The role of the rostral frontal cortex (area 10) in prospective memory: a lateral versus medial dissociation
Abstract
Using the H(2)(15)O PET method, we investigated whether previous findings of regional cerebral blood flow (rCBF) changes in the polar and superior rostral aspects of the frontal lobes (principally Brodmann's area (BA) 10) during prospective memory (PM) paradigms (i.e. those involving carrying out an intended action after a delay) can be attributed merely to the greater difficulty of such tasks over the baseline conditions typically employed. Three different tasks were administered under four conditions: baseline simple RT; attention-demanding ongoing task only; ongoing task plus a delayed intention (unpracticed); ongoing task plus delayed intention (practiced). Under prospective memory conditions, we found significant rCBF decreases in the superior medial aspects of the rostral prefrontal cortex (BA 10) relative to the baseline or ongoing task only conditions. However more lateral aspects of area 10 (plus the medio-dorsal thalamus) showed the opposite pattern, with rCBF increases in the prospective memory conditions relative to the other conditions. These patterns were broadly replicated over all three tasks. Since both the medial and lateral rostral regions showed: (a) instances where rCBF was lower during a more effortful condition (as estimated by increased RTs and error rates) than in a less effortful one; and (b) there was no correlation between rCBF and RT durations or number of errors in these regions, a simple task difficulty explanation of the rCBF changes in the ros…
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At least some of the processing supported by prefrontal structures is material-nonspecific.
“at least some of the processing supported by prefrontal structures has been shown to be material-nonspecific (Burgess et al., 2001; 2003; Gilbert et al., 2005).”
From The case for the development and use of ecologically valid measures of executive function in experimental and clinical neuropsychology (2006) · cites this paper as Burgess et al., 2003
Functional imaging experiments confirmed a role for rostral PFC, principally BA 10, in certain forms of prospective memory.
“were investigated in a series of functional imaging experiments (Burgess et al., 2001; 2003; Okuda et al., 2004) which confirmed a role for rostral PFC (principally BA 10) in certain forms of prospective memory.”
From The case for the development and use of ecologically valid measures of executive function in experimental and clinical neuropsychology (2006) · cites this paper as Burgess et al., 2003
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- Authors
- Burgess, P. W., Scott, S. K., & Frith, C. D.
- Affiliations
- University College London (GB)
- Corresponding author
- Burgess, Paul W
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 41
- Issue
- 8
- Pages
- 906-918
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2136700383
- Cited by
- 415
- References
- 4
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 20 · 2019: 12 · 2018: 22 · 2017: 18 · 2016: 21 · 2015: 23 · 2014: 17 · 2013: 34 · 2012: 23
- FWCI
- 18.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (090961)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- prospective memory, rostral prefrontal cortex, Brodmann area 10, medial prefrontal cortex, lateral prefrontal cortex, regional cerebral blood flow, task difficulty
- MeSH terms
- Adult, Attention, Brain Mapping, Cerebral Cortex, Dissociative Disorders, Humans, Functional Laterality, Male, Memory, Pattern Recognition, Visual, Photic Stimulation, Practice, Psychological, Psychomotor Performance, Radiography, Reaction Time, Regional Blood Flow, Semantics, Tomography, Emission-Computed, Prefrontal Cortex
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