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Cited by 100Hemispheric Asymmetry in NeuroscienceMotor Control and AdaptationNeural and Behavioral Psychology Studies

The left hemisphere and the selection of learned actions

Rushworth, Matthew F.S., Nixon, Philip D., Wade, Derick T., Renowden, Shelley, Passingham, Richard E.·1998·Neuropsychologia
DOI 10.1016/s0028-3932(97)00101-2
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Abstract

The left hemisphere's dominance for movement is well known. The basis of its dominance is less clear. We have tested 16 left hemisphere (LH) patients, 17 right hemisphere (RH) patients and 12 neurologically normal controls on a battery of five tasks. The tasks were based on animal lesion and recording studies, and human imaging and magnetic stimulation studies that identified two distributed systems that are important for the selection of motor responses and object-oriented responses. The LH patients were impaired on three response selection tasks: learning to select between joystick movement responses instructed by visual cues; learning to select between analogous object-oriented responses instructed by visual cues; learning to select movements in a sequence. Although we replicated the finding that LH damage impairs sequencing, some of the impaired tasks had no sequencing element. We therefore argue that the LH deficits are best explained as an impairment of response selection. This was confirmed by showing that LH subjects were unimpaired on a more demanding task-object discrimination learning-which imposed a greater memory load but had no response selection element. Moreover, the LH deficits could not be attributed to disorganization of movement kinematics. The lesions of the impaired LH group were widespread but always included the distributed systems known to be important for response selection-the dorsolateral frontal and parietal cortices, striatum, thalamus and white matter fascicles.

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Authors
Rushworth, M. F. S., Nixon, P. D., Wade, D. T., Renowden, S., & Passingham, R. E.
Affiliations
University of Oxford (GB)
Corresponding author
Rushworth, Matthew F.S.
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
1998-01
Volume
36
Issue
1
Pages
11-24
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/s0028-3932(97)00101-2
OpenAlex
W2073117701
Cited by
100
References
87
Citations by year
2024: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 5
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
left hemisphere dominance, hemispheric lateralization, response selection, movement sequencing, visuomotor learning, dorsolateral prefrontal cortex, parietal cortex, striatum, thalamus, white matter tracts, hemispatial neglect, movement kinematics
MeSH terms
Adult, Aged, Apraxias, Brain, Cerebral Cortex, Corpus Striatum, Female, Humans, Functional Laterality, Male, Middle Aged, Motor Skills, Reinforcement, Psychology, Thalamus

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