repeated stress result in sympathetic overactivity, and stress-related increases in autonomic responses are related to insulin levels and insulin resistance in adolescents and adults.

    “High levels of repeated stress also result in sympathetic overactivity, and stress-related increases in autonomic responses are related to insulin levels and insulin resistance in adolescents and adults”

    From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Keltikangas-Jarvinen et al., 1996

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Authors
Keltikangas-Järvinen, L., Ravaja, N., Räikkönen, K., & Lyytinen, H.
Affiliations
University of Helsinki (FI)
Corresponding author
Ravaja, Niklas
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
1996-05
Volume
45
Issue
5
Pages
614-621
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/s0026-0495(96)90033-5
OpenAlex
W1984294857
Cited by
21
References
72
Citations by year
2024: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
metabolic syndrome, psychological stress, autonomic nervous system, heart rate, skin conductance, sympathetic hyperactivity, adolescent boys, serum insulin, triglycerides, skinfold thickness, body mass index, Stroop task, mental arithmetic
MeSH terms
Adolescent, Anthropometry, Autonomic Nervous System, Female, Humans, Insulin Resistance, Male, Prospective Studies, Stress, Psychological, Cohort Studies

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