The expectant brain: adapting for motherhood

Brunton, Paula J.; Russell, John A.

doi:10.1038/nrn2280

Cited by 407Maternal Mental Health During Pregnancy and PostpartumNeuroendocrine regulation and behaviorPregnancy-related medical research

The expectant brain: adapting for motherhood

Brunton, Paula J., Russell, John A.·2008·Nature Reviews Neuroscience

DOI 10.1038/nrn2280

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Abstract

A successful pregnancy requires multiple adaptations of the mother's physiology to optimize fetal growth and development, to protect the fetus from adverse programming, to provide impetus for timely parturition and to ensure that adequate maternal care is provided after parturition. Many of these adaptations are organized by the mother's brain, predominantly through changes in neuroendocrine systems, and these changes are primarily driven by the hormones of pregnancy. By contrast, adaptations in the mother's brain during lactation are maintained by external stimuli from the young. The changes in pregnancy are not necessarily innocuous: they may predispose the mother to post-partum mood disorders.

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Authors: Brunton, P. J., & Russell, J. A.
Affiliations: University of Edinburgh (GB)
Corresponding author: Russell, John A.
ORCID: Brunton, Paula J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2008-01
Volume: 9
Issue: 1
Pages: 11-25
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2280
OpenAlex: W2053307562
Cited by: 407
References: 186
Citations by year: 2026: 11 · 2025: 17 · 2024: 20 · 2023: 32 · 2022: 17 · 2021: 27 · 2020: 30 · 2019: 28 · 2018: 23 · 2017: 17 · 2016: 28 · 2015: 33 · 2014: 29 · 2013: 15 · 2012: 15
FWCI: 2.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords: pregnancy, lactation, allopregnanolone, opioids, postpartum mood disorders, neuroendocrine regulation, pregnancy hormones, childbirth, maternal care, fetal programming
MeSH terms: Adaptation, Physiological, Animals, Brain, Female, Hormones, Humans, Lactation, Maternal Behavior, Neurosecretory Systems, Pregnancy, Puerperal Disorders, Mood Disorders, Fetal Development

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The expectant brain: adapting for motherhood

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