The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Serum allopregnanolone in women with postpartum “blues”
Abstract
Objective To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues." Methods Forty primiparous, healthy, married women (24-39 years of age; at least 13 years of education) who delivered healthy neonates in the Department of Obstetrics at the University of Pavia entered the present study. Blood samples were drawn at 8:30 AM on postpartum day 3 for measurements of serum allopregnanolone, progesterone, cortisol, prolactin, and estradiol. On the same day, every woman was interviewed using the Hamilton Rating Scale for Depression for psychometric testing and completed a self-administered version of the Stein Questionnaire for symptoms of the "blues." Results Eighteen of 40 women (45%) experienced maternity "blues" (12 who delivered vaginally and six who delivered by cesarean). Serum allopregnanolone levels were significantly lower in those women experiencing postpartum "blues" with respect to euthymic women (1.1 +/- 0.4 versus 2.3 +/- 1.0 nmol/L; P .058). Allopregnanolone and progesterone levels correlated significantly in euthymic women (r =.648; P =.001) but not in those with postpartum "blues" (r =.317; P =.199). There was a significant negative correlation between the Hamilton score and levels of serum allopregnanolone (r = -.62; P =.001) and progesterone (r = -.36; P =.024). Conclusion Serum allopregnanolone levels were detectable postpartum and were significantly decreased in women with maternity "blues."
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“One potential factor affecting GABAergic signaling and PPD development are dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid (NAS) GABAA receptor (GABAAR)–positive allosteric modulator (PAM).29,30,31,32”
From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [31]
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Cites
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410
Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,413
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,089
Maternity blues and major endocrine changes: Cardiff puerperal mood and hormone study II
Harris, B. L., Lovett, L. M., Newcombe, R. G., Read, G. F., Walker, R., & Riad-Fahmy, D. (1994) · BMJ · doi:10.1136/bmj.308.6934.949 · Cited by 486
Psychiatric Disorder in Pregnancy and the First Postnatal Year
Watson, J. P., Elliott, S. A., Rugg, A. J., & Brough, D. I. (1984) · The British Journal of Psychiatry · doi:10.1192/bjp.144.5.453 · Cited by 477
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain
Mellon, S. H., & Deschepper, C. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91332-m · Cited by 398
Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences
Genazzani, A. R., Petraglia, F., Bernardi, F., Casarosa, E., Salvestroni, C., Tonetti, A., Nappi, R. E., Luisi, S. V., Palumbo, M. A., Purdy, R. H., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4905 · Cited by 392
Self-citationBitran, D., Shiekh, M., & McLeod, M. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00744.x · Cited by 388
Prospective Study of Postpartum Blues: Biologic and Psychosocial Factors
O'Hara, M. W. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810330025004 · Cited by 345
Röbel, P., & Baulieu, É.-É. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)90114-7 · Cited by 312
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Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-101414-020426 · Cited by 749
Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.
Kanes, S., Colquhoun, H., Gunduz-Bruce, H., Raines, S., Arnold, R., Schacterle, A., Doherty, J., Epperson, C. N., Deligiannidis, K. M., Riesenberg, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31264-3 · Cited by 479
Sex differences in depression: Insights from clinical and preclinical studies
Eid, R. S., Gobinath, A. R., & Galea, L. A. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.006 · Cited by 486
Pathophysiological mechanisms implicated in postpartum depression
Payne, J. L., & Maguire, J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.12.001 · Cited by 459
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407
Metadata
- Authors
- Nappi, R.
- Affiliations
- University of Siena (IT)
- ORCID
- Nappi, R
- Venue
- Obstetrics & Gynecology
- Published
- 2001-01
- Volume
- 97
- Issue
- 1
- Pages
- 77-80
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2004123621
- Cited by
- 166
- References
- 28
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 5 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 3 · 2013: 12 · 2012: 4
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- allopregnanolone, postpartum blues, postpartum depression, progesterone, serum steroid hormones, primiparous women, cortisol, prolactin, estradiol, Hamilton Depression Rating Scale
- MeSH terms
- Adult, Female, Humans, Pregnanolone, Progesterone, Prospective Studies, Biomarkers, Depression, Postpartum
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