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Transport of brain-derived neurotrophic factor across the blood–brain barrier
Abstract
Brain-derived neurotrophic factor (BDNF) is a potential therapeutic agent for degenerative disorders of the central nervous system. In this report, we investigated the ability of BDNF to cross the blood-brain barrier (BBB). BDNF was stable in blood up to 60 min after i.v. injection, with evidence for aggregation, and had an early, rapid influx into brain. By 10 min, most of the BDNF sequestered by the cerebral cortex was associated with the parenchyma rather than with the endothelial cells, demonstrating complete passage across the BBB. A small dose of unlabeled BDNF enhanced the entry of 125I-BDNF from blood to brain after an i.v. bolus injection, whereas larger doses had no effect. In contrast, a large dose of unlabeled BDNF inhibited the influx of 125I-BDNF during in situ brain perfusion. After intracerebroventricular injection, the efflux of BDNF from brain to blood occurred at a rate similar to that for reabsorption of cerebrospinal fluid, and no evidence for self-inhibition was found. Therefore, we conclude that intact BDNF in the peripheral circulation crosses the BBB by a high-capacity, saturable transport system.
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In the citing paper
“BDNF can also enter the brain via freely diffusing across the blood brain barrier (Pan et al., 1998; Mousavi and Jasmin, 2006).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Pan et al., 1998
In the citing paper
“BDNF crosses the blood-brain barrier with high capacity and is highly stable over time, thus serum BDNF is reflective of central nervous system levels [5], [13], [14].”
From Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia (2017) · cites this paper as [13]
In the citing paper
“An important finding is that peripheral BDNF is able to cross the blood-brain barrier [196]”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [196]
Citations
Cites
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
Patlak, C. S., Blasberg, R. G., & Fenstermacher, J. D. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.1 · Cited by 3,565
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921
Passage of cytokines across the blood–brain barrier
Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778
Self-citationPoduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614
Physiology of the CSF and Blood-Brain Barriers
Davson, H., & Segal, M. B. (1996) · Medical Entomology and Zoology · Cited by 582
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577
Self-citationTransport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
Blasberg, R. G., Fenstermacher, J. D., & Patlak, C. S. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.2 · Cited by 517
Banks, W. A., Ortiz, L., Plotkin, S. R., & Kastin, A. J. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20576-6 · Cited by 474
Self-citationXu, X., Guénard, V., Kleitman, N., Aebischer, P., & Bunge, M. B. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1056 · Cited by 469
Triguero, D., Buciak, J. L., & Pardridge, W. M. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04886.x · Cited by 454
Cited by
Sorted by citations
Items 901–1,000 of 1,000
Chang, Y., Wang, T., Lee, S.-Y., Chen, S., Huang, C., Chen, P. S., Yang, Y. K., Hong, J., & Lu, R. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00583 · Cited by 12
Pisu, M. G., Boero, G., Garau, A., Casula, C., Cisci, S., Biggio, F., Concas, A., Follesa, P., Maciocco, E., Porcu, P., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107686 · Cited by 14
Hypothesized Mechanisms Through Which Exercise May Attenuate Memory Interference
Crawford, L. K., Li, H., Zou, L., Wei, G., & Loprinzi, P. D. (2020) · Medicina · doi:10.3390/medicina56030129 · Cited by 14
BDNF: a regulator of learning and memory processes with clinical potential
Brigadski, T., & Leßmann, V. (2014) · e-Neuroforum · doi:10.1515/s13295-014-0053-9 · Cited by 13
Tsai, S. (2012) · Medical Science Monitor · doi:10.12659/msm.883251 · Cited by 12
Pizarro, J. M., Chang, W. E., Bah, M. J., Wright, L. K. M., Saviolakis, G. A., Alagappan, A., Robison, C. L., Shah, J., Meyerhoff, J. L., Cerasoli, D. M., et al. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfr353 · Cited by 12
Ozturk, O., Başay, B. K., Büber, A., Başay, Ö., Alaçam, H., Bacanlı, A., Yılmaz, Ş. G., Erdal, M. E., Herken, H., & Ercan, E. S. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.5.518 · Cited by 13
Văcăraș, V., Major, Z. Z., & Buzoianu, A. D. (2017) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2017.03.002 · Cited by 12
Calle, M., Wang, L., Kuijpers, F. J., Cruijsen, P. M. J. M., Arckens, L., & Roubos, E. W. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01433.x · Cited by 12
Huang, Y., Peng, D., Geng, H., Dai, Y., Jiang, H., & Zhang, X. (2021) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2021.07.009 · Cited by 11
The Neurobiological Links between Stress and Traumatic Brain Injury: A Review of Research to Date
Zheng, L., Pang, Q., Xu, H., Guo, H., Liu, R., & Wang, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179519 · Cited by 12
Red foxtail millet upregulates brain-derived neurotrophic factor levels in vitro and in vivo
NAKAJIMA, K., TOMOHIRO, H., & Oiso, S. (2023) · Biomedical Research · doi:10.2220/biomedres.44.97 · Cited by 11
Epigenetic aging in major depressive disorder: Clocks, mechanisms and therapeutic perspectives
Shaikh, M., & Doshi, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176757 · Cited by 13
Sun, Y., Shi, X., Ohm, M., Körte, M., & Zagrebelsky, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-95546-1 · Cited by 11
Heras, B. D. L., Rodrigues, L., Cristini, J., Yu, E., Gan‐Or, Z., Arbour, N., Thiel, A., Tang, A., Fung, J., Eng, J. J., et al. (2025) · Neurorehabilitation and neural repair · doi:10.1177/15459683251342150 · Cited by 13
Ko, H. M., Jin, Y., Park, H. H., Lee, J. H., Jung, S. H., Choi, S. Y., Lee, S. H., & Shin, C. Y. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.6.679 · Cited by 12
Kranaster, L., Hellweg, R., & Sartorius, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.023 · Cited by 11
Nakajima, K., Oiso, S., & Kariyazono, H. (2020) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.66.284 · Cited by 11
The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
Plinta, K., Plewka, A., Pawlicki, K., Zmarzły, N., Wójcik-Pędziwiatr, M., Rudziński, M., Krzak-Kubica, A., Doręgowska, M., & Rudzińska, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215181 · Cited by 11
Li, L., Wang, X., Guo, J., Chen, Y., & Wang, Z. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1167620 · Cited by 11
Etnier, J. L., Labban, J. D., Karper, W. B., Wideman, L., Piepmeier, A. T., Shih, C.-H., Castellano, M., Williams, L. M., Park, S.-Y., Henrich, V. C., et al. (2015) · Journal of Aging and Physical Activity · doi:10.1123/japa.2014-0221 · Cited by 12
Nowacka-Chmielewska, M. M., Liśkiewicz, D., Paul-Samojedny, M., Bielecka, A., Barski, J. J., Małecki, A., & Obuchowicz, E. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.01.004 · Cited by 10
Skibińska, M., Kapelski, P., Rajewska‐Rager, A., Szczepankiewicz, A., Narożna, B., Duda, J., Budziński, B., Hauser, J., Dmitrzak‐Węglarz, M., & Pawlak, J. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.041 · Cited by 11
Brain Derived Neurotrophic Factor as a Non-invasive Biomarker for Detection of Endometriosis
Dwiningsih, S. R., Meilani, C., & Hadi, S. (2022) · Journal of Reproduction & Infertility · doi:10.18502/jri.v23i3.10012 · Cited by 11
[BDNF measurement in stress-related mood disorders: a review of clinical studies].
Aydemır, Ö., & Deveci, A. (2009) · PubMed · Cited by 10
Regulation of AMPA receptor trafficking by secreted protein factors
Rennich, B. J., Luth, E. S., Moores, S., & Juo, P. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1271169 · Cited by 10
Tsukamoto, H., Ishibashi, A., Marley, C. J., Shinohara, Y., Ando, S., Bailey, D. M., Hashimoto, T., & Ogoh, S. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00059.2020 · Cited by 10
Chycki, J., Zając, A., & Toborek, M. J. (2021) · Biology of Sport · doi:10.5114/biolsport.2020.96320 · Cited by 11
Silveira-Rodrigues, J. G., Nogueira, N. G. D. H. M., Faria, L. O., Pereira, D. S., & Soares, D. D. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2069-4050 · Cited by 10
BDNF and Cognitive Function in Chilean Schizophrenic Patients
Nieto, R. R., Hernán Silva, I., Armijo, A., Nachar, R., González, A., Castañeda, C. P., Montes, C., & Manuel Kukuljan, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310569 · Cited by 10
Leung, W. K. C., Yau, S., Suen, L. K. P., & Lam, S. C. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076118 · Cited by 10
Serum brain-derived neurotrophic factor levels and psychotic symptoms in heroin dependence
Han, B., Zhang, X. Y., Wang, D. Y., Ren, W., Gu, Y., Zhu, L., Chang, Y., Wang, L. P., Wu, C., Jin, Q. Q., et al. (2015) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2015.06.008 · Cited by 10
Huang, X., Huang, X., Zhou, Y., He, H., Mei, F., Sun, B., Soares, J. C., & Zhang, X. Y. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.07.076 · Cited by 10
Lin, C. C., Lee, C. T., Sun, M. H., & Huang, T. L. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000297 · Cited by 11
Kethawath, S. M., Jain, R., Dhawan, A., & Sarkar, S. (2020) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_134_19 · Cited by 10
Mindt, S., Neumaier, M., Hellweg, R., Sartorius, A., & Kranaster, L. (2020) · Journal of Ect · doi:10.1097/yct.0000000000000667 · Cited by 10
Rehman, N. U., Esmaeilpour, K., Joushi, S., Abbas, M., al‐Rashida, M., Rauf, K., & Masoumi‐Ardakani, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110783 · Cited by 10
Connecting Mind-Body Therapy-Mediated Effects to Pathological Features of Alzheimer’s Disease
Hüttenrauch, M., López‐Noguerola, J. S., & Castro‐Obregón, S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200743 · Cited by 10
Emet, D. C., Özön, A., Alikaşifoğlu, A., Kandemir, N., & Gonc, N. E. (2021) · Obesity · doi:10.1002/oby.23087 · Cited by 10
Soloey-Nilsen, H., Nygaard-Odeh, K., Kristiansen, M. G., Brekke, O., Mollnes, T. E., Reitan, S. K., & Øiesvold, T. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03744-2 · Cited by 10
Jennen, L., Mazereel, V., Lecei, A., Samaey, C., Vancampfort, D., & van Winkel, R. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0156 · Cited by 13
Mood Disorders and BDNF Relationship with Alcohol Drinking Trajectories among PLWH Receiving Care
LaForest, D. (2014) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000148 · Cited by 10
Alterations in Serum BDNF Levels in Early Alcohol Withdrawal and Comparison with Healthy Controls
Çavuş, S. Y., Dılbaz, N., Darçın, A. E., Eren, F., Kaya, H., & Kaya, O. (2012) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20120731055756 · Cited by 10
Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder
Nery, F. G., Gigante, A. D., Amaral, J. A., Fernandes, F. B. F., Berutti, M., de Almeida, K. M., Stertz, L., Bristot, G., Kapczinski, F. P., & Lafer, B. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1801 · Cited by 10
Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia
Janicijevic, S. M., Dejanovic, S. D., & Borovčanin, M. (2018) · Serbian Journal of Experimental and Clinical Research · doi:10.1515/sjecr-2017-0031 · Cited by 10
Schmalhofer, M., Markus, M. R. P., Gras, J. C., Kopp, J., Janowitz, D., Grabe, H. J., Groß, S., Ewert, R., Gläser, S., Albrecht, D., et al. (2019) · Biomolecules · doi:10.3390/biom9100630 · Cited by 13
Serum BDNF levels increase during early drug withdrawal in alcohol and crack cocaine addiction
Ornell, F., Scherer, J. N., Schuch, J. B., Sordi, A. O., Halpern, S. C., Rebelatto, F. P., Bristot, G., Kapczinski, F., Roglio, V. S., Pechansky, F., et al. (2023) · Alcohol · doi:10.1016/j.alcohol.2023.04.001 · Cited by 9
Islamic praying changes stress-related hormones and genes
Sobhani, V., Manshadi, E. M., Aghajani, J., & Hatef, B. (2022) · Journal of Medicine and Life · doi:10.25122/jml-2021-0167 · Cited by 15
Işık, M., Köse, F., Budak, Ö., Özbayer, C., KELEŞ, R., Aydın, S., Küçük, A. C., Demirci, M. A., Doğanay, S., & Bağcı, C. (2025) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-025-03084-6 · Cited by 12
Plasma Brain-Derived Neurotrophic Factor and Psychopathology in Attempted Suicide
Ambrus, L., Sunnqvist, C., Ekman, R., Träskman‐Bendz, L., & Westrin, Å. (2016) · Neuropsychobiology · doi:10.1159/000446286 · Cited by 9
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Moaveni, A., Feyzi, Y. F., Rahideh, S. T., & Arezoomandan, R. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136478 · Cited by 10
Qian, F., Liu, J., Yang, H., Zhu, H., Wang, Z., Wu, Y., & Cheng, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.987244 · Cited by 9
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Fay, J. M., & Kabanov, A. V. (2022) · Reviews and Advances in Chemistry · doi:10.1134/s2634827622600177 · Cited by 10
Zhao, T., Tang, S., Gao, X., Li, J., Hao, R., Chen, H.-Z., & Huang, G. (2023) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1982 · Cited by 9
Verbeken, M., Wynendaele, E., Mauchauffée, E., Bracke, N., Stalmans, S., Bojnik, E., Benyhe, S., Peremans, K. Y., Polis, I., Burvenich, C., et al. (2014) · Peptides · doi:10.1016/j.peptides.2014.10.010 · Cited by 9
de Mello, A. S., da Silva, I. R. V., Reinaldo, G. P., Dorneles, G. P., Cé, J., Lago, P. D., Peres, A., Elsner, V. R., & Coelho, J. C. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.11.014 · Cited by 9
Primavera, D., Manchia, M., Deriu, L., Tusconi, M., Collu, R., Scherma, M., Fadda, P., Fratta, W., & Carpiniello, B. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014938 · Cited by 8
Santos, A. M. D. S., Kelly, J. P., & Doyle, K. (2017) · Neuropsychobiology · doi:10.1159/000480513 · Cited by 9
Hachisu, M., Hashizume, M., Kawai, H., Hirano, H., Kojima, M., Fujiwara, Y., Obuchi, S. P., & Ihara, K. (2017) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13210 · Cited by 9
The influence of aging on the methylation status of brain‐derived neurotrophic factor gene in blood
Ihara, K., Fuchikami, M., Hashizume, M., Okada, S., Kawai, H., Obuchi, S., Hirano, H., Fujiwara, Y., Hachisu, M., Kim, H., et al. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4927 · Cited by 9
Roviš, D., Černelič-Bizjak, M., Vasiljev, V., Petelin, A., Jenuš, T., Vidic, S., Drevenšek, G., & Pražnikar, Z. J. (2018) · European Addiction Research · doi:10.1159/000492582 · Cited by 10
Multiple epigenetic biomarkers for evaluation of students' academic performance
Lee, L., Su, M., Cho, Y., Lee‐Chen, G., Yeh, T., & Chang, C. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12559 · Cited by 8
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Adam, O., Psomiades, M., Rey, R., Mandairon, N., Suaud‐Chagny, M., Mondino, M., & Brunelin, J. (2021) · Brain Sciences · doi:10.3390/brainsci11050662 · Cited by 10
Figueiredo, A. I., da Cunha, J. J., da Silva, I. R. V., Martins, L. L., Bard, A. L., Reinaldo, G. P., Elsner, V. R., & de Souza, M. P. (2017) · Middle East Journal of Rehabilitation and Health Studies · doi:10.5812/mejrh.57486 · Cited by 9
Ranjbar, N., Shahbazi, A., Nourizadeh, N., Arefi, H. N., & Kheirkhah, M. T. (2023) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-023-03600-z · Cited by 8
Wang, C., Jia, X., Jin, H. L., Meng, Y., Ye, W., Zhang, N., Wang, W., Kan, H., & Zhang, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114912 · Cited by 8
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Li, R., Qü, P., Hu, X., Li, X., Zeng, H., Gao, B., & Sun, Z. (2024) · PeerJ · doi:10.7717/peerj.18306 · Cited by 8
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Cadoret, A., Dion‐Albert, L., Amrani, S., Caron, L., Théberge, M., Turmel, A., Lebel, M., & Ménard, C. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114443 · Cited by 8
Ballestar‐Tarín, M. L., Valle, V. I.-D., Mafla-España, M. A., Navarro-Martínez, R., & Cauli, O. (2024) · Diagnostics · doi:10.3390/diagnostics14040447 · Cited by 11
Pham, A. T., Peterson, R., Slaughter, S., Martin, M., Hippensteel, J. A., & Burnham, E. L. (2025) · CHEST Critical Care · doi:10.1016/j.chstcc.2025.100143 · Cited by 8
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Szabo, A. J., Alosco, M. L., Miller, L. A., McGeary, J. E., Poppas, A., Cohen, R. A., & Gunstad, J. (2013) · Psychogeriatrics · doi:10.1111/psyg.12013 · Cited by 8
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Kobayakawa, M., Inagaki, M., Fujimori, M., Hamazaki, K., Hamazaki, T., Akechi, T., Tsugane, S., Nishiwaki, Y., Goto, K., Hashimoto, K., et al. (2011) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyr119 · Cited by 8
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Metadata
- Authors
- Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J.
- Affiliations
- Tulane University (US)
- St. Louis VA Medical Center (US)
- Corresponding author
- Pan, Weihong
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 37
- Issue
- 12
- Pages
- 1553-1561
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1972280500
- Cited by
- 1,354
- References
- 25
- Citations by year
- 2026: 33 · 2025: 53 · 2024: 85 · 2023: 64 · 2022: 63 · 2021: 100 · 2020: 89 · 2019: 77 · 2018: 66 · 2017: 76 · 2016: 82 · 2015: 65 · 2014: 78 · 2013: 62 · 2012: 53
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, blood-brain barrier, saturable transport, cerebral cortex, cerebrospinal fluid reabsorption, neurotrophic therapy
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Capillaries, Cerebrovascular Circulation, Humans, Injections, Intravenous, Iodine Radioisotopes, Kinetics, Male, Mice, Inbred ICR, Recombinant Proteins, Regression Analysis, Technetium Tc 99m Aggregated Albumin, Time Factors, Brain-Derived Neurotrophic Factor, Mice
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