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Transport of brain-derived neurotrophic factor across the blood–brain barrier
Abstract
Brain-derived neurotrophic factor (BDNF) is a potential therapeutic agent for degenerative disorders of the central nervous system. In this report, we investigated the ability of BDNF to cross the blood-brain barrier (BBB). BDNF was stable in blood up to 60 min after i.v. injection, with evidence for aggregation, and had an early, rapid influx into brain. By 10 min, most of the BDNF sequestered by the cerebral cortex was associated with the parenchyma rather than with the endothelial cells, demonstrating complete passage across the BBB. A small dose of unlabeled BDNF enhanced the entry of 125I-BDNF from blood to brain after an i.v. bolus injection, whereas larger doses had no effect. In contrast, a large dose of unlabeled BDNF inhibited the influx of 125I-BDNF during in situ brain perfusion. After intracerebroventricular injection, the efflux of BDNF from brain to blood occurred at a rate similar to that for reabsorption of cerebrospinal fluid, and no evidence for self-inhibition was found. Therefore, we conclude that intact BDNF in the peripheral circulation crosses the BBB by a high-capacity, saturable transport system.
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In the citing paper
“BDNF can also enter the brain via freely diffusing across the blood brain barrier (Pan et al., 1998; Mousavi and Jasmin, 2006).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Pan et al., 1998
In the citing paper
“BDNF crosses the blood-brain barrier with high capacity and is highly stable over time, thus serum BDNF is reflective of central nervous system levels [5], [13], [14].”
From Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia (2017) · cites this paper as [13]
In the citing paper
“An important finding is that peripheral BDNF is able to cross the blood-brain barrier [196]”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [196]
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Cites
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
Patlak, C. S., Blasberg, R. G., & Fenstermacher, J. D. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.1 · Cited by 3,565
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921
Passage of cytokines across the blood–brain barrier
Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778
Self-citationPoduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614
Physiology of the CSF and Blood-Brain Barriers
Davson, H., & Segal, M. B. (1996) · Medical Entomology and Zoology · Cited by 582
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577
Self-citationTransport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
Blasberg, R. G., Fenstermacher, J. D., & Patlak, C. S. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.2 · Cited by 517
Banks, W. A., Ortiz, L., Plotkin, S. R., & Kastin, A. J. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20576-6 · Cited by 474
Self-citationXu, X., Guénard, V., Kleitman, N., Aebischer, P., & Bunge, M. B. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1056 · Cited by 469
Triguero, D., Buciak, J. L., & Pardridge, W. M. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04886.x · Cited by 454
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Walsh, J. J., D’Angiulli, A., Cameron, J. D., Sigal, R. J., Kenny, G. P., Holčı́k, M., Doucette, S. P., Alberga, A. S., Prud’homme, D., Hadjiyannakis, S., et al. (2018) · Neural Plasticity · doi:10.1155/2018/7169583 · Cited by 31
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Perković, M. N., Borovečki, F., Filipčić, I., Vuić, B., Milos, T., Erjavec, G. N., Konjevod, M., Tudor, L., Mimica, N., Uzun, S., et al. (2023) · Biomolecules · doi:10.3390/biom13030570 · Cited by 34
Kadoya, M., Koyama, H., Kanzaki, A., Kurajoh, M., Hatayama, M., Shiraishi, J., Okazaki, H., Shoji, T., Moriwaki, Y., Yamamoto, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105977 · Cited by 31
Spulber, S. D., Rantamäki, T., Nikkilä, O., Ċastrén, E., Weihe, P., Grandjean, P., & Ceccatelli, S. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq216 · Cited by 31
Popp, E., Padosch, S. A., Vogel, P., Schabitz, W. R., Schwab, S., & Böttiger, B. W. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000134223.09056.fc · Cited by 31
Roh, E., Hwang, S. Y., Song, E., Park, M., Yoo, H. J., Baik, S. H., Kim, M., Won, C. W., & Choi, K. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-19706-3 · Cited by 32
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Gholami, F., Mesrābādi, J., Iranpour, M., & Donyaei, A. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112658 · Cited by 38
Şimşek, Ş., Uysal, C., Kaplan, İ., Yüksel, T., & Aktaş, H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.02.017 · Cited by 32
Murphy, B., Pang, T. Y., Hannan, A. J., Proffitt, T., McConchie, M., Kerr, M., Markulev, C., O’Donnell, C. P., McGorry, P. D., & Berger, G. E. (2014) · Schizophrenia Research and Treatment · doi:10.1155/2014/719395 · Cited by 30
Nguyen, L. T., Reverter, A., Cánovas, Á., Venus, B. K., Anderson, S. T., Islas‐Trejo, A., Barbero, M. M. D., Crawford, N. F., Lehnert, S. A., Medrano, J. F. F., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00087 · Cited by 31
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Wang, D., Li, H., Du, X., Zhou, J., Liu, Y., Ren, H., Yang, X., Zhang, G., & Chen, X. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.514658 · Cited by 33
Massa, N., Alrohaibani, A., Mammino, K., Bello, M., Taylor, N., Cuthbert, B. N., Fargotstein, M., Coulter, M. M., Boatright, J. H., Nocera, J. R., et al. (2019) · Brain Plasticity · doi:10.3233/bpl-200105 · Cited by 35
Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges
Omar, N. A., Kumar, J., & Teoh, S. L. (2022) · Neuropeptides · doi:10.1016/j.npep.2022.102226 · Cited by 31
Nejtek, V. A., Hilburn, C., Gangwani, P., Underwood, W., Singh, M., Patel, G., & Forster, M. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s18953 · Cited by 30
Cao, T., Li, N., & Cai, H. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.03.009 · Cited by 30
Ng, D. Q., Chan, D., Agrawal, P., Zhao, W., Xu, X., Acharya, M. M., & Chan, A. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103748 · Cited by 31
Liu, Y.-H., Jiao, S.-S., Wang, Y.-R., Bu, X.-L., Yao, X., Xiang, Y., Wang, Q.-H., Wang, L., Deng, J., Li, J., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8804-8 · Cited by 30
BDNF, endurance activity, and mechanisms underlying the evolution of hominin brains
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László, A., Lénárt, L., Illésy, L., Fekete, A., & Nemcsik, J. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01973-6 · Cited by 33
Cavalcante, M. M., Fraga, I. B., Dalbosco, B., Marchi, P. D., Iraci, L., da Silva, M. E. B., Dani, C., Bosco, A. D., & Elsner, V. R. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113589 · Cited by 30
Burnouf, T., Kuo, Y., Blum, D. L., Burnouf, S., & Su, C. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03494.x · Cited by 31
Karczewska‐Kupczewska, M., Strączkowski, M., Adamska, A., Nikołajuk, A., Otziomek, E., Górska, M., & Kowalska, I. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.05.008 · Cited by 29
Deveci, A., Aydemır, Ö., Taşkın, O., Taneli, F., & Esen-Danacı, A. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01710.x · Cited by 29
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Gevaert, B., Wynendaele, E., Stalmans, S., Bracke, N., D’Hondt, M., Smolders, I. J., Eeckhaut, A. V., & Spiegeleer, B. M. J. D. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.051 · Cited by 29
Lira, F. S., de Freitas, M. C., Gerosa-Neto, J., Cholewa, J. M., & Rossi, F. E. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002653 · Cited by 29
Peptide transport across the blood-brain barrier
Kastin, A. J., & Pan, W. (2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8049-7_3 · Cited by 30
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Li, Z., Dang, Q., Wang, P., Zhao, F., Huang, J., Wang, C., Liu, X., & Min, W. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06518 · Cited by 29
Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29
Lee, I., Fu, C., Lee, W., Liang, K., Lin, S., Wan, C., & Sheu, W. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-18 · Cited by 29
Lee, S.-Y., Wang, T., Chen, S., Chang, Y.-H., Chen, P. S., Huang, S., Tzeng, N., Wang, L., Lee, I. H., Chen, K. C., et al. (2016) · Scientific Reports · doi:10.1038/srep37950 · Cited by 27
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Baumeister, D., Eich, W., Saft, S., Geisel, O., Hellweg, R., Finn, A., Svensson, C. I., & Tesarz, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-49403-7 · Cited by 28
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Poniatowski, Ł. A., Cudna, A., Kurczych, K., Bronisz, E., & Kurkowska‐Jastrzębska, I. (2021) · Epilepsy Research · doi:10.1016/j.eplepsyres.2021.106612 · Cited by 28
Suwa, M., Yamamoto, K.-I., Nakano, H., Sasaki, H., Radak, Z. O., & Kumagai, S. (2010) · Physiological Research · doi:10.33549/physiolres.931784 · Cited by 32
Skilleter, A. J., Weickert, C. S., Vercammen, A., Lenroot, R., & Weickert, T. W. (2014) · Psychological Medicine · doi:10.1017/s0033291714001925 · Cited by 27
Gourgouvelis, J., Yielder, P. C., Clarke, S. T., Behbahani, H., & Murphy, B. A. (2018) · PeerJ · doi:10.7717/peerj.4675 · Cited by 30
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Enstrom, A. M., Onore, C. E., Tarver, A., Hertz‐Picciotto, I., Hansen, R. L., Croen, L., de Water, J. V., & Ashwood, P. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.121.129 · Cited by 28
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Shen, R., Ardianto, C., Celia, C., Sidharta, V. M., Sasmita, P. K., Satriotomo, I., & Turana, Y. (2023) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2023-0012 · Cited by 31
Nubukpo, P., Ramoz, N., Girard, M. F., Malauzat, D., & Gorwood, P. A. P. M. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13414 · Cited by 30
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Dhavamani, S., Yalagala, P. C. R., & Subbaiah, P. V. (2020) · Scientific Reports · doi:10.1038/s41598-020-67868-9 · Cited by 28
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Chung, C., Huang, P. H., Chan, L., Chen, J., Chien, L., & Hong, C. (2020) · Diagnostics · doi:10.3390/diagnostics10090684 · Cited by 27
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Devasahayam, A. J., Kelly, L. P., Williams, J. B., Moore, C. S., & Ploughman, M. (2021) · Biomolecules · doi:10.3390/biom11040504 · Cited by 32
Li, L., Wang, T., Chen, S., Yue, Y., Xu, Z., & Yuan, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.016 · Cited by 27
Chu, C., Liang, C., Chou, M.-Y., Lin, Y.-T., Pan, C., Lu, T., Chen, L., & Chow, P. C. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.08.006 · Cited by 28
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Russo, N., Russo, M., Daino, D., Bucci, F., Pluchino, N., Casarosa, E., Artini, P. G., Cela, V., Luisi, M., & Genazzani, A. R. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.613969 · Cited by 27
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Skibińska, M., Groszewska, A., Kapelski, P., Rajewska‐Rager, A., Pawlak, J., Dmitrzak‐Węglarz, M., Szczepankiewicz, A., & Hauser, J. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.08.002 · Cited by 26
Zhen, Y., Liu, X., Zhou, D., Du, X., Yin, G., Zhang, Y., Fang, H., Xu, G., Soares, J. C., & Zhang, X. Y. (2017) · Oncotarget · doi:10.18632/oncotarget.23342 · Cited by 27
Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus
Goto, F., Saruta, J., Kanzaki, S., To, M., Tsutsumi, T., Tsukinoki, K., & Ogawa, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.001 · Cited by 27
Vedovelli, K., Silveira, E., Velho, E., Stertz, L., Kapczinski, F., Schröder, N., & Bromberg, E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.012 · Cited by 26
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Grande, I., Magalhães, P. V. D. S., Chendo, I., Stertz, L., Fries, G. R., Ceresér, K. M. M., Cunha, A. B. M., Goi, P. D., Kunz, M., Udina, M., et al. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12192 · Cited by 28
Chen, S., Lee, S.-Y., Chang, Y.-H., Wang, T., Chen, S., Chu, C., Chen, P. S., Yang, Y. K., Hong, J., & Lu, R. (2015) · Scientific Reports · doi:10.1038/srep08148 · Cited by 28
Luo, L., Jiang, X., Cao, G., Xiong, P., Yang, R. Z., Zhang, J., & Shen, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.017 · Cited by 26
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizábal, C. L., Petyuk, V., Adams, H. H. H., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa176 · Cited by 26
Dangat, K. D., Kilari, A. S., Mehendale, S. S., Lalwani, S. K., & Joshi, S. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.12.007 · Cited by 26
Kudlek Mikulic, S., Mihaljevic-Peles, A., Sagud, M., Bajs Janovic, M., Ganoci, L., Grubisin, J., Kuzman Rojnic, M., Vuksan Cusa, B., Bradaš, Z., & Božina, N. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1340518 · Cited by 25
Tsai, C., Chan, J. Y. H., Hsu, K., Chang, A. Y., & Chan, S. H. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033527 · Cited by 25
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Wu, C., Lü, J., Lu, S., Huang, M., & Xu, Y. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.05.010 · Cited by 25
Blood Markers Show Neural Consequences of LongCOVID-19
Tang, N., Kido, T., Shi, J., McCafferty, E., Ford, J. M., Bon, K. D., & Pulliam, L. (2024) · Cells · doi:10.3390/cells13060478 · Cited by 25
Chalimoniuk, M., Chrapusta, S. J., Lukáčová, N., & Langfort, J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.05.020 · Cited by 25
Geoffroy, H., & Noble, F. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.10.009 · Cited by 25
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Yang, Y. Q., Sun, S., Yu, Y. Q., Li, W. J., Zhang, X., Xiu, M. H., Chen, D. C., Yang, F. D., Liu, H., Li, C., et al. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.020 · Cited by 24
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Sgritta, M., Vignoli, B., Pimpinella, D., Griguoli, M., Santi, S., Bialowas, A., Wiera, G., Zacchi, P., Malerba, F., Marchetti, C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105728 · Cited by 24
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Metadata
- Authors
- Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J.
- Affiliations
- Tulane University (US)
- St. Louis VA Medical Center (US)
- Corresponding author
- Pan, Weihong
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 37
- Issue
- 12
- Pages
- 1553-1561
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1972280500
- Cited by
- 1,354
- References
- 25
- Citations by year
- 2026: 33 · 2025: 53 · 2024: 85 · 2023: 64 · 2022: 63 · 2021: 100 · 2020: 89 · 2019: 77 · 2018: 66 · 2017: 76 · 2016: 82 · 2015: 65 · 2014: 78 · 2013: 62 · 2012: 53
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, blood-brain barrier, saturable transport, cerebral cortex, cerebrospinal fluid reabsorption, neurotrophic therapy
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Capillaries, Cerebrovascular Circulation, Humans, Injections, Intravenous, Iodine Radioisotopes, Kinetics, Male, Mice, Inbred ICR, Recombinant Proteins, Regression Analysis, Technetium Tc 99m Aggregated Albumin, Time Factors, Brain-Derived Neurotrophic Factor, Mice
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