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Cited by 136Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Acute noradrenergic activation induces insulin resistance in human skeletal muscle

Lembo, G., Capaldo, B., Rendina, V., Iaccarino, G., Napoli, R., Guida, R., Trimarco, B., Sacca, L.·1994·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1994.266.2.e242
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Abstract

We assessed in normal subjects the effects of an acute increase in forearm norepinephrine (NE) release, evoked by -20 mmHg lower body negative pressure (LBNP), on insulin-mediated muscle glucose uptake. Seven normal subjects underwent the following two insulin euglycemic clamps in random sequence: one during application of LBNP and the other without LBNP (control study). In the control study, hyperinsulinemia (approximately 60 microU/ml) produced a significant increment in forearm NE release, measured by using the forearm perfusion technique combined with infusion of tritiated NE (from 4.91 +/- 1 to 7.94 +/- 1.33 ng.l-1.min-1; P < 0.05). Forearm glucose uptake rose from 0.97 +/- 0.13 to 5.2 +/- 0.2 mg.l-1.min-1 in response to insulin infusion. When the insulin clamp was performed during LBNP, forearm NE release rose to significantly higher values than those of the control study (from 4.33 +/- 0.52 to 12.7 +/- 1.46 ng.l-1.min-1; P < 0.01 vs. control). Under these conditions, the stimulatory effect of insulin on forearm glucose uptake was markedly reduced (from 0.78 +/- 0.10 to 3.2 +/- 0.7 mg.l-1.min-1; P < 0.02 vs. control). Forearm blood flow and plasma epinephrine and free fatty acid concentrations were comparable in the two study sessions. These data demonstrate that an acute activation of endogenous NE release antagonizes insulin-mediated glucose uptake in forearm skeletal muscle, probably accounted for by a direct metabolic effect of NE.

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Crossref · 10.1152/ajpendo.1994.266.2.e242

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  • Reflex sympathetic vasoconstriction in the forearm of normal subjects decreases glucose uptake during hyperinsulinemia.

    “Shortly thereafter, two key studies demonstrated that reflex sympathetic vasoconstriction in the forearm of normal subjects decreased glucose uptake during hyperinsulinemia85,86.”

    From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [86]

  • Reflex sympathetic vasoconstriction in the forearm of normal subjects decreases glucose uptake during hyperinsulinemia.

    “Shortly thereafter, two key studies demonstrated that reflex sympathetic vasoconstriction in the forearm of normal subjects decreased glucose uptake during hyperinsulinemia85,86.”

    From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [85]

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Authors
Lembo, G., Capaldo, B., Rendina, V., Iaccarino, G., Napoli, R., Guida, R., Trimarco, B., & Sacca, L.
Affiliations
  • Federico II University Hospital (IT)
  • Department of Internal Medicine, School of Medicine, Federico IIUniversity, Naples, Italy.
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1994-02-01
Volume
266
Issue
2
Pages
E242-E247
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1994.266.2.e242
OpenAlex
W2399839525
Cited by
136
References
30
Citations by year
2026: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 7
FWCI
3.14
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
norepinephrine, insulin resistance, skeletal muscle glucose uptake, lower body negative pressure, noradrenaline release, insulin signaling, hyperinsulinemic-euglycemic clamp, forearm blood flow, epinephrine, free fatty acids
MeSH terms
Adult, Forearm, Glucose, Humans, Insulin, Insulin Resistance, Lower Body Negative Pressure, Male, Muscles, Norepinephrine, Reference Values, Regional Blood Flow, Time Factors

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