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A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Abstract
The subunit composition and pharmacological regulation of rat neuronal nicotinic cholinergic receptors were assessed. Specific immunoprecipitation was determined in solubilized rat brain homogenates using [3H]cytisine, a high affinity agonist at nicotinic receptors, in conjunction with polyclonal antisera generated against nonhomologous domains of the various subunits comprising this receptor class. In all brain regions tested, only antisera generated against the alpha 4 and beta 2 subunits were able to immunoprecipitate specifically receptors labeled by [3H]cytisine. Thus, these sera were further characterized in order to validate and optimize their use in the immunoprecipitation protocol. Preincubation of solubilized receptors from rat forebrain with antisera generated against the alpha 2, alpha 3, alpha 5, beta 3, or beta 4 subunits did not decrease the amount of precipitable alpha 4 or beta 2 subunit. On the other hand, when either anti-alpha 4 or anti-beta 2 serum was used to immunoprecipitate solubilized receptors from rat forebrain, the supernatants contained little if any remaining receptors that could be specifically precipitated by either antibody. Because these antisera do not cross-react, the data indicate that alpha 4 and beta 2 subunits are associated with each other in at least one neuronal nicotinic receptor subtype that has high affinity for agonists. Moreover, these results imply that all alpha 4 subunits that are labeled by [3H]cystisine are coupled to beta 2 subunits. We also present evidence that the alpha 4/beta 2 subtype characterized in this report is significantly increased in the cortex of rats chronically treated with nicotine.
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“Importantly, nicotine induced increases in nAChR, termed “upregulation”, are conferred by a specific microdomain that is in the β2-subunit 34 and thus this upregulation is confined to nAChR that contain the β2-subunit4, 19, 31, 35-38.”
From β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking (2009) · cites this paper as [19]
In the citing paper
“Immunoprecipitation with subunit-selective antibodies and studies in genetic knockout models demonstrate that chronic administration of nicotine increases predominantly the ␣42 subtype of nAChRs in rodent brain (Flores et al., 1992;Mao et al., 2008;Moretti et al., 2010;Marks et al., 2011)”
From Chronic Sazetidine-A at Behaviorally Active Doses Does Not Increase Nicotinic Cholinergic Receptors in Rodent Brain (2012) · cites this paper as Flores et al., 1992
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Items 501–600 of 880
Robinson, S. F. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02281-3 · Cited by 28
Li, S., Wu, M., Wang, X., Yuan, L., Yang, D. U., & Qi, J. (2011) · Synapse · doi:10.1002/syn.20951 · Cited by 30
Quantification of α4β2* nicotinic receptors in the rat brain with microPET® and 2-[18F]F-A-85380
Vaupel, D. B., Stein, E. A., & Mukhin, A. G. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.036 · Cited by 29
Shioda, S., Nakajo, S., Hirabayashi, T., Nakayama, H., Nakaya, K., Matsuda, K., & Nakai, Y. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00122-8 · Cited by 29
Elliott, R. L., Ryther, K. B., Anderson, D. J., Piattoni-Kaplan, M., Kuntzweiler, T. A., Donnelly‐Roberts, D. L., Arnerić, S. P., & Holladay, M. W. (1997) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(97)10080-4 · Cited by 29
Huang, Z.-G., Wang, X., Evans, C. R., Gold, A. B., Bouairi, E., & Mendelowitz, D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00500.2004 · Cited by 29
Perry, E. K., COURT, J. A., Johnson, M., Smith, C. J., James, V. A., Cheng, A. V., Kerwin, J. M., Morris, C. M., Piggott, M. A., Edwardson, J. A., et al. (1993) · Hippocampus · doi:10.1002/hipo.450030306 · Cited by 29
Arora, K., Alfulaij, N., Higa, J. K., Panee, J., & Nichols, R. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.453746 · Cited by 29
Dávila‐García, M. I., Houghtling, R. A., Qasba, S. S., & Kellar, K. J. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00344-1 · Cited by 28
Marszalec, W., Yeh, J. Z., & Narahashi, T. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.017 · Cited by 28
Liu, X. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000874 · Cited by 31
Pittaras, E., Faure, A., Leray, X., Moraitopoulou, E., Cressant, A., Rabat, A., Meunier, C. N. J., Fossier, P., & Granon, S. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00171 · Cited by 29
Café-Mendes, C. C., Garay-Malpartida, M., Malta, M. B., Lima, L. D. S., Scavone, C., Ferreira, Z. S., Markus, R. P., & Marcourakis, T. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.056 · Cited by 30
Slotkin, T. A., Lassiter, T. L., Ryde, I. T., Wrench, N., Levin, E. D., & Seidler, F. J. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800459 · Cited by 28
GTS-21, A Mixed Nicotinic Receptor Agonist/Antagonist, Does Not Affect The Nicotine Cue
van Haaren, F., Anderson, K. G., Haworth, S. C., & Kem, W. R. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00054-4 · Cited by 28
Shafaee, N., Houng, M., Truong, A., Viseshakul, N., Figl, A., Sandhu, S. K., Forsayeth, J., Dwoskin, L. P., Crooks, P. A., & Cohen, B. N. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702900 · Cited by 28
Subunit and region-specific decreases in nicotinic acetylcholine receptor mRNA in the aged rat brain
Ferrari, R., Pedrazzi, P., Algeri, S., Agnati, L. F., & Zoli, M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00015-9 · Cited by 29
Greenwood, P. M., Sundararajan, R., Lin, M., Kumar, R., Fryxell, K. J., & Parasuraman, R. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21164 · Cited by 29
Koulousakis, P., Andrade, P., Visser-Vandewalle, V. E. R. M., & Sesia, T. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180133 · Cited by 27
Wilkerson, J. L., Deba, F., Crowley, M. L., Hamouda, A. K., & McMahon, L. R. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108008 · Cited by 29
Browne, C. J., Sharma, N., Waters, K. A., & Machaalani, R. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.10.005 · Cited by 27
Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation
Mohamed, T. S., Jayakar, S. S., & Hamouda, A. K. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00071 · Cited by 27
The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity α4β2 nAChRs
Kim, H., Flanagin, B. A., Qin, C., Macdonald, R. L., & Stitzel, J. A. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00167-9 · Cited by 27
Kozikowski, A. P., Chellappan, S. K., Xiao, Y., Bajjuri, K. M., Yuan, H., Kellar, K. J., & Petukhov, P. A. (2007) · ChemMedChem · doi:10.1002/cmdc.200700073 · Cited by 28
Vincler, M. A., & Eisenach, J. C. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.10.011 · Cited by 27
Josiah, D. T., & Vincler, M. A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0481-5 · Cited by 27
Curzon, P., Brioni, J. D., & Decker, M. W. (1996) · Brain Research · doi:10.1016/0006-8993(95)01536-1 · Cited by 27
Multiple Cholinergic Signaling Pathways in Pituitary Gonadotrophs
Zemkova, H. W., Kučka, M., Bjelobaba, I. M., Tomić, M., & Stojilković, S. S. (2012) · Endocrinology · doi:10.1210/en.2012-1554 · Cited by 26
Levin, E. D., Tizabi, Y., Rezvani, A. H., Caldwell, D. P., Petro, A. E., & Getachew, B. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.104 · Cited by 26
Nicotinic receptor modulation of neurotransmitter release in the cerebellum
Filippi, G. D., Baldwinson, T., & Sher, E. (2005) · Progress in brain research · doi:10.1016/s0079-6123(04)48024-8 · Cited by 25
Yu, W., Guan, Z.-Z., & Nordberg, A. K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.002 · Cited by 26
Nunes‐Freitas, A. L., Ribeiro‐Carvalho, A., Lima, C. S., Dutra-Tavares, A. C., Manhães, A. C., Lisboa, P. C., OLIVEIRA, E. B. D., de Moura, E. G., Filgueiras, C. C., & Abreu‐Villaça, Y. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr147 · Cited by 26
Determinants of agonist binding affinity on neuronal nicotinic receptor beta subunits.
Parker, M. J., Harvey, S. C., & Luetje, C. W. (2001) · PubMed · Cited by 26
Immunocytochemical localization of nicotinic acetylcholine receptor in the rat cerebellar cortex
Nakayama, H., Shioda, S., Nakajo, S., Ueno, S., Nakashima, T., & Nakai, Y. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00100-4 · Cited by 26
Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly
Gahring, L. C., Days, E., Kaasch, T., de Mendoza, M. G., Owen, L. A., Persiyanov, K., & Rogers, S. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.007 · Cited by 26
Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging
Kant, R., Constantinescu, C. C., Parekh, P. K., Pandey, S. K., Pan, M., Easwaramoorthy, B., & Mukherjee, J. (2011) · EJNMMI Research · doi:10.1186/2191-219x-1-6 · Cited by 26
Hall, B. J., Pearson, L. S., & Buccafusco, J. J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.011 · Cited by 26
Treating Schizophrenia: Novel Targets for the Cholinergic System
Money, T., Scarr, E., Udawela, M., Gibbons, A. S., Jeon, W. J., Seo, M. S., & Dean, B. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012062 · Cited by 24
Discovery of novel α7 nicotinic receptor antagonists
Peng, Y., Zhang, Q., Snyder, G. L., Zhu, H., Yao, W., Tomesch, J., Papke, R. L., O'Callaghan, J. P., Welsh, W. J., & Wennogle, L. P. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.06.103 · Cited by 25
RIC-3 expression and splicing regulate nAChR functional expression
Ben‐David, Y., Mizrachi, T., Kagan, S. A., Krisher, T., Cohen, E., Brenner, T., & Treinin, M. (2016) · Molecular Brain · doi:10.1186/s13041-016-0231-5 · Cited by 25
Johnston, R., Doma, K., & Crowe, M. (2017) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12443 · Cited by 28
Zhang, X., Tian, J., Svensson, A., Gong, Z., Meyerson, B. J., & Nordberg, A. K. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200030 · Cited by 25
Tani, Y., Saito, K., Tsuneyoshi, A., Imoto, M., & Ohno, T. (1997) · Psychopharmacology · doi:10.1007/s002130050184 · Cited by 25
Marks, M. J., Stitzel, J. A., Grady, S. R., Picciotto, M. R., Changeux, J., & Collins, A. C. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00115-5 · Cited by 24
Damaj, M. I., & Martin, B. R. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00834-9 · Cited by 25
Grinevich, V. P., Crooks, P. A., Sumithran, S. P., Haubner, A. J., Ayers, J. T., & Dwoskin, L. P. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051789 · Cited by 25
Vasopressin and developmental onset of flank marking behavior in golden hamsters
Ferris, C. F., Delville, Y., Brewer, J. A., Mansour, K., Yules, B., & Melloni, R. H. (1996) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199606)30:2 · Cited by 29
Sihver, W., Fasth, K., Horti, A. G., Koren, A. O., Bergström, M., Lu, L., Hagberg, G. E., Lundqvist, H., Dannals, R. F., London, E. D., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731264.x · Cited by 25
Exogenous Aβ1-42 monomers improve synaptic and cognitive function in Alzheimer's disease model mice
Duan, Y., Lv, J., Zhang, Z., Chen, Z., Wu, H., Chen, J., Chen, Z., Yang, J., Wang, D., Liu, Y., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109002 · Cited by 24
Kroker, K. S., Moreth, J., Kußmaul, L., Rast, G. F., & Rosenbrock, H. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.04.006 · Cited by 24
Liu, X., Koren, A. O., Yee, S. K., Pechnick, R. N., Poland, R. E., & London, E. D. (2003) · Neuroreport · doi:10.1097/00001756-200308060-00020 · Cited by 24
Nicotinic Receptor Inhibition by Tetraponera Ant Alkaloids
Kem, W. R., Wildeboer, K. M., LeFrancois, S., Raja, M., Marszalec, W., & Braekman, J. C. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000023628.65936.a7 · Cited by 24
Tobacco addiction: A biochemical model of nicotine dependence
Ortells, M. O., & Barrantes, G. E. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.11.004 · Cited by 26
DeDominicis, K. E., Sahibzada, N., Olson, T. T., Xiao, Y., Wolfe, B. B., Kellar, K. J., & Yasuda, R. P. (2017) · Molecular Pharmacology · doi:10.1124/mol.116.106880 · Cited by 24
Development of Alzheimer's disease imaging agents for clinical studies
Ryu, E. K. (2007) · Frontiers in bioscience · doi:10.2741/2719 · Cited by 23
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues
Xu, R., Dwoskin, L. P., Grinevich, V. P., Deaciuc, A. G., & Crooks, P. A. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00193-7 · Cited by 24
Gündisch, D., Koren, A. O., Horti, A. G., Pavlova, O. A., Kimes, A. S., Mukhin, A. G., & London, E. D. (2004) · Synapse · doi:10.1002/syn.20096 · Cited by 23
Madhok, T. C., Matta, S. G., & Sharp, B. M. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00073-2 · Cited by 24
Hussmann, G. P., DeDominicis, K. E., Turner, J. R., Yasuda, R. P., Klehm, J., Forcelli, P. A., Xiao, Y., Richardson, J. R., Sahibzada, N., Wolfe, B. B., et al. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12653 · Cited by 23
Guo, X., & Wecker, L. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01027.x · Cited by 23
Wecker, L., Pollock, V. V., Pacheco, M. A., & Pastoor, T. E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.005 · Cited by 23
Saika, F., Kiguchi, N., Kobayashi, Y., & Kishioka, S. (2015) · Acta Physiologica · doi:10.1111/apha.12437 · Cited by 27
L-DOPA Treatment Modulates Nicotinic Receptors in Monkey Striatum
Quik, M., Bordia, T., Okihara, M., Fan, H., Marks, M. J., McIntosh, J. M., & Whiteaker, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.619 · Cited by 27
López‐Hernández, G. Y., Thinschmidt, J. S., Zheng, G., Zhang, Z., Crooks, P. A., Dwoskin, L. P., & Papke, R. L. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056176 · Cited by 23
Ellis, J. R., Nathan, P. J., Villemagne, V. L., Mulligan, R. S., Saunder, T., Young, K., Smith, C. S., Welch, J., Woodward, M., Wesnes, K. A., et al. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1347-9 · Cited by 23
Xu, R., Dwoskin, L. P., Grinevich, V. P., Sumithran, S. P., & Crooks, P. A. (2002) · Drug Development Research · doi:10.1002/ddr.10049 · Cited by 23
ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity
Brioni, J. D., Kim, D. J. B., Brodie, M. S., Decker, M. W., & Arnerić, S. P. (1995) · Psychopharmacology · doi:10.1007/bf02245851 · Cited by 23
Lin, N., Li, Y., He, Y., Holladay, M. W., Kuntzweiler, T. A., Anderson, D. J., Campbell, J. E., & Arnerić, S. P. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00030-0 · Cited by 23
Lobron, C., Wevers, A., Dämgen, K., Jeske, A., Rontal, D., Birtsch, C., Heinemann, S., Reinhardt, S., Maelicke, A., & Schröder, H. C. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00279-n · Cited by 23
Ostermann, C.-H., Grünwald, J., Wevers, A., Lorke, D. E., Reinhardt, S., Maelicke, A., & Schröder, H. C. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11598-q · Cited by 23
Escubedo, E., Camarasa, J., Chipana, C., Garcia-Ratés, S., & Pubill, D. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)88006-9 · Cited by 23
Rezvani, A. H., Tizabi, Y., Getachew, B., Hauser, S. R., Caldwell, D. P., Hunter, C., & Levin, E. D. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.018 · Cited by 22
Turner, J. R., Ortinski, P. I., Sherrard, R. M., & Kellar, K. J. (2011) · The Cerebellum · doi:10.1007/s12311-011-0285-y · Cited by 22
Nishizaki, T., Nomura, T., Matsuyama, S., Kondoh, T., Fujimoto, E., & Yoshii, M. (2001) · Psychogeriatrics · doi:10.1111/j.1479-8301.2001.tb00050.x · Cited by 22
Sorger, D., Becker, G., Patt, M., Schildan, A., Großmann, U., Schliebs, R., Seese, A., Kendziorra, K., Kluge, M., Brust, P., et al. (2007) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2006.12.008 · Cited by 22
Cholinergic receptor subtypes in the olfactory bulbectomy model of depression
Slotkin, T. A., & Seidler, F. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.09.005 · Cited by 22
Gahring, L. C., & Rogers, S. W. (2008) · Hippocampus · doi:10.1002/hipo.20430 · Cited by 21
Characterization of Human α4β2 Neuronal Nicotinic Receptors Stably Expressed in SH-EP1 Cells
Pacheco, M. A., Pastoor, T. E., Lukas, R. J., & Wecker, L. (2001) · Neurochemical Research · doi:10.1023/a:1010995521851 · Cited by 22
Saldanha, C. J., Tuerk, M. J., Kim, Y., Fernandes, A. O., Arnold, A. P., & Schlinger, B. A. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000807)423:4 · Cited by 245
Britto, L. R. G., Rogers, S. W., Hamassaki‐Britto, D. E., & Duvoisin, R. M. (1994) · Visual Neuroscience · doi:10.1017/s0952523800002479 · Cited by 22
Leonard, S. S. (2003) · Drug Development Research · doi:10.1002/ddr.10292 · Cited by 23
Raines, D. E., Claycomb, R., & Forman, S. A. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200209000-00015 · Cited by 22
Chronic nicotine-induced improvement of spatial working memory and D2 dopamine effects in rats
Levin, E. D., Christopher, N. C., Briggs, S. J., & Auman, J. T. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(19960901)39:1 · Cited by 19
The Distribution of Neuronal Nicotinic Acetylcholine Receptors
Sargent, P. B. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_7 · Cited by 22
Hoegberg, B. G., Lomazzo, E., Lee, N. H., & Perry, D. C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.015 · Cited by 17
Kitabatake, T., Moaddel, R., Cole, R., Gandhari, M., Frazier, C., Hartenstein, J., Rosenberg, A., Bernier, M., & Wainer, I. W. (2008) · Analytical Chemistry · doi:10.1021/ac8016407 · Cited by 21
Nicotine and nicotinic system in hypoglutamatergic models of schizophrenia
Tizabi, Y. (2007) · Neurotoxicity research · doi:10.1007/bf03033907 · Cited by 8
Salas, R., Main, A., Gangitano, D. A., Zimmerman, G., Ben‐Ari, S., Soreq, H., & Biasi, M. D. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048454 · Cited by 21
Neuronal nicotinic acetylcholine receptor ligands as potential analgesics
Bunnelle, W. H., & Decker, M. W. (2003) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.13.7.1003 · Cited by 21
Zwart, R., Abraham, D., Oortgiesen, M., & Vijverberg, H. P. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)90493-6 · Cited by 21
Didier, M., Bix, G. J., Berman, S. A., & Bursztajn, S. (1995) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(95)00062-3 · Cited by 21
Phenyl pyrrolidine analogues as potent nicotinic acetylcholine receptor (nAChR) ligands
Elliott, R. L., Ryther, K. B., Anderson, D. J., Raszkiewicz, J. L., Campbell, J. E., Sullivan, J. P., & Garvey, D. S. (1995) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/0960-894x(95)00154-l · Cited by 21
Expression of two neuronal nicotinic receptor subunits in innervated and denervated adult rat muscle
Sala, C., Kimura, I., Santoro, G., Kimura, M., & Fumagalli, G. F. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12923-2 · Cited by 21
Modulation of Neuronal Nicotinic Acetylcholine Receptors by Mercury
Mirzoian, A., & Luetje, C. W. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035154 · Cited by 21
Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity
Wilking, J. A., Hesterberg, K. G., Crouch, E. L., Homanics, G. E., & Stitzel, J. A. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283369347 · Cited by 20
Dehkordi, O., Kc, P., Balan, K., & Haxhiu, M. (2006) · Autonomic Neuroscience: Basic & Clinical · doi:10.1016/j.autneu.2006.02.023 · Cited by 18
Traditional Medicine for Memory Enhancement
Howes, M. R., & Houghton, P. J. (2008) · Springer eBooks · doi:10.1007/978-3-540-79116-4_15 · Cited by 22
Li, J., Flotildes, K., Li, M., & Cohen, B. N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01578.x · Cited by 19
Watanabe, H., Zoli, M., & Changeux, J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00235.x · Cited by 20
Orb, S., Wieacker, J., Labarca, C. G., Fonck, C., Lester, H. A., & Schwarz, J. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00012.2004 · Cited by 20
Metadata
- Authors
- Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J.
- Affiliations
- Georgetown University Medical Center (US)
- University of Colorado Denver (US)
- Georgetown University (US)
- ORCID
- Kellar, K J
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 41
- Issue
- 1
- Pages
- 31-37
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2116249462
- Cited by
- 880
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 18 · 2015: 25 · 2014: 25 · 2013: 22 · 2012: 21
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Institutes of Health (5r01ag009884-05, 5r01da006486-10, 5r01ns011549-24)
- National Institute on Aging (AG 09884)
- National Institute on Drug Abuse (DA-06486)
- National Institute of Neurological Disorders and Stroke (NS11549)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, receptor subunit composition, chronic nicotine treatment, receptor up-regulation, rat cortex, forebrain, neuronal nicotinic receptors
- MeSH terms
- Quinolizidine Alkaloids, Alkaloids, Animals, Antibodies, Azocines, Brain, Kinetics, Male, Nicotine, Precipitin Tests, Quinolizines, Rats, Inbred Strains, Receptors, Nicotinic, Time Factors, Tritium, Up-Regulation, Macromolecular Substances, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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