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Transport of brain-derived neurotrophic factor across the blood–brain barrier
Abstract
Brain-derived neurotrophic factor (BDNF) is a potential therapeutic agent for degenerative disorders of the central nervous system. In this report, we investigated the ability of BDNF to cross the blood-brain barrier (BBB). BDNF was stable in blood up to 60 min after i.v. injection, with evidence for aggregation, and had an early, rapid influx into brain. By 10 min, most of the BDNF sequestered by the cerebral cortex was associated with the parenchyma rather than with the endothelial cells, demonstrating complete passage across the BBB. A small dose of unlabeled BDNF enhanced the entry of 125I-BDNF from blood to brain after an i.v. bolus injection, whereas larger doses had no effect. In contrast, a large dose of unlabeled BDNF inhibited the influx of 125I-BDNF during in situ brain perfusion. After intracerebroventricular injection, the efflux of BDNF from brain to blood occurred at a rate similar to that for reabsorption of cerebrospinal fluid, and no evidence for self-inhibition was found. Therefore, we conclude that intact BDNF in the peripheral circulation crosses the BBB by a high-capacity, saturable transport system.
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In the citing paper
“BDNF can also enter the brain via freely diffusing across the blood brain barrier (Pan et al., 1998; Mousavi and Jasmin, 2006).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Pan et al., 1998
In the citing paper
“BDNF crosses the blood-brain barrier with high capacity and is highly stable over time, thus serum BDNF is reflective of central nervous system levels [5], [13], [14].”
From Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia (2017) · cites this paper as [13]
In the citing paper
“An important finding is that peripheral BDNF is able to cross the blood-brain barrier [196]”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [196]
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Cites
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
Patlak, C. S., Blasberg, R. G., & Fenstermacher, J. D. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.1 · Cited by 3,565
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921
Passage of cytokines across the blood–brain barrier
Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778
Self-citationPoduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614
Physiology of the CSF and Blood-Brain Barriers
Davson, H., & Segal, M. B. (1996) · Medical Entomology and Zoology · Cited by 582
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577
Self-citationTransport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
Blasberg, R. G., Fenstermacher, J. D., & Patlak, C. S. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.2 · Cited by 517
Banks, W. A., Ortiz, L., Plotkin, S. R., & Kastin, A. J. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20576-6 · Cited by 474
Self-citationXu, X., Guénard, V., Kleitman, N., Aebischer, P., & Bunge, M. B. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1056 · Cited by 469
Triguero, D., Buciak, J. L., & Pardridge, W. M. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04886.x · Cited by 454
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Balu, D. T., & Coyle, J. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.005 · Cited by 185
Bocchio‐Chiavetto, L., Zanardini, R., Bortolomasi, M., Abate, M., Segala, M., Giacopuzzi, M., Riva, M. A., Marchina, E., Pasqualetti, P., Pérez, J., et al. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.04.010 · Cited by 189
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Palomino, A., Vallejo‐Illarramendi, A., González-Pinto, A. M., Aldama, A., González‐Gómez, C., Mosquera, F., González-García, G., & Matute, C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.028 · Cited by 180
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Laske, C., Stellos, K., Hoffmann, N., Stransky, E., Straten, G., Eschweiler, G. W., & Leyhe, T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001008 · Cited by 180
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BDNF reverses aging-related microglial activation
Wu, S.-Y., Pan, B.-S., Tsai, S., Chiang, Y.-T., Huang, B., Mo, F., & Kuo, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01887-1 · Cited by 178
Zhang, Y., & Pardridge, W. M. (2001) · Stroke · doi:10.1161/01.str.32.6.1378 · Cited by 175
Huang, T.-L., Lee, C.-T., & Liu, Y.-L. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.05.007 · Cited by 190
Xiu, M. H., Hui, L., Dang, Y. F., Hou, T. D., Zhang, C. X., Zheng, Y. L., Chen, D. C., Kosten, T. R., & Zhang, X. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.08.011 · Cited by 172
Laske, C., Banschbach, S., Stransky, E., Bosch, S., Straten, G., Machann, J., Fritsche, A., Hipp, A., Niess, A., & Eschweiler, G. W. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991234 · Cited by 171
Tsai, C., Chen, F., Pan, C., Wang, C., Huang, T., & Chen, T.-C. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.014 · Cited by 183
Low brain‐derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients
Ciammola, A., Sassone, J., Cannella, M., Calza, S., Poletti, B., Frati, L., Squitieri, F., & Silani, V. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30501 · Cited by 178
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Miao, Z., Wang, Y., & Sun, Z. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041375 · Cited by 186
Monteleone, P., Serritella, C., Martiadis, V., & Maj, M. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00459.x · Cited by 162
Teixeira, A. L., Barbosa, I. G., Diniz, B. S., & Kümmer, A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.111 · Cited by 164
Walsh, E., Smith, L. M., Northey, J. M., Rattray, B., & Cherbuin, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101044 · Cited by 175
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160
Serra, M. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i1.84 · Cited by 166
Roles of myokines in exercise-induced improvement of neuropsychiatric function
Kim, S., Choi, J., Moon, S., Park, D., Kwak, H., & Kang, J. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02253-8 · Cited by 177
Fernandes, B. S., Berk, M., Turck, C. W., Steiner, J. H., & Gonçalves, C.-A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.172 · Cited by 159
Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics
GRILLO, R., Ottoni, G. L., Leke, R., Souza, D. O., Portela, L. V., & Lara, D. R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.005 · Cited by 159
Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease
Leyhe, T., Eschweiler, G. W., Stransky, E., Gasser, T., Annas, P., Basun, H., & Laske, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1004 · Cited by 158
Munkholm, K., Vinberg, M., & Kessing, L. V. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.54 · Cited by 157
Tsai, C., Pai, M., Ukropec, J., & Ukropcová, B. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190228125429 · Cited by 172
Lang, U. E., Hellweg, R., Seifert, F. C., Schubert, F., & Gallinat, J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.002 · Cited by 157
Lactate infusion at rest increases BDNF blood concentration in humans.
Schiffer, T., Schulte, S., Sperlich, B., Achtzehn, S., Fricke, H., & Strüder, H. K. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.035 · Cited by 159
Machado-Vieira, R., Yuan, P., Brutsche, N., DiazGranados, N., Luckenbaugh, D., Manji, H. K., & Zarate, C. A. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04659 · Cited by 155
Pluchino, N., Russo, M., Santoro, A. N., Litta, P., Cela, V., & Genazzani, A. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.025 · Cited by 154
Intensive Rehabilitation Increases BDNF Serum Levels in Parkinsonian Patients
Frazzitta, G., Maestri, R., Ghilardi, M. F., Riboldazzi, G., Perini, M., Bertotti, G., Boveri, N., Buttini, S., Lombino, F. L., Uccellini, D., et al. (2013) · Neurorehabilitation and neural repair · doi:10.1177/1545968313508474 · Cited by 160
Korley, F. K., Diaz-Arrastia, R. R., Wu, A. H. B., Yue, J. K., Manley, G. T., Sair, H. I., Eyk, J. E. V., Everett, A. D., the TRACK-TBI investigators including, Okonkwo, D. O., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.3949 · Cited by 158
Schmidt‐Kassow, M., Deusser, M., Thiel, C., Otterbein, S., Montag, C., Reuter, M., Banzer, W. E., & Kaiser, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064172 · Cited by 157
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Self-citationChen, C., & Nakagawa, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101868 · Cited by 178
Zanardini, R., Gazzoli, A., Ventriglia, M., PEREZ, J., Bignotti, S., MARIAROSSINI, P., Gennarelli, M., & Bocchio‐Chiavetto, L. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.029 · Cited by 147
Tan, Y. L., Zhou, D. F., Cao, L. Y., Zou, Y. Z., & Zhang, X. Y. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.02.054 · Cited by 146
SOUSA, R. T. D., van de Bilt, M. T., Diniz, B. S., Ladeira, R. B., Portela, L. V., Souza, D. O., Forlenza, O. V., Gattaz, W. F., & Machado‐Vieira, R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.054 · Cited by 145
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Arosio, B., Guerini, F. R., Voshaar, R. C. O., & Aprahamian, I. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.626906 · Cited by 156
Shimizu, E., Hashimoto, K., Watanabe, H., Komatsu, N., Okamura, N., Koike, K., 篠田, 直., Nakazato, M., Kumakiri, C., Okada, S.-I., et al. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.08.004 · Cited by 144
Brain-derived neurotrophic factor in patients with multiple sclerosis
Sarchielli, P., Greco, L., Stipa, A., Floridi, A., & Gallai, V. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00319-3 · Cited by 143
Pırıldar, Ş., Gönül, A. S., Taneli, F., & Akdeniz, F. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.008 · Cited by 142
Ikeda, Y., Yahata, N., Ito, I., Nagano, M., Toyota, T., Yoshikawa, T., Okubo, Y., & Suzuki, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.017 · Cited by 143
Christiansen, L., Beck, M. M., Bilenberg, N., Wienecke, J., Astrup, A. V., & Lundbye‐Jensen, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060841 · Cited by 168
Leyhe, T., Stransky, E., Eschweiler, G. W., Buchkremer, G., & Laske, C. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0764-9 · Cited by 140
Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression
Trzeciak, P., & Herbet, M. (2021) · Nutrients · doi:10.3390/nu13030927 · Cited by 139
Harrisberger, F., Smieskova, R., Schmidt, A., Lenz, C., Walter, A., Wittfeld, K., Grabe, H. J., Lang, U. E., Fusar-Poli, P., & Borgwardt, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.017 · Cited by 138
Allen, A. P., Naughton, M., Dowling, J., Walsh, A., Ismail, F., Shorten, G., Scott, L., McLoughlin, D. M., Cryan, J. F., Dinan, T. G., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.033 · Cited by 138
Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137
Brain-derived neurotrophic factor serum levels before and after treatment for acute mania
Tramontina, J., Andreazza, A. C., Kauer‐Sant’Anna, M., Stertz, L., Goi, J. D., Chiarani, F., & Kapczinski, F. P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.028 · Cited by 136
Chen, D. C., Wang, J., Wang, B., Yang, S. C., Zhang, C. X., Zheng, Y. L., Li, Y. L., Wang, N., Yang, K. B., Xiu, M. H., et al. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1665-6 · Cited by 136
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Currie, J. M. S., Ramsbottom, R., Ludlow, H., Nevill, A. M., & Gilder, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.12.043 · Cited by 140
Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder
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Decreased Plasma Brain‐Derived Neurotrophic Factor Levels in Patients With Alcohol Dependence
Joe, K., Kim, Y., Kim, T., Roh, S., Choi, S., Kim, Y.-B., Lee, H., & Kim, D. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00507.x · Cited by 134
Forlenza, O. V., Diniz, B. S., Teixeira, A. L., Ojopi, E. P. B., Talib, L. L., Mendonça, V. A., Izzo, G., & Gattaz, W. F. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003797241 · Cited by 134
Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin
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Nonomura, T., Tsuchida, A., Ono‐Kishino, M., Nakagawa, T., Taiji, M., & Noguchia, H. (2001) · Journal of Diabetes Research · doi:10.1155/edr.2001.201 · Cited by 131
The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels
Ozan, E., Okur, H., Eker, M. C., Eker, Ö. D., Gönül, A. S., & Akarsu, N. A. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.022 · Cited by 132
BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma
Kertes, D. A., Bhatt, S., Kamin, H. S., Hughes, D. A., Rodney, N. C., & Mulligan, C. J. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0367-x · Cited by 131
Low BDNF is associated with cognitive deficits in patients with type 2 diabetes
Zhen, Y. F., Zhang, J., Liu, X. Y., Fang, H., Tian, L. B., Zhou, D. H., Kosten, T. R., & Zhang, X. Y. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2942-3 · Cited by 126
Hyun-Chul, C., Kim, J., Kim, S.-Y., Son, Y. H., Lee, N., & Jung, S. H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.025 · Cited by 132
Zoladz, J. A., Majerczak, J., Żeligowska, E., Mencel, J., Jaskólski, A., Jaskólska, A., & Marusiak, J. (2014) · PubMed · Cited by 127
Zheleznyakova, G. Y., Cao, H., & Schiöth, H. B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0101-4 · Cited by 131
HUANG, T., & Lee, C. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.11.004 · Cited by 127
Elzinga, B. M., Molendijk, M. L., Voshaar, R. C. O., Bus, B. A. A., Prickaerts, J., Spinhoven, P., & Penninx, B. W. J. H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1961-1 · Cited by 128
Begni, V., Riva, M. A., & Cattaneo, A. (2016) · Clinical Science · doi:10.1042/cs20160009 · Cited by 129
Lee, H.-Y., & Kim, Y.-K. (2008) · Neuropsychobiology · doi:10.1159/000149817 · Cited by 132
Angelucci, F., Ricci, V., Pomponi, M., Conte, G., Mathé, A. A., Tonali, P. A., & Bria, P. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107078491 · Cited by 125
Pluchino, N., Cubeddu, A., Begliuomini, S., Merlini, S., Giannini, A., Bucci, F., Casarosa, E., Luisi, M., Cela, V., & Genazzani, A. R. (2009) · Human Reproduction · doi:10.1093/humrep/dep119 · Cited by 124
Decreased BDNF in patients with antipsychotic naïve first episode schizophrenia
Jindal, R. D., Pillai, A. K., Mahadik, S. P., Eklund, K., Montrose, D. M., & Keshavan, M. S. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.035 · Cited by 124
Neshatdoust, S., Saunders, C., Castle, S. M., Vauzour, D., Williams, C. M., Butler, L. T., Lovegrove, J. A., & Spencer, J. P. E. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-1615 · Cited by 128
Alam, A., Suen, K. C., Hana, Z., Sanders, R. D., Maze, M., & Ma, D. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.01.001 · Cited by 120
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Brain Repair and Neuroprotection by Serum Insulin-Like Growth Factor I
Carro, E., Trejo, J. L., Núñez, Á., & Torres‐Alemán, I. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:2:153 · Cited by 122
Wen, K., Milić, J., El‐Khodor, B. F., Dhana, K., Nano, J., Pulido, T., Kraja, B., Začiragić, A., Bramer, W. M., Troup, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167201 · Cited by 130
Inverse Correlation of Brain and Blood BDNF Levels in a Genetic Rat Model of Depression
Elfving, B., Plougmann, P. H., Müller, H. K., Mathé, A. A., Rosenberg, R., & Wegener, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990721 · Cited by 119
Investigation of serum BDNF levels in drug-naive patients with schizophrenia.
Rizos, E., Rontos, I., Laskos, E., Arsenis, G., Michalopoulou, P., Vasilopoulos, D., Gournellis, R., & Lykouras, L. (2008) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.04.007 · Cited by 127
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Gustafsson, G., Lira, C. M., Johansson, J., Wisén, A., Wohlfart, B., Ekman, R., & Westrin, Å. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.030 · Cited by 118
Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Zhang, H., & Pavuluri, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.003 · Cited by 118
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Wang, T., Lee, S.-Y., Chen, S., Chung, Y.-L., Li, C., Chang, Y., Wang, L., Chen, P. S., Chen, S., Chu, C., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw012 · Cited by 120
Briken, S., Rosenkranz, S. C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pleß, O., Schulz, K., & Gold, S. M. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.007 · Cited by 120
Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants
Laske, C., Stransky, E., Eschweiler, G. W., Klein, R., Wittorf, A., Leyhe, T., Richartz, E., Köhler, N., Bartels, M., Buchkremer, G., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.007 · Cited by 118
Rescue of Retinal Function by BDNF in a Mouse Model of Glaucoma
Domenici, L., Origlia, N., Falsini, B., Cerri, E., Barloscio, D., Fabiani, C., Sansò, M., & Giovannini, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115579 · Cited by 117
Khalin, I., Alyautdin, R. N., Wong, T. W., Gnanou, J. V., Kocherga, G., & Kreuter, J. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1199609 · Cited by 121
D’Souza, D. C., Pittman, B. P., Perry, E. B., & Simen, A. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1333-2 · Cited by 117
Maternal serum concentrations of BDNF and depression in the perinatal period
Lommatzsch, M., Hornych, K., Zingler, C., Schuff‐Werner, P., Höppner, J., & Virchow, J. C., Jr. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.09.003 · Cited by 118
Tsai, C., Pan, C., Tseng, Y., Chen, F., Chang, Y.-C., & Wang, T.-C. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113472 · Cited by 123
Lang, U. E., Jockers-Scherübl, M. C., & Hellweg, R. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0100-0 · Cited by 119
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Henriques (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00032 · Cited by 117
Agile delivery of protein therapeutics to CNS
Yi, X., Manickam, D. S., Brynskikh, A. M., & Kabanov, A. V. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.017 · Cited by 116
Zhao, Y., Li, X., Lu, C., Lin, M., Chen, L., Xiang, Q., Zhang, M., Jin, R., Jiang, X., Shen, X., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.10.009 · Cited by 114
Serum cortisol and BDNF in patients with major depression—effect of yoga
Naveen, G., Varambally, S. S., Thirthalli, J., Rao, M. G., Christopher, R., & Gangadhar, B. N. (2016) · International Review of Psychiatry · doi:10.1080/09540261.2016.1175419 · Cited by 120
Küster, O. C., Laptinskaya, D., Fissler, P., Schnack, C., Zügel, M., Nold, V., Thurm, F., Pleiner, S., Karabatsiakis, A., von Einem, B., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170447 · Cited by 122
Rizos, E. N., Παπαδοπούλου, Α., Laskos, E., Michalopoulou, P. G., Kastania, A., Vasilopoulos, D., Katsafouros, K., & Lykouras, L. P. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802182733 · Cited by 113
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Lee, J. G., Shin, B. S., You, Y. S., Kim, J. E., Yoon, S. W., Jeon, D. W., Baek, J. H., Park, S. W., & Kim, Y. H. (2009) · Psychiatry Investigation · doi:10.4306/pi.2009.6.4.299 · Cited by 113
Monteleone, P., Fabrazzo, M., Martiadis, V., Serritella, C., Pannuto, M., & Maj, M. (2004) · Psychological Medicine · doi:10.1017/s0033291704003368 · Cited by 113
Metadata
- Authors
- Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J.
- Affiliations
- Tulane University (US)
- St. Louis VA Medical Center (US)
- Corresponding author
- Pan, Weihong
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 37
- Issue
- 12
- Pages
- 1553-1561
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1972280500
- Cited by
- 1,354
- References
- 25
- Citations by year
- 2026: 33 · 2025: 53 · 2024: 85 · 2023: 64 · 2022: 63 · 2021: 100 · 2020: 89 · 2019: 77 · 2018: 66 · 2017: 76 · 2016: 82 · 2015: 65 · 2014: 78 · 2013: 62 · 2012: 53
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, blood-brain barrier, saturable transport, cerebral cortex, cerebrospinal fluid reabsorption, neurotrophic therapy
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Capillaries, Cerebrovascular Circulation, Humans, Injections, Intravenous, Iodine Radioisotopes, Kinetics, Male, Mice, Inbred ICR, Recombinant Proteins, Regression Analysis, Technetium Tc 99m Aggregated Albumin, Time Factors, Brain-Derived Neurotrophic Factor, Mice
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