Cited by 880Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

The DOI matches its Crossref record.

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

Flores, C M, Rogers, S W, Pabreza, L A, Wolfe, B B, Kellar, K J·1992·Molecular Pharmacology

DOI 10.1016/s0026-895x(25)08832-7

Open this paper in CoChat — free account

Abstract

The subunit composition and pharmacological regulation of rat neuronal nicotinic cholinergic receptors were assessed. Specific immunoprecipitation was determined in solubilized rat brain homogenates using [3H]cytisine, a high affinity agonist at nicotinic receptors, in conjunction with polyclonal antisera generated against nonhomologous domains of the various subunits comprising this receptor class. In all brain regions tested, only antisera generated against the alpha 4 and beta 2 subunits were able to immunoprecipitate specifically receptors labeled by [3H]cytisine. Thus, these sera were further characterized in order to validate and optimize their use in the immunoprecipitation protocol. Preincubation of solubilized receptors from rat forebrain with antisera generated against the alpha 2, alpha 3, alpha 5, beta 3, or beta 4 subunits did not decrease the amount of precipitable alpha 4 or beta 2 subunit. On the other hand, when either anti-alpha 4 or anti-beta 2 serum was used to immunoprecipitate solubilized receptors from rat forebrain, the supernatants contained little if any remaining receptors that could be specifically precipitated by either antibody. Because these antisera do not cross-react, the data indicate that alpha 4 and beta 2 subunits are associated with each other in at least one neuronal nicotinic receptor subtype that has high affinity for agonists. Moreover, these results imply that all alpha 4 subunits that are labeled by [3H]cystisine are coupled to beta 2 subunits. We also present evidence that the alpha 4/beta 2 subtype characterized in this report is significantly increased in the cortex of rats chronically treated with nicotine.

Integrity signals

Registry

Crossref · 10.1016/s0026-895x(25)08832-7

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–300 of 880

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence
Hancock, D. B., Reginsson, G. W., Gaddis, N. C., Chen, X., Saccone, N. L., Lutz, S. M., Qaiser, B., Sherva, R., Steinberg, S., Zink, F., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.149 · Cited by 85
Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation
Grillner, P., & Svensson, T. H. (2000) · Synapse · doi:10.1002/1098-2396(200010)38:1 · Cited by 75
Nicotinic Cholinergic Receptors in the Rat Cerebellum: Multiple Heteromeric Subtypes
Turner, J. R., & Kellar, K. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2112-05.2005 · Cited by 89
Nicotine-induced norepinephrine release in the rat amygdala and hippocampus is mediated through brainstem nicotinic cholinergic receptors.
Fu, Y.-T., Matta, S. G., James, T. J., & Sharp, B. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37341-0 · Cited by 92
Development of ligands for in vivo imaging of cerebral nicotinic receptors
Sihver, W., Nordberg, A. K., Långström, B., Mukhin, A. G., Koren, A. O., Kimes, A. S., & London, E. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00209-6 · Cited by 86
Formation of Oligomers Containing the β3 and β4 Subunits of the Rat Nicotinic Receptor
Forsayeth, J., & Kobrin, E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01531.1997 · Cited by 85
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype
Walsh, H., Govind, A. P., Mastro, R., Hoda, J. C., Bertrand, D., Vallejo, Y., & Green, W. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m703432200 · Cited by 87
Neonatal Exposure to Low Doses of Diazinon: Long-Term Effects on Neural Cell Development and Acetylcholine Systems
Slotkin, T. A., Bodwell, B. E., Levin, E. D., & Seidler, F. J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.11005 · Cited by 87
Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation
Abdulla, F. A., Gray, J. A., Sinden, J. D., Bradbury, E. J., Calaminici, M., Lippiello, P. M., & Wonnacott, S. (1996) · Psychopharmacology · doi:10.1007/bf02247437 · Cited by 85
Neuronal and astrocyte expression of nicotinic receptor subunit β4 in the adult mouse brain
Gahring, L. C., Persiyanov, K., & Rogers, S. W. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10942 · Cited by 86
Subunit Composition of Nicotinic Receptors in Monkey Striatum: Effect of Treatments with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine or l-DOPA
Quik, M., Vailati, S., Bordia, T., Kulak, J. M., Fan, H., McIntosh, J. M., Clementi, F., & Gotti, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.006015 · Cited by 86
Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells.
Stauderman, K. A., Mahaffy, L. S., Akong, M., Veliçelebi, G., Chavez-Noriega, L. E., Crona, J. H., Johnson, E. C., Elliott, K. J., Gillespie, A., Reid, R. T., et al. (1998) · PubMed · doi:10.7270/q28g8j7q · Cited by 86
Nicotinic Acetylcholine Receptors in Alzheimer's Disease
Wevers, A., & Schröder, H. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-14-503 · Cited by 84
Receptor-Mediated Tobacco Toxicity
Arredondo, J., Chernyavsky, A. I., Marubio, L. M., Beaudet, A. L., Jolkovsky, D. L., Pinkerton, K. E., & Grando, S. A. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62281-x · Cited by 84
Mouse strain‐specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus
Gahring, L. C., Persiyanov, K., Dunn, D. M., Weiss, R. B., Meyer, E. L., & Rogers, S. W. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10943 · Cited by 84
Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors
Decker, M. W., Anderson, D. J., Brioni, J. D., Donnelly‐Roberts, D. L., Kang, C. H., O'Neill, A. B., Piattoni-Kaplan, M., Swanson, S. T., & Sullivan, J. P. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00191-m · Cited by 84
Nicotine-evoked [3H]5-hydroxytryptamine release from rat striatal synaptosomes
Reuben, M., & Clarke, P. B. S. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00147-1 · Cited by 84
The Molecular Biology of Neuronal Nicotinic Acetylcholine Receptors
Boyd, R. T. (1997) · Critical Reviews in Toxicology · doi:10.3109/10408449709089897 · Cited by 84
Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long‐term but not short‐term nicotine treatment
Nguyen, H. N., Rasmussen, B. A., & Perry, D. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02482.x · Cited by 83
Presynaptic α4β2 Nicotinic Acetylcholine Receptors Increase Glutamate Release and Serotonin Neuron Excitability in the Dorsal Raphe Nucleus
Garduño, J., Galindo-Charles, L., Jiménez-Rodríguez, J., Galarraga, E., Tapia, D., Mihailescu, S., & Hernandez-Lopez, S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0941-12.2012 · Cited by 83
Nicotine gates long‐term potentiation in the hippocampal CA1 region via the activation of α2* nicotinic ACh receptors
Nakauchi, S., Brennan, R. J., Boulter, J., & Sumikawa, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05513.x · Cited by 84
Neuroprotective and Memory-Related Actions of Novel Alpha-7 Nicotinic Agents with Different Mixed Agonist/Antagonist Properties
Meyer, E. M., Tay, E. T., Zoltewicz, J. A., Meyers, C., King, M. A., Papke, R. L., & de Fiebre, C. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37338-0 · Cited by 83
Subunit-Dependent Modulation of Neuronal Nicotinic Receptors by Zinc
Hsiao, B., Dweck, D., & Luetje, C. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01848.2001 · Cited by 83
Graphical analysis of 2‐[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain
Chefer, S. I., London, E. D., Koren, A. O., Pavlova, O. A., Kurian, V., Kimes, A. S., Horti, A. G., & Mukhin, A. G. (2003) · Synapse · doi:10.1002/syn.10180 · Cited by 82
Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat
Bitner, R. S., Nikkel, A. L., Curzon, P., Donnelly‐Roberts, D. L., Puttfarcken, P. S., Namovic, M. T., Jacobs, I. C., Meyer, M. D., & Decker, M. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02442-2 · Cited by 82
Localization of nicotinic cholinergic receptors in rat brain: Autoradiographic studies with [3H]cytisine
Happe, H. K., Peters, J. L., Bergman, D. A., & Murrin, L. C. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90484-7 · Cited by 82
Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline
Turner, J. R., Castellano, L. M., & Blendy, J. A. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq206 · Cited by 78
Nicotine and endogenous opioids: neurochemical and pharmacological evidence
Hadjiconstantinou, M., & Neff, N. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.010 · Cited by 81
Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia
Mao, D., Yasuda, R. P., Fan, H., Wolfe, B. B., & Kellar, K. J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027458 · Cited by 81
Self-citation
Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment
Marks, M. J., Rowell, P. P., Cao, J., Grady, S. R., McCallum, S. E., & Collins, A. C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.02.009 · Cited by 81
Regulation of α4β2 Nicotinic Receptor Desensitization by Calcium and Protein Kinase C
Fenster, C. P., Beckman, M. L., Parker, J. C., Sheffield, E. B., Whitworth, T. L., Quick, M. W., & Lester, R. A. J. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12167-0 · Cited by 81
Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
Portugal, G. S., Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.003 · Cited by 79
An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine
Sallette, J., Bohler, S., Benoit, P., Soudant, M., Pons, S., Le Novère, N., Changeux, J.-P., & Corringer, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308260200 · Cited by 80
Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain
Koylu, E., Demirgören, S., London, E. D., & Pöǧün, S. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00665-6 · Cited by 104
Cortical Hypoexcitability in Chronic Smokers? A Transcranial Magnetic Stimulation Study
Lang, N., Hasan, A., Sueske, E., Paulus, W., & Nitsche, M. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301645 · Cited by 80
Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray
Kroes, R. A., Burgdorf, J. S., Otto, N. J., Panksepp, J., & Moskal, J. R. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.022 · Cited by 81
Neurological disorders caused by inherited ion-channel mutations
Kullmann, D. M., & Hanna, M. G. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00071-6 · Cited by 80
Chapter 7: Nicotinic receptors in mammalian brain: localization and relation to cholinergic innervation
Clarke, P. B. S. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62383-3 · Cited by 78
Blockade of nicotinic receptor‐mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administeredin vitro
El-Bizri, H., & Clarke, P. B. S. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14749.x · Cited by 79
Two Pharmacologically Distinct Components of Nicotinic Receptor-Mediated Rubidium Efflux in Mouse Brain Require the β2 Subunit
Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J.-P., & Collins, A. C. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38240-0 · Cited by 79
Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the α7, α4 and β2 subunits in response to nanomolar concentrations of the β-amyloid peptide1–42
Xiu, J., Nordberg, A. K., Zhang, J., & Guan, Z.-Z. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.04.023 · Cited by 82
ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties
Sullivan, J. P., Donnelly‐Roberts, D. L., Briggs, C. A., Anderson, D. J., Gopalakrishnan, M., Xue, I. C., Piattoni-Kaplan, M., Molinari, E. J., Campbell, J. E., McKenna, D. G., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37014-4 · Cited by 79
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors
Henderson, B. J., Srinivasan, R., Nichols, W. A., Dilworth, C. N., Gutierrez, D. F., Mackey, E. D. W., McKinney, S., Drenan, R. M., Richards, C. I., & Lester, H. A. (2014) · Journal of General Physiology · doi:10.1085/jgp.201311102 · Cited by 78
Analgesic and Toxic Effects of Neonicotinoid Insecticides in Mice
Tomizawa, M., Cowan, A., & Casida, J. E. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9292 · Cited by 78
Up-regulation of Cell-surface α4β2 Neuronal Nicotinic Receptors by Lower Temperature and Expression of Chimeric Subunits
Cooper, S. T., Harkness, P. C., Baker, E. R., & Millar, N. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27145 · Cited by 78
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A Novel, Orally Effective Antinociceptive Agent Acting via Neuronal Nicotinic Acetylcholine Receptors: II. In Vivo Characterization
Bannon, A. W., Decker, M. W., Curzon, P., Buckley, M. J., Kim, D. J. B., Radek, R. J., Lynch, J. K., Wasicak, J. T., Lin, N., Arnold, W. H., et al. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37423-3 · Cited by 78
Role of α5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice
Fowler, C. D., Tuesta, L. M., & Kenny, P. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3235-1 · Cited by 79
Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas
Matta, J. A., Gu, S., Davini, W. B., & Bredt, D. S. (2021) · Science · doi:10.1126/science.abg6539 · Cited by 75
Positive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review
Hurley, L. L., Taylor, R. E., & Tizabi, Y. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9275-6 · Cited by 83
Region-Specific Effects of Nicotine on Brain Activity: A Pharmacological MRI Study in the Drug-Naïve Rat
Gozzi, A., Schwarz, A. J., Reese, T., Bertani, S., Crestan, V., & Bifone, A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300955 · Cited by 77
Exocytic trafficking is required for nicotine-induced up-regulation of α4β2 nicotinic acetylcholine receptors
Darsow, T., Booker, T. K., Piña-Crespo, J. C., & Heinemann, S. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501157200 · Cited by 76
Effect of nicotine, lobeline, and mecamylamine on sensory gating in the rat
Curzon, P., Kim, D. J. B., & Decker, M. W. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90237-2 · Cited by 76
Long-Term Nicotine Adaptation inCaenorhabditis elegansInvolves PKC-Dependent Changes in Nicotinic Receptor Abundance
Waggoner, L. E., Dickinson, K., Poole, D. S., Tabuse, Y., Miwa, J., & Schafer, W. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08802.2000 · Cited by 76
Cytoprotective actions of 2,4‐dimethoxybenzylidene anabaseine in differentiated PC12 cells and septal cholinergic neurons
Martin, E. J., Panickar, K. S., King, M. A., Deyrup, M. D., Hunter, B. E., Wang, G., & Meyer, E. M. (1994) · Drug Development Research · doi:10.1002/ddr.430310208 · Cited by 76
Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain
Pandey, S. C., Roy, A., Xu, T., & Mittal, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00309.x · Cited by 75
Agonist-Induced Up-Regulation of α4β2 Nicotinic Acetylcholine Receptors in M10 Cells: Pharmacological and Spatial Definition
Whiteaker, P., Sharples, C. G. V., & Wonnacott, S. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13263-4 · Cited by 152
Roles of nicotinic acetylcholine receptor β subunits in function of human α4‐containing nicotinic receptors
Wu, J., Liu, Q., Yu, K., Hu, J., Kuo, Y., Segerberg, M., John, P. A. S., & Lukas, R. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.114645 · Cited by 74
Changes in Conformation and Subcellular Distribution of α4β2 Nicotinic Acetylcholine Receptors Revealed by Chronic Nicotine Treatment and Expression of Subunit Chimeras
Harkness, P. C., & Millar, N. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10172.2002 · Cited by 74
β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic α6* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines
Tumkosit, P., Kuryatov, A., Luo, J., & Lindstrom, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027326 · Cited by 73
Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells
Chavez-Noriega, L. E., Gillespie, A. J., Stauderman, K. A., Crona, J. H., Claeps, B. O., Elliott, K. J., Reid, R. T., Rao, T. S., Veliçelebi, G., Harpold, M. M., et al. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00134-9 · Cited by 73
Acetylcholine Receptors: Too Many Channels, Too Few Functions
Sivilotti, L. G., & Colquhoun, D. (1995) · Science · doi:10.1126/science.7569892 · Cited by 73
β2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
Davis, J. A., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0624-8 · Cited by 72
Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors
Hogg, R. C., & Bertrand, D. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.010 · Cited by 72
Cellular distribution of nicotinic acetylcholine receptor subunit mRNAs in the human cerebral cortex as revealed by non-isotopic in situ hybridization
Wevers, A., Jeske, A., Lobron, C., Birtsch, C., Heinemann, S., Maelicke, A., Schröder, R., & Schröder, H. C. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90286-0 · Cited by 72
Neurochemical Evidence of Heterogeneity of Presynaptic and Somatodendritic Nicotinic Acetylcholine Receptorsa
Vizi, E. S., Sershen, H. W., BALLA, A., Mike, Á., Windisch, K., Jurányi, Z., & Lajtha, Á. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17466.x · Cited by 72
Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
McCallum, S. E., Collins, A. C., Paylor, R. E., & Marks, M. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0076-6 · Cited by 71
Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research
Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.006 · Cited by 73
Functional Deactivation of the Major Neuronal Nicotinic Receptor Caused by Nicotine and a Protein Kinase C-Dependent Mechanism
Eilers, H., Schaeffer, E., Bickler, P. E., & Forsayeth, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.6.1105 · Cited by 71
Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain
Marks, M. J., McClure-Begley, T. D., Whiteaker, P., Salminen, O., Brown, R. W. B., Cooper, J., Collins, A. C., & Lindstrom, J. M. (2011) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.178236 · Cited by 70
Depressive Characteristics of FSL Rats
Tizabi, Y., Rezvani, A. H., Russell, L. T., Tyler, K. Y., & Overstreet, D. H. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00236-7 · Cited by 70
Lobeline inhibits nicotine-evoked [3H]dopamine overflow from rat striatal slices and nicotine-evoked 86Rb+ efflux from thalamic synaptosomes
Miller, D. K., Crooks, P. A., & Dwoskin, L. P. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00140-4 · Cited by 71
Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain—an in vivo microdialysis study
Tani, Y., Saito, K., Imoto, M., & Ohno, T. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00314-8 · Cited by 69
The Effect of Maternal Smoking and Drinking During Pregnancy Upon 3H‐Nicotine Receptor Brainstem Binding in Infants Dying of the Sudden Infant Death Syndrome: Initial Observations in a High Risk Population
Duncan, J., Randall, L. L., Belliveau, R., Trachtenberg, F., Randall, B., Habbe, D., Mandell, F., Welty, T. K., Iyasu, S., & Kinney, H. C. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00093.x · Cited by 75
Partial Deletion of the Nicotinic Cholinergic Receptor α4 or β2 Subunit Genes Changes the Acetylcholine Sensitivity of Receptor-Mediated 86Rb+ Efflux in Cortex and Thalamus and Alters Relative Expression of α4 and β2 Subunits
Gotti, C., Moretti, M., Meinerz, N. M., Clementi, F., Gaimarri, A., Collins, A. C., & Marks, M. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.045203 · Cited by 68
Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine
Dwoskin, L. P., Crooks, P. A., Teng, L., Green, T. A., & Bardo, M. T. (1999) · Psychopharmacology · doi:10.1007/s002130051079 · Cited by 68
Imaging of Cholinergic and Monoaminergic Neurochemical Changes in Neurodegenerative Disorders
Bohnen, N. I., & Frey, K. A. (2007) · Molecular Imaging and Biology · doi:10.1007/s11307-007-0083-6 · Cited by 67
Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain
Gao, B.-X., Hierl, M., Clarkin, K., Juan, T., Nguyen, H. Q., van der Valk, M., Deng, H. X., Guo, W., Lehto, S. G., Matson, D. J., et al. (2010) · Pain · doi:10.1016/j.pain.2010.01.007 · Cited by 67
Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual Cortex In Vivo
Hanganu, I. L., Staiger, J. F., Ben-Ari, Y., & Khazipov, R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5233-06.2007 · Cited by 67
Up-regulation of nicotinic acetylcholine receptors following chronic exposure of rats to mainstream cigarette smoke or α4β2 receptors to nicotine
Yates, S. L., Bencheri, M., Fluhler, E. N., & Lippiello, P. M. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02100-0 · Cited by 65
Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging
Levin, E. D., Timofeeva, O. A., Yang, L., Petro, A. E., Ryde, I. T., Wrench, N., Seidler, F. J., & Slotkin, T. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.007 · Cited by 66
Subtype-selective nicotinic agonists enhance olfactory working memory in normal rats: A novel use of the odour span task
Rushforth, S. L., Allison, C., Wonnacott, S., & Shoaib, M. C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.022 · Cited by 65
Ligand Binding and Activation of Rat Nicotinic α4β2 Receptors Stably Expressed in HEK293 Cells
Sabey, K., Paradiso, K. G., Zhang, J., & Steinbach, J. H. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.1.58 · Cited by 66
Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence
Li, M. D., Lou, X., Chen, G., Ma, J. Z., & Elston, R. C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.026 · Cited by 64
Nicotinic AChR in Subclassified Capsaicin-Sensitive and -Insensitive Nociceptors of the Rat DRG
Rau, K. K., Johnson, R. D., & Cooper, B. Y. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00591.2004 · Cited by 64
Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death
LaLone, C. A., Villeneuve, D. L., Wu-Smart, J. Y., Milsk, R. Y., Sappington, K. G., Garber, K. V., Housenger, J., & Ankley, G. T. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.01.113 · Cited by 67
The subunit composition and pharmacology of α-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay
Salminen, O., Whiteaker, P., Grady, S. R., Collins, A. C., McIntosh, J. M., & Marks, M. J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.12.011 · Cited by 63
Pharmacological Comparison of Transient and Persistent [3H]Dopamine Release from Mouse Striatal Synaptosomes and Response to Chronic l-Nicotine Treatment
Grady, S. R., Grun, E. U., Marks, M. J., & Collins, A. C. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36799-0 · Cited by 65
Specificity of the Effect of a Nicotinic Receptor Polymorphism on Individual Differences in Visuospatial Attention
Greenwood, P. M., Fossella, J., & Parasuraman, R. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/089892905774597281 · Cited by 64
The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: A review
Crunelle, C. L., Miller, M. L., Booij, J., & van den Brink, W. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.001 · Cited by 66
Cognitive Deficits in Schizophrenia: Focus on Neuronal Nicotinic Acetylcholine Receptors and Smoking
Ochoa, E. L. M., & Lasalde‐Dominicci, J. A. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9149-x · Cited by 64
Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors
Nishizaki, T., Nomura, T., Matsuoka, T., Enikolopov, G., & Sumikawa, K. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00117-5 · Cited by 64
The role of the cholinergic system in the development of the human cerebellum
COURT, J. A., Perry, E. K., Spurden, D., Griffiths, M., Kerwin, J. M., Morris, C. M., Johnson, M., Oakley, A. E., Birdsall, N. J. M., Clementi, F., et al. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(96)83496-1 · Cited by 65
Changes in brain 11C–nicotine binding sites in patients with mild Alzheimer’s disease following rivastigmine treatment as assessed by PET
Kadir, A., Darreh‐Shori, T., Almkvist, O., Wall, A. E., Långström, B., & Nordberg, A. K. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0725-z · Cited by 63
The Activation and Inhibition of Human Nicotinic Acetylcholine Receptor by RJR‐2403 Indicate a Selectivity for the α4β2 Receptor Subtype
Papke, R. L., Webster, J. C., Lippiello, P. M., Bencherif, M., & Francis, M. M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750204.x · Cited by 63
Identification of motor areas of the cat cerebral cortex based on studies of cortical stimulation and corticospinal connections
Ghosh, S. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970407)380:2 · Cited by 53
Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.
Raybuck, J. D., Portugal, G. S., Lerman, C., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012601 · Cited by 62
Nicotine addiction: insights from recent animal studies
Mathieu-Kia, A.-M., Kellogg, S. H., Butelman, E. R., & Kreek, M. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1096-0 · Cited by 63
Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies
Pandya, A. A., & Yakel, J. L. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.018 · Cited by 65
The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)3(β2)2 Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)2(β2)3 Subtype
Eaton, J. B., Lucero, L. M., Stratton, H. J., Chang, Y., Cooper, J. F., Lindstrom, J. M., Lukas, R. J., & Whiteaker, P. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.208389 · Cited by 63
Addiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61

Authors: Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J.
Affiliations: Georgetown University Medical Center (US)
University of Colorado Denver (US)
Georgetown University (US)
ORCID: Kellar, K J
Venue: Molecular Pharmacology
Publisher: Elsevier BV
Published: 1992-01
Volume: 41
Issue: 1
Pages: 31-37
ISSN: 0026-895X (ISSN-L)
DOI: 10.1016/s0026-895x(25)08832-7
OpenAlex: W2116249462
Cited by: 880
References: 0
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 18 · 2015: 25 · 2014: 25 · 2013: 22 · 2012: 21
FWCI: 8.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed
Funders: National Institutes of Health (5r01ag009884-05, 5r01da006486-10, 5r01ns011549-24)
National Institute on Aging (AG 09884)
National Institute on Drug Abuse (DA-06486)
National Institute of Neurological Disorders and Stroke (NS11549)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, receptor subunit composition, chronic nicotine treatment, receptor up-regulation, rat cortex, forebrain, neuronal nicotinic receptors
MeSH terms: Quinolizidine Alkaloids, Alkaloids, Animals, Antibodies, Azocines, Brain, Kinetics, Male, Nicotine, Precipitin Tests, Quinolizines, Rats, Inbred Strains, Receptors, Nicotinic, Time Factors, Tritium, Up-Regulation, Macromolecular Substances, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks