Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain
Open accessAbstract
Placebo analgesia (PA) is one of the most studied placebo effects. Brain imaging studies published over the last decade, using either positron emission tomography (PET) or functional magnetic resonance imaging (fMRI), suggest that multiple brain regions may play a pivotal role in this process. However, there continues to be much debate as to which areas consistently contribute to placebo analgesia‐related networks. In the present study, we used activation likelihood estimation (ALE) meta‐analysis, a state‐of‐the‐art approach, to search for the cortical areas involved in PA in human experimental pain models. Nine fMRI studies and two PET studies investigating cerebral hemodynamic changes were included in the analysis. During expectation of analgesia, activated foci were found in the left anterior cingulate, right precentral, and lateral prefrontal cortex and in the left periaqueductal gray (PAG). During noxious stimulation, placebo‐related activations were detected in the anterior cingulate and medial and lateral prefrontal cortices, in the left inferior parietal lobule and postcentral gyrus, anterior insula, thalamus, hypothalamus, PAG, and pons; deactivations were found in the left mid‐ and posterior cingulate cortex, superior temporal and precentral gyri, in the left anterior and right posterior insula, in the claustrum and putamen, and in the right thalamus and caudate body. Our results suggest on one hand that the modulatory cortical networks involved in PA largely overlap those involved in the regulation of emotional processes, on the other that brain nociceptive networks are downregulated in parallel with behavioral analgesia. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
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The fail-safe N analysis was complemented by a jackknife analysis to cross-validate that the observed results were not driven by any single study in the dataset.
“The fail-safe N analysis was complemented by a jackknife analysis to cross-validate that the observed results were not driven by any single study in the dataset (Amanzio et al., 2013; Shao & Tu, 1995).”
From Bridging phenomenology and neural mechanisms of inner speech: ALE meta-analysis on egocentricity and spontaneity in a dual-mechanistic framework (2023) · cites this paper as Amanzio et al., 2013
The Methods section ('Jackknife Analysis'; page unavailable) says the authors used a jackknife analysis to test whether activations were driven by a small subset of studies. The Results section ('Reliability of the Identified Clusters: Jackknife Analysis'; page unavailable) reports that no identified cluster was driven by a single paper. Our copy does not say that this analysis complemented a fail-safe N analysis. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAn inert treatment could function through three interrelated processes to produce placebo and nocebo effects.
“Theoretically, an inert treatment could function through three interrelated processes to produce placebo and nocebo effects (Amanzio et al., 2013; Kong et al., 2007).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Amanzio et al., 2013
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“Theoretically, an inert treatment could function through three interrelated processes to produce placebo and nocebo effects (Amanzio et al., 2013; Kong et al., 2007).”
BackgroundMethodPlacebo improves pleasure and pain through opposite modulation of sensory processing
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“The fail-safe N analysis was complemented by a jackknife analysis to cross-validate that the observed results were not driven by any single study in the dataset (Amanzio et al., 2013; Shao and Tu, 1995).”
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- Authors
- Amanzio, M., Benedetti, F., Porro, C. A., Palermo, S., & Cauda, F.
- Affiliations
- University of Turin (IT)
- University of Modena and Reggio Emilia (IT)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2011-11-29
- Volume
- 34
- Issue
- 3
- Pages
- 738-752
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6870130
- OpenAlex
- W1985701424
- Cited by
- 202
- References
- 64
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 15 · 2023: 7 · 2022: 10 · 2021: 20 · 2020: 14 · 2019: 11 · 2018: 19 · 2017: 22 · 2016: 17 · 2015: 20 · 2014: 17 · 2013: 17 · 2012: 3
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- Volkswagen Foundation
- Regione Piemonte
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- placebo analgesia, placebo effect, experimental pain, brain correlates, anterior cingulate cortex, prefrontal cortex, periaqueductal gray, brain deactivation, emotion regulation, thalamus, insula
- MeSH terms
- Analgesia, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Pain, Physical Stimulation, Reproducibility of Results, Placebo Effect, Likelihood Functions, Databases, Factual, Positron-Emission Tomography, Pain Management
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