Chiral Drugs. An Overview

Role of Pharmacokinetics and Metabolism in Drug Discovery and Development

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The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

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Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls

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Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: An overview

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Stereochemistry in Drug Action

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The importance of stereoselective determination of drugs in the clinical laboratory

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Mechanism of action of barbiturates.

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Bioanalysis of drugs by liquid-phase microextraction coupled to separation techniques.

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The specification of asymmetric configuration in organic chemistry

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Chiral Separations By Liquid Chromatography And Related Technologies

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Screening approach for chiral separation of pharmaceuticals

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Pharmacology of chiral compounds: 2-arylpropionic acid derivatives.

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The Influence of β-Adrenoceptor Blocking Agents on Plasma Thyroxine and Triiodothyronine

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Chirality: a blueprint for the future

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Thalidomide: Tragic Past and Promising Future

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Clinical eftects and pharmacokinetics of racemic methadone and its optical isomers

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Chirality in Drug Design and Development

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Enantioselective inhibition of TNF-? release by thalidomide and thalidomide-analogues

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Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

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Resolution of chiral drugs by liquid chromatography based upon diastereomer formation with chiral derivatization reagents.

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Chiral separations : methods and protocols

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Preparative chiral chromatographic resolution of enantiomers in drug discovery.

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Screening approach for chiral separation of pharmaceuticals IV. Polar organic solvent chromatography.

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Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations.

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Electrophysiologic Effects of Dextro‐ and Levo‐Verapamil on Sinus Node and AV Node Function in Humans

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Impact of Stereoselectivity on the Pharmacokinetics and Pharmacodynamics of Antiarrhythmic Drugs

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Coronary Vasodilator and Cardiac Effects of Optical Isomers of Verapamil in the Dog

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Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats.

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New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica.

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THYROXINE AND TRIIODOTHYRONINE LEVELS IN HYPERTHYROID PATIENTS DURING TREATMENT WITH PROPRANOLOL

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Solid-phase extraction of methadone enantiomers and benzodiazepines in biological fluids by two polymeric cartridges for liquid chromatographic analysis

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Benzodiazepine receptors in the central nervous system.

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Levalbuterol Nebulizer Solution: Is It Worth Five Times the Cost of Albuterol?

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Racemic (R,S)‐propranolol versus half‐dosed optically pure (S)‐propranolol in humans at steady state: Hemodynamic effects, plasma concentrations, and influence on thyroid hormone levels

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Chirality Clinical Pharmacokinetic and Pharmacodynamic Considerations

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Whats New in Chromatographic Enantioseparations

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Three-dimensional pharmacology, a subject ranging from ignorance to overstatements.

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Enantiomeric composition of abused amine drugs: chromatographic methods of analysis and data interpretation

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Enantioselective high-performance liquid chromatography determination of methadone enantiomers and its major metabolite in human biological fluids using a new derivatized cyclodextrin-bonded phase.

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High-performance liquid chromatographic determination of (S)- and (R)-propranolol in human plasma and urine with a chiral beta-cyclodextrin bonded phase.

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Biomedical aspects of chiral molecules

Patočka, J., & Dvořák, A. (2004) · doi:10.32725/jab.2004.011 · Cited by 37

Studies on the antihypertensive action of the optical isomers of propranolol in man

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Inside the isomers: the tale of chiral switches

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Separation of oxazepam, lorazepam, and temazepam enantiomers by HPLC on a derivatized cyclodextrin-bonded phase: application to the determination of oxazepam in plasma.

Pham-Huy, C., Villain-Pautet, G., He, H., et al. (2002) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00123-9 · Cited by 35 · see citing works

Simultaneous enantioselective determination of amphetamine and congeners in hair specimens by negative chemical ionization gas chromatography-mass spectrometry.

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Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism.

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Rapid determination of methadone and its major metabolite in biological fluids by gas-liquid chromatography with thermionic detection for maintenance treatment of opiate addicts.

Chikhi-Chorfi, N., Pham-Huy, C., Galons, H., et al. (1998) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00375-2 · Cited by 34 · see citing works

A CONVENIENT ASYMMETRIC SYNTHESIS OF THALIDOMIDE

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Simulated moving bed chromatography with supercritical fluids for the resolution of bi-naphthol enantiomers and phytol isomers.

Johannsen, M., Peper, S., & Depta, A. (2002) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00132-x · Cited by 30 · see citing works

Single-isomer levalbuterol: A review of the acute data

Nowak, R. (2003) · Current Allergy and Asthma Reports · doi:10.1007/s11882-003-0031-8 · Cited by 29 · see citing works

Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of tetrahydropalmatine enantiomers in dogs

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Chiral separation of salbutamol and bupivacaine by capillary electrophoresis using dual neutral cyclodextrins as selectors and its application to pharmaceutical preparations and rat blood samples assay.

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Stereoselectivity of Antibodies for the Bioanalysis of Chiral Drugs

Got, P., & Scherrmann, J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012161814494 · Cited by 26 · see citing works

Chiral chromatographic separation of β-blockers

Agrawal, Y., & Patel, R. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.03.003 · Cited by 24 · see citing works

Enantioselective analytical methods in pharmacokinetics with specific reference to genetic polymorphic metabolism.

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Thalidomide enantiomers: Determination in biological samples by HPLC and vancomycin-CSP

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An expeditious synthesis of cyclic imides

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Effect of Temperature on Enantiomer Separation of Oxzepam and Lorazepam by High-Performance Liquid Chromatography on a -Cyclodextrin Derivatized Bonded Chiral Stationary Phase

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Microassay of propranolol enantiomers and conjugates in human plasma and urine by high-performance liquid chromatography after chiral derivatization for pharmacokinetic study

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Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography.

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In vitro and in vivo immunosuppressive potential of thalidomide and its derivative, N-hydroxythalidomide, alone and in combination with cyclosporin A.

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Side effects and toxic reactions of chiral drugs: a clinical perspective.

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Chiral Separation Principles

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Selective antibodies to propranolol enantiomers produced from a new conjugate.

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STEREOCHEMICAL TERMS AND CONCEPTS: AN OVERVIEW*

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Selective antibodies to methadone enantiomers: synthesis of (R)- and (R,S)-methadone conjugates and determination by an immunoenzymatic method in human serum.

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ASYMMETRIC CATALYSIS WINS: Chemistry Nobel honors Knowles, Noyori, Sharpless for chiral syntheses

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Pharmacokinetic profiles of methadone enantiomers and its major metabolite in serum, saliva and urine of treated patients

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Enzymic Synthesis and Resolution of Enantiomerically Pure Compounds

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Free Radicals, Antioxidants in Disease and Health

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Pharmaceuticals of Emerging Concern in Aquatic Systems: Chemistry, Occurrence, Effects, and Removal Methods

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Adsorptive separation on metal–organic frameworks in the liquid phase

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Carbon Nanotubes: Applications in Pharmacy and Medicine

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Pharmacologically active compounds in the environment and their chirality

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Applications of bacterial cellulose in food, cosmetics and drug delivery

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The development of ruthenium( ii ) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

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Chiral Graphene Quantum Dots

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Geometric deep learning on molecular representations

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Nanophotonic Approaches for Chirality Sensing

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Chiral AIEgens – Chiral recognition, CPL materials and other chiral applications

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Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

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Chiral carbon dots: synthesis, optical properties, and emerging applications

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Global risk of pharmaceutical contamination from highly populated developing countries

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Lateral chirality-sorting optical forces

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Chirality of New Drug Approvals (2013–2022): Trends and Perspectives

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Enantiospecific Optical Enhancement of Chiral Sensing and Separation with Dielectric Metasurfaces

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The Role of Plasmon-Generated Near Fields for Enhanced Circular Dichroism Spectroscopy

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Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers

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Enhanced Chiral Sensing with Dielectric Nanoresonators

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Applications of OR/ECD/VCD to the structure elucidation of natural products

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D‐Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection

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Chiral Supraparticles for Controllable Nanomedicine

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Metallogels: Availability, Applicability, and Advanceability

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Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

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High Quality Factor Dielectric Metasurfaces for Ultraviolet Circular Dichroism Spectroscopy

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Chiral Separations

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Self-assembly of AIEgens

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Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers

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Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

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