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Animal Models of Nociception
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Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
D'AMOUR, F. E., & Smith, D. L. (1941) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03823-6 · Cited by 3,238
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,534
The formalin test: an evaluation of the method
Tjølsen, A., Berge, O., Hunskaar, S., Rosland, J. H., & Hole, K. (1992) · Pain · doi:10.1016/0304-3959(92)90003-t · Cited by 2,434
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
Hunskaar, S., & Hole, K. (1987) · Pain · doi:10.1016/0304-3959(87)90088-1 · Cited by 2,191
ACETIC ACID FOR ANALGESIC SCREENING
KOSTER, R., Anderson, W. N., & de Beer, E. J. (1959) · Medical Entomology and Zoology · Cited by 2,132
Habituation: a dual-process theory.
Groves, P. M., & Thompson, R. F. (1970) · Psychology Review · doi:10.1037/h0029810 · Cited by 2,110
Vanilloid (Capsaicin) Receptors and Mechanisms
SZALLASI, A., & Blumberg, P. M. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01403-0 · Cited by 1,903
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.
Holzer, P. D. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06664-5 · Cited by 1,784
SYNTHETIC ANALGESICS. II. DITHIENYLBUTENYL- AND DITHIENYLBUTYLAMINES
Eddy, N. B., & Leimbach, D. G. (1953) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)05180-8 · Cited by 1,765
New Developments in Electromyography and Clinical Neurophysiology.
(1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320078016 · Cited by 1,623
A method for measurement of analgesic activity on inflamed tissue.
Randall, L. O., & Selitto, J. J. (1957) · PubMed · Cited by 1,568
Flexion‐reflex of the limb, crossed extension‐reflex, and reflex stepping and standing
Sherrington, C. (1910) · The Journal of Physiology · doi:10.1113/jphysiol.1910.sp001362 · Cited by 1,336
THE ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN THE MOUSE
COLLIER, H. O. J., Dinneen, L. C., Johnson, C. A., & Schneider, C. (1968) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1968.tb00973.x · Cited by 1,228
Raffa, R. B., Friderichs, E., Reimann, W., Shank, R. P., Codd, E. E., & Vaught, J. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11227-5 · Cited by 1,163
Characterization of a rat model of incisional pain
Brennan, T. J., Vandermeulen, E., & Gebhart, G. F. (1996) · Pain · doi:10.1016/0304-3959(95)01441-1 · Cited by 1,101
Chapman, C. R., Casey, K. L., Dubner, R. A., Foley, K. M., Gracely, R. H., & Reading, A. E. (1985) · Pain · doi:10.1016/0304-3959(85)90145-9 · Cited by 1,095
THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)
Woolfe, G., & MacDonald, A. (1944) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09094-9 · Cited by 1,053
Morton, D. B., & Griffiths, P. (1985) · Veterinary Record · doi:10.1136/vr.116.16.431 · Cited by 1,039
Advances in Pain Research and Therapy
Carron, H. (1985) · Anesthesiology · doi:10.1097/00000542-198501000-00033 · Cited by 966
Modified formalin test: characteristic biphasic pain response
Shibata, M., Ohkubo, T., Takahashi, H., & Inoki, R. (1989) · Pain · doi:10.1016/0304-3959(89)90222-4 · Cited by 955
The Integrative Action of the Nervous System.
Freeman, F. N., & SHERRINGTON, S. C. (1907) · The Journal of Philosophy Psychology and Scientific Methods · doi:10.2307/2010953 · Cited by 906
Functional characteristics of the midbrain periaqueductal gray.
Behbehani, M. M. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00009-k · Cited by 879
Formalin test in mice, a useful technique for evaluating mild analgesics
Hunskaar, S., Fasmer, O. B., & Hole, K. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90116-5 · Cited by 825
Organization of endogenous opiate and nonopiate pain control systems
Watkins, L. R., & Mayer, D. J. (1982) · Science · doi:10.1126/science.6281891 · Cited by 791
Method for quantitative estimation of thermal thresholds in patients.
Fruhstorfer, H., Lindblom, U., & Schmidt, W. C. (1976) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.39.11.1071 · Cited by 785
Opioid and Nonopioid Mechanisms of Stress Analgesia
Lewis, J. W., Cannon, J. T., & Liebeskind, J. C. (1980) · Science · doi:10.1126/science.7367889 · Cited by 747
Ness, T. J., & Gebhart, G. F. (1988) · Brain Research · doi:10.1016/0006-8993(88)91555-7 · Cited by 658
Malmberg, A. B., & Yaksh, T. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10314-5 · Cited by 652
Visceral pain: a review of experimental studies
Ness, T. J., & Gebhart, G. F. (1990) · Pain · doi:10.1016/0304-3959(90)90021-5 · Cited by 605
Pain “relief” by frontal cingulumotomy
Foltz, E. L., & White, L. E. (1962) · Journal of Neurosurgery · doi:10.3171/jns.1962.19.2.0089 · Cited by 588
The formalin test: scoring properties of the first and second phases of the pain response in rats
Abbott, F. V., Franklin, K. B. J., & Westbrook, R. F. (1995) · Pain · doi:10.1016/0304-3959(94)00095-v · Cited by 587
Comparative study of perceived pain and nociceptive flexion reflex in man
Willer, J. C. (1977) · Pain · doi:10.1016/0304-3959(77)90036-7 · Cited by 554
Reflex Activity of the Spinal Cord.
(1932) · JAMA · doi:10.1001/jama.1932.02740720069041 · Cited by 551
Ultrasonic Communication by Animals
Sales, G., & Pye, D. (1974) · Springer eBooks · doi:10.1007/978-94-011-6901-1 · Cited by 539
Sensory innervation of the viscera: peripheral basis of visceral pain
Cerveró, F. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.95 · Cited by 526
The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat
Fields, H. L., Bry, J., Hentall, I. D., & Zorman, G. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-12-02545.1983 · Cited by 518
Tension receptors in the stomach and the urinary bladder
Iggo, A. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005327 · Cited by 515
Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy
Attal, N., Jazat, F., Kayser, V., & Guilbaud, G. (1990) · Pain · doi:10.1016/0304-3959(90)90022-6 · Cited by 503
A Method for Evaluating both Non-Narcotic and Narcotic Analgesics
Siegmund, E. A., Cadmus, R., & Lu, G. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-95-23345 · Cited by 495
Synaptic actions in motoneurones by afferents in which may evoke the flexion reflex
Eccles, R. M., & Lunberg, A. (1959) · ARCHIVES ITALIENNES DE BIOLOGIE · doi:10.4449/aib.v97i3.3542 · Cited by 492
The measurement of pain; prototype for the quantitative study of subjective responses.
Beecher, H. K. (1957) · PubMed · Cited by 490
Steen, K. H., Reeh, P. W., Anton, F., & Handwerker, H. O. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-01-00086.1992 · Cited by 487
Puig, S., & Sorkin, L. S. (1996) · Pain · doi:10.1016/0304-3959(95)00121-2 · Cited by 473
Evaluation of Drug Activities: Pharmacometrics
Després, L., & Bacharach, A. L. (1964) · Cited by 463
LaMotte, R. H., & Campbell, J. N. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.509 · Cited by 456
RELATIONSHIP OF SIGNIFICANCE OF WOUND TO PAIN EXPERIENCED
Beecher, H. K. (1956) · JAMA · doi:10.1001/jama.1956.02970170005002 · Cited by 454
Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment
Babbini, M., & Davis, W. M. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06866.x · Cited by 443
Treede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020619 · Cited by 440
Iadarola, M. J., Brady, L. S., Draisci, G., & Dubner, R. A. (1988) · Pain · doi:10.1016/0304-3959(88)90141-8 · Cited by 437
The genetic mediation of individual differences in sensitivity to pain and its inhibition
Mogil, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7744 · Cited by 433
Brain Stem Control of Spinal Mechanisms
Chandler, C., Hewitt, J. R., Miller, S. N., & Tan, N. (1982) · Cited by 428
Hayes, R. L., Bennett, G. J., Newlon, P. G., & Mayer, D. J. (1978) · Brain Research · doi:10.1016/0006-8993(78)90306-2 · Cited by 413
Interactions between cardiovascular and pain regulatory systems
Randich, A., & Maixner, W. D. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90057-5 · Cited by 413
BEHAVIORAL EFFECTS OF SOME PSYCHOPHARMACOLOGICAL AGENTS
Cook, L., & Weidley, E. F. (1957) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1957.tb40763.x · Cited by 412
Bowsher, D. R. (1978) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(78)90254-x · Cited by 404
The formalin test in mice: effect of formalin concentration
Rosland, J. H., Tjølsen, A., Maehle, B. O., & Hole, K. (1990) · Pain · doi:10.1016/0304-3959(90)91167-h · Cited by 399
Yeomans, D. C., Pirec, V., & Proudfit, H. K. (1996) · Pain · doi:10.1016/s0304-3959(96)03176-4 · Cited by 395
Stress-induced analgesia: adaptive pain suppression
Amit, Z., & Galina, Z. H. (1986) · Physiological Reviews · doi:10.1152/physrev.1986.66.4.1091 · Cited by 382
Ochoa, J., & Mair, W. G. P. (1969) · Acta Neuropathologica · doi:10.1007/bf00690642 · Cited by 373
Bateson, P. (1991) · Animal Behaviour · doi:10.1016/s0003-3472(05)80127-7 · Cited by 372
Standardization of the rat paw formalin test for the evaluation of analgesics
Wheeler-Aceto, H., & Cowan, A. (1991) · Psychopharmacology · doi:10.1007/bf02244551 · Cited by 367
Hardy, J. D., Wolff, H. G., & Goodell, H. (1940) · Journal of Clinical Investigation · doi:10.1172/jci101168 · Cited by 361
Spinal sensorimotor systems and their supraspinal control
Schomburg, E. D. (1990) · Neuroscience Research · doi:10.1016/0168-0102(90)90008-3 · Cited by 355
NEURON PATTERNS CONTROLLING TRANSMISSION OF IPSILATERAL HIND LIMB REFLEXES IN CAT
Lloyd, D. P. C. (1943) · Journal of Neurophysiology · doi:10.1152/jn.1943.6.4.293 · Cited by 355
Psychophysiology of experimentally induced pain
Handwerker, H. O., & Kobal, G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.3.639 · Cited by 352
The rat paw formalin test: comparison of noxious agents
Wheeler-Aceto, H., Porreca, F., & Cowan, A. (1990) · Pain · doi:10.1016/0304-3959(90)90073-m · Cited by 352
Hendershot, L. C., & Forsaith, J. (1959) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12981-9 · Cited by 343
Irwin, S., Bennett, D. R., Hendershot, L. C., Seevers, M. H., & Houde, R. W. (1951) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)07642-6 · Cited by 338
Relationship between pain and tissue damage due to thermal radiation
Stoll, A. M., & Greene, L. C. (1959) · Journal of Applied Physiology · doi:10.1152/jappl.1959.14.3.373 · Cited by 328
Torebj�rk, H. E., & Hallin, R. G. (1973) · Experimental Brain Research · doi:10.1007/bf00233334 · Cited by 322
Supraspinal control of interneurones mediating spinal reflexes
Eccles, R. M., & Lundberg, A. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006262 · Cited by 318
Sensory mechanisms in mammalian teeth and their supporting structures.
Anderson, D. J., Hannam, A. G., & Mathews, B. E. (1970) · Physiological Reviews · doi:10.1152/physrev.1970.50.2.171 · Cited by 314
A limited arthritic model for chronic pain studies in the rat
Butler, S. H., Godefroy, F., Besson, J., & Weil-Fugazza, J. (1992) · Pain · doi:10.1016/0304-3959(92)90133-v · Cited by 311
Observations on the scratch‐reflex in the spinal dog
Sherrington, C. (1906) · The Journal of Physiology · doi:10.1113/jphysiol.1906.sp001139 · Cited by 306
Vagal afferent modulation of nociception
Randich, A., & Gebhart, G. F. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90009-b · Cited by 298
Bandler, R. J., & Keay, K. A. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61871-3 · Cited by 294
Woolf, C. J., & Wiesenfeld‐Hallin, Z. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90195-3 · Cited by 294
Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure.
O'Callaghan, J. P., & Holtzman, S. G. (1975) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30089-3 · Cited by 278
Modifiability of spinal synapses.
Mendell, L. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.260 · Cited by 276
Yeomans, D. C., & Proudfit, H. K. (1996) · Pain · doi:10.1016/s0304-3959(96)03177-6 · Cited by 276
Conduction failure in myelinated and non‐myelinated axons at low temperatures
Franz, D. N., & Iggo, A. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008656 · Cited by 270
Paintal, A. S. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005207 · Cited by 266
The Lower Brainstem and Bodily Homeostasis
Loewy, A. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01234-x · Cited by 262
A new technique for the investigation of some analgesic drugs on a reflexive behavior in the rat
Evans, W. Ο. (1961) · Psychopharmacology · doi:10.1007/bf00404119 · Cited by 257
Holmqvist, B., & Lundberg, A. (1961) · PubMed · Cited by 251
An Improved Method for Assessing Mechanical Allodynia in the Rat
Ren, K. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00136-5 · Cited by 249
Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli
Dirig, D. M., Salami, A., Rathbun, M. L., Ozaki, G. T., & Yaksh, T. L. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00097-6 · Cited by 248
Capsaicin: actions on nociceptive C-fibres and therapeutic potential
Lynn, B. (1990) · Pain · doi:10.1016/0304-3959(90)91110-5 · Cited by 242
The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord
Sakurada, T., Katsumata, K., Tan–No, K., Sakurada, S., & Kisara, K. (1992) · Neuropharmacology · doi:10.1016/0028-3908(92)90057-v · Cited by 238
Sewell, R. D. E. (1976) · Neuropharmacology · doi:10.1016/0028-3908(76)90037-x · Cited by 236
The formalin test: a validation of the weighted-scores method of behavioural pain rating
Coderre, T. J., Fundytus, M. E., McKenna, J. E., Dalal, S., & Melzack, R. (1993) · Pain · doi:10.1016/0304-3959(93)90098-a · Cited by 234
The bee venom test: a new tonic-pain test
Lariviere, W. R., & Melzack, R. (1996) · Pain · doi:10.1016/0304-3959(96)03075-8 · Cited by 232
THE TAIL OF THE RAT, IN TEMPERATURE REGULATION AND ACCLIMATIZATION
Rand, R. P., Burton, A. C., & Ing, T. (1965) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y65-025 · Cited by 232
Presynaptic hyperpolarization: a role for fine afferent fibres
Mendell, L. M., & Wall, P. D. (1964) · The Journal of Physiology · doi:10.1113/jphysiol.1964.sp007417 · Cited by 230
Selective activation of small motor axons by quasitrapezoidal current pulses
Fang, Z.-P., & Mortimer, J. T. (1991) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.76383 · Cited by 222
A psychophysical analysis of morphine analgesia
Price, D. D., von der Gruen, A., Miller, J. W., Rafii, A., & Price, C. (1985) · Pain · doi:10.1016/0304-3959(85)90026-0 · Cited by 219
Perkins, M., Campbell, E., & Dray, A. (1993) · Pain · doi:10.1016/0304-3959(93)90080-9 · Cited by 219
The Midbrain periaqueductal gray matter : functional, anatomical, and neurochemical organization
Depaulis, A., & Bandler, R. J. (1991) · Plenum Press eBooks · Cited by 216
Do insects feel pain? — A biological view
Eisemann, C. H., Jorgensen, W. K., Merritt, D. J., Rice, M. J., Cribb, B. W., Webb, P. D., & Zalucki, M. P. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01963580 · Cited by 216
Functional organization of the nociceptive withdrawal reflexes
Schouenborg, J., & Kalliom�ki, J. (1990) · Experimental Brain Research · doi:10.1007/bf00232194 · Cited by 216
Lovick, T. A. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90036-r · Cited by 215
Jensen, T. S., & Yaksh, T. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)90662-1 · Cited by 214
Vertebral Muscles of the Back and Tail of the Albino Rat (Rattus norvegicus albinus); pp. 1–23
Brink, E. E., & Pfaff, D. W. (2008) · Brain Behavior and Evolution · doi:10.1159/000121788 · Cited by 213
Methodological refinements to the mouse paw formalin test
Murray, C. W., Porreca, F., & Cowan, A. (1988) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(88)90078-2 · Cited by 210
Pharmacological methods in the control of inflammation
CHANG, J. Y., & Lewis, A. J. (1989) · A.R. Liss eBooks · Cited by 209
Jasmin, L., Kohan, L. R., Franssen, M., Janni, G., & Goff, J. R. (1998) · Pain · doi:10.1016/s0304-3959(98)00017-7 · Cited by 209
A pseudaffective reflex and its spinal path
Woodworth, R. S., & Sherrington, C. (1904) · Journal of Physiology · doi:10.1113/jphysiol.1904.sp001034 · Cited by 208
Gilchrist, H. D., Allard, B. L., & Simone, D. A. (1996) · Pain · doi:10.1016/0304-3959(96)03104-1 · Cited by 207
Walters, E. T. (1994) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60307-4 · Cited by 206
Yarnitsky, D., & Ochoa, J. L. (1990) · Pain · doi:10.1016/0304-3959(90)91055-n · Cited by 205
Response characteristics of cutaneous warm receptors in the monkey
Duclaux, R., & Sr. Kenshalo, D. R. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.1.1 · Cited by 204
Schouenborg, J., & Sjölund, B. H. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.50.5.1108 · Cited by 201
Winter, J., Bevan, S., & Campbell, E. A. (1995) · British Journal of Anaesthesia · doi:10.1093/bja/75.2.157 · Cited by 200
Maves, T. J., & Gebhart, G. F. (1992) · Anesthesiology · doi:10.1097/00000542-199201000-00014 · Cited by 198
Evidence that adjuvant arthritis in the rat is associated with chronic pain
Colpaert, F. C. (1987) · Pain · doi:10.1016/0304-3959(87)90117-5 · Cited by 196
Application of the formalin test to the study of orofacial pain in the rat
Clavelou, P., Pajot, J., Dallel, R., & Raboisson, P. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90125-0 · Cited by 196
Midbrain Periaqueductal Gray Control of Defensive Behavior in the Cat and the Rat
Bandler, R. J., & Depaulis, A. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3302-3_11 · Cited by 193
Kugelberg, E., Eklund, K., & Grimby, L. (1960) · Brain · doi:10.1093/brain/83.3.394 · Cited by 190
The Opioid System and Temperature Regulation
Adler, M. W., Geller, E. B., Rosow, C. E., & Cochin, J. (1988) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.28.040188.002241 · Cited by 189
A modified hot-plate test sensitivie to mild analgesics
Hunskaar, S., Berge, O., & Hole, K. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90088-4 · Cited by 188
Bars, D. L., Guilbaud, G., Jurna, I., & Besson, J. (1976) · Brain Research · doi:10.1016/0006-8993(76)90370-x · Cited by 188
Formalin induces biphasic activity in C-fibers in the rat
McCall, W. D., Tanner, K. D., & Levine, J. D. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12552-0 · Cited by 185
Assessing pain threshold in the rat: Changes with estrus and time of day
Martı́nez–Gómez, M., Cruz, Y., Salas, M., Hudson, R., & Pacheco, P. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90040-x · Cited by 185
Antinociceptive effect of centrally administered caerulein and cholecystokinin octapeptide (CCK-8)
Jurna, I., & ZETLER, G. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90233-8 · Cited by 184
Pain measurement in man — Neurophysiological correlates of pain
Buruma, O. J. S. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90194-7 · Cited by 180
Kayser, V., & Guilbaud, G. (1987) · Pain · doi:10.1016/0304-3959(87)91064-5 · Cited by 180
The permanent anatomical effects of neonatal capsaicin on somatosensory nerves.
Jw, S. (1980) · PubMed · Cited by 180
REFLEXES TO FOOT MUSCLES IN THE CAT.
Engberg, I. (1964) · PubMed · Cited by 180
Evolutionary and comparative aspects of nociception
Kavaliers, M. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90030-5 · Cited by 179
New hot plate tests to quantify antinociceptive and narcotic antagonist activities
Ankier, S. I. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90195-2 · Cited by 177
SENSORY EFFECTS IN MAN OF LESIONS OF THE POSTERIOR COLUMNS AND OF SOME OTHER AFFERENT PATHWAYS
Nathan, P. W., SMITH, M. C., & Cook, A. W. (1986) · Brain · doi:10.1093/brain/109.5.1003 · Cited by 176
Fine afferent nerve fibers and pain
Bennett, G. J. (1988) · Pain · doi:10.1016/0304-3959(88)90172-8 · Cited by 176
Ethical standards for investigations of experimental pain in animals
&NA;, &. (1980) · Pain · doi:10.1016/0304-3959(80)90002-0 · Cited by 176
Structure of the rat's behaviour in the hot plate test
ESPEJO, E. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90035-o · Cited by 173
West, W. L., Yeomans, D. C., & Proudfit, H. K. (1993) · Brain Research · doi:10.1016/0006-8993(93)90571-4 · Cited by 173
Bk, T., Peterson, M. W., & Basbaum, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07575.1995 · Cited by 171
Response latencies in the tail-flick test depend on tail skin temperature
Berge, O., Garcia‐Cabrera, I., & Hole, K. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90497-1 · Cited by 169
Coutinho, S. V., Meller, S. T., & Gebhart, G. F. (1996) · Brain Research · doi:10.1016/0006-8993(96)00661-0 · Cited by 169
The orofacial formalin test in rats: effects of different formalin concentrations
Clavelou, P., Dallel, R., Orliaguet, T., Woda, A., & Raboisson, P. (1995) · Pain · doi:10.1016/0304-3959(94)00273-h · Cited by 167
Behavioural effects in rats of morphine and amphetamine and of a combination of the two drugs
Fog, R. (1970) · Psychopharmacology · doi:10.1007/bf00404736 · Cited by 167
Spectral Transmittance and Reflectance of Excised Human Skin
Hardy, J. D., Hammel, H. T., & Murgatroyd, D. (1956) · Journal of Applied Physiology · doi:10.1152/jappl.1956.9.2.257 · Cited by 166
SPINAL WITHDRAWAL REFLEXES IN THE HUMAN LOWER LIMBS
Hagbarth, K. E. (1960) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.3.222 · Cited by 165
EXPERIMENTAL OBSERVATIONS ON HAFFNER'S METHOD FOR TESTING ANALGESIC DRUGS
Bianchi, C., & Franceschini, J. (1954) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1954.tb01681.x · Cited by 165
McMahon, S. B., & Abel, C. (1987) · Pain · doi:10.1016/0304-3959(87)91065-7 · Cited by 164
REFLEX ACTION IN RELATION TO PATTERN AND PERIPHERAL SOURCE OF AFFERENT STIMULATION
Lloyd, D. P. C. (1943) · Journal of Neurophysiology · doi:10.1152/jn.1943.6.2.111 · Cited by 164
The contribution of training to sensitivity in the nociceptive paw-withdrawal test
Taiwo, Y. O., Coderre, T. J., & Levine, J. D. (1989) · Brain Research · doi:10.1016/0006-8993(89)90950-5 · Cited by 163
Tonussi, C. R., & Ferreira, S. H. (1992) · Pain · doi:10.1016/0304-3959(92)90095-s · Cited by 163
Willer, J. C. (1985) · Brain Research · doi:10.1016/0006-8993(85)90719-x · Cited by 162
Kayser, V., & Guilbaud, G. (1983) · Brain Research · doi:10.1016/0006-8993(83)91046-6 · Cited by 155
Satô, A., Sato, Y., & Schmidt, R. F. (1997) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0046598 · Cited by 155
Mogil, J. S., Kest, B., Sadowski, B., & Belknap, J. K. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12304-5 · Cited by 153
A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat
Pircio, A. W., Fedele, C. T., & Bierwagen, M. E. (1975) · European Journal of Pharmacology · doi:10.1016/0014-2999(75)90041-2 · Cited by 151
Assessing mechanical allodynia in the rat paw with a new electronic algometer
Möller, K. Ä., Johansson, B., & Berge, O. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00083-1 · Cited by 151
Coderre, T. J., & Wall, P. D. (1987) · Pain · doi:10.1016/0304-3959(87)90072-8 · Cited by 151
Unmyelinated nociceptive units in two skin areas of the rat
Fleischer, E., Handwerker, H. O., & Joukhadar, S. (1983) · Brain Research · doi:10.1016/0006-8993(83)91041-7 · Cited by 148
FUNCTIONAL CHARACTERISTICS OF AFFERENT FIBERS FROM TOOTH PULP OF CAT
Brookhart, J. M., Livingston, W. K., & Haugen, F. P. (1953) · Journal of Neurophysiology · doi:10.1152/jn.1953.16.6.634 · Cited by 147
Elmer, G. I., Pieper, J. O., Negus, S. S., & Woods, J. H. (1998) · Pain · doi:10.1016/s0304-3959(97)00215-7 · Cited by 146
SITES AND MECHANISMS OF ACTION OF MORPHINE AND RELATED DRUGS IN THE CENTRAL NERVOUS SYSTEM
Wikler, A. (1950) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07085-1 · Cited by 146
Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin
Dallel, R., Raboisson, P., Clavelou, P., Saade, M., & Woda, A. (1995) · Pain · doi:10.1016/0304-3959(94)00212-w · Cited by 142
Evidence for on–off control of heat dissipation from the tail of the rat
Young, A. A., & Dawson, N. J. (1982) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y82-057 · Cited by 141
Giamberardino, M. A., Valente, R., de Bigontina, P., & Vecchiet, L. (1995) · Pain · doi:10.1016/0304-3959(94)00208-v · Cited by 139
Experimentelle Prüfung schmerzstillender Mittel
Haffner, F. (1929) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0028-1126487 · Cited by 139
The Relationship between Cardiovascular and Pain Regulatory Systems
Zamir, N., & Maixner, W. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb14641.x · Cited by 139
Yu, X., Sessle, B. J., Vernon, H. T., & Hu, J. W. (1995) · Pain · doi:10.1016/0304-3959(94)00104-m · Cited by 138
The role of periodontal receptors in the jaw‐opening reflex in the cat.
Dessem, D., Iyadurai, O. D., & Taylor, A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017382 · Cited by 137
Selective reduction of second pain sensations by systemic morphine in humans
Cooper, B. Y., Vierck, C. J., & Yeomans, D. C. (1986) · Pain · doi:10.1016/0304-3959(86)90030-8 · Cited by 137
Baumans, V., Brain, P. F., Brugére, H., Clausing, P., Jeneskog, T., & Perretta, G. (1994) · Laboratory Animals · doi:10.1258/002367794780745308 · Cited by 137
Hensel, H. (1973) · Handbook of sensory physiology · doi:10.1007/978-3-642-65438-1_4 · Cited by 137
McMahon, S. B., Dmitrieva, N., & Koltzenburg, M. (1995) · British Journal of Anaesthesia · doi:10.1093/bja/75.2.132 · Cited by 137
Assessment of Pain in Man and Animals
Chappel, C. (1961) · Nature · doi:10.1038/1911353a0 · Cited by 136
Tail immersion test for the evaluation of a nociceptive reaction in mice
Ramabadran, K., Bansinath, M., Turndorf, H., & Puig, M. M. (1989) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(89)90019-3 · Cited by 134
Schouenborg, J., Weng, H., Kalliom�ki, J., & Holmberg, H. (1995) · Experimental Brain Research · doi:10.1007/bf00241353 · Cited by 134
Measurement of Some Thermal Properties of Human Tissues
Lipkin, M., & Hardy, J. D. (1954) · Journal of Applied Physiology · doi:10.1152/jappl.1954.7.2.212 · Cited by 134
Tillman, D. B., Treede, R., Meyer, R. A., & Campbell, J. N. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020766 · Cited by 133
Grossman, M. L., Basbaum, A. I., & Fields, H. L. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902060103 · Cited by 133
Cadden, S. W., Lisney, S. J. W., & Matthews, B. (1983) · Brain Research · doi:10.1016/0006-8993(83)91280-5 · Cited by 133
Beecher, H. K. (1957) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07211-4 · Cited by 133
Antinociceptive effects of vaginal stimulation in rats: Neurophysiological and behavioral studies
Komisaruk, B. R., & Wallman, J. (1977) · Brain Research · doi:10.1016/0006-8993(77)91014-9 · Cited by 131
Spencer, W. A., Thompson, R. F., & Neilson, D. R. (1966) · Journal of Neurophysiology · doi:10.1152/jn.1966.29.2.221 · Cited by 131
Advances in Animal Welfare Science 1985
Fox, M. W., & Mickley, L. D. (1986) · Springer eBooks · doi:10.1007/978-94-009-4247-9 · Cited by 130
The formalin test in mice: the influence of ambient temperature
Rosland, J. H. (1991) · Pain · doi:10.1016/0304-3959(91)90190-9 · Cited by 130
Weinger, M. B., Segal, I. S., & Maze, M. (1989) · Anesthesiology · doi:10.1097/00000542-198908000-00013 · Cited by 129
Effect of Systemic and Intrathecal Morphine in a Rat Model of Postoperative Pain
Zahn, P. K., Gysbers, D., & Brennan, T. J. (1997) · Anesthesiology · doi:10.1097/00000542-199705000-00010 · Cited by 129
Refinement of animal use-assessment and alleviation of pain and distress
Flecknell, P. A. (1994) · Laboratory Animals · doi:10.1258/002367794780681660 · Cited by 129
REACTION THRESHOLDS TO PRESSURE IN EDEMATOUS HINDPAWS OF RATS AND RESPONSES TO ANALGESIC DRUGS
Winter, C. A., & Flataker, L. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27163-4 · Cited by 128
Afferent impulses in the nerves supplying the urinary bladder
Talaat, M. (1937) · The Journal of Physiology · doi:10.1113/jphysiol.1937.sp003458 · Cited by 126
Tillman, D. B., Treede, R., Meyer, R. A., & Campbell, J. N. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020767 · Cited by 125
Jurna, I., & Heinz, G. (1979) · Brain Research · doi:10.1016/0006-8993(79)91065-5 · Cited by 124
Physiological properties of intradental mechanoreceptors
Dong, W. K., Chudler, E. H., & Martin, R. F. (1985) · Brain Research · doi:10.1016/0006-8993(85)90239-2 · Cited by 124
Accornero, N., Bini, G., Lenzi, G. L., & Manfredi, M. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp012109 · Cited by 122
Spencer, W. A., Thompson, R. F., & Neilson, D. R. (1966) · Journal of Neurophysiology · doi:10.1152/jn.1966.29.2.253 · Cited by 122
Immobilization and restraint effects on pain reactions in animals
Porro, C. A., & Carli, G. (1988) · Pain · doi:10.1016/0304-3959(88)90041-3 · Cited by 121
Functional organization of the nociceptive withdrawal reflexes
Schouenborg, J., Holmberg, H., & Weng, H. (1992) · Experimental Brain Research · doi:10.1007/bf00230929 · Cited by 120
Yu, M., Sessle, B. J., Haas, A. D., Izzo, A. A., Vernon, H. T., & Hu, W. J. (1996) · Pain · doi:10.1016/s0304-3959(96)03181-8 · Cited by 115
Pizziketti, R. J., Pressman, N. S., Geller, E. B., Cowan, A., & Adler, M. W. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90317-6 · Cited by 111
Research works printed but not linked: 31
- Benedetti, 1984, Pathophysiology and therapy of postoperative pain: a review, 373
- Blake, 1963, Grid shock test for analgesics in mice, Med Exp, 9, 146
- Brunaud, 1986, Effets pharmacologiques de la morphine et des morphiniques chez les animaux domestiques, Rec Méd Vét, 162, 1421
- Carroll, 1960, Observations of the neuropharmacology of morphinelike analgesia, Arch Int Pharmacodyn Ther, 125, 383
- Charpentier, 1961, Sur une nouvelle méthode psychophysiologique de mesure quantitative des réactions douloureuses chez le rat, C R Soc Biol, 155, 727
- Cheymol, 1959, Contribution au test de la stimulation électrique de la dent du lapin pour l’étude expérimentale des analgésiques, Therapie, 14, 350
- Collier, 1961, Multiple toe-pinch for testing analgesic drugs, Br J Pharmacol, 17, 28
- Conway, 1983, Plasma catecholamine and cardiovascular responses to morphine and d-ala-d-leu-enkephelin in conscious rats, Arch Int Pharmacodyn Ther, 265, 244
- Dimitrijevic, 1968, Studies of spasticity in man. 3. Analysis of reflex activity evoked by noxious cutaneous stimulation, Brain, 91, 349
- Gemmell, 1977, Cutaneous arteriovenous anastomoses present in the rat tail but absent from the ear of the rat, J Anat, 124, 355
- Gibson TE and Paterson DA eds (1985) The Detection and Relief of Pain in Animals. Proceedings of the Animal Welfare Foundation’s Second Symposium, British Veterinary Association Animal Welfare Foundation, London.
- Gouret, 1975, Test de la pulpe dentaire chez le lapin, J Pharmacol (Paris), 6, 237
- Green, 1951, A comparison of heat and pressure analgesimetric methods in rats, Br J Pharmacol, 6, 572
- Hagbarth, 1952, Excitatory and inhibitory skin areas for flexor and extensor motoneurones, Acta Physiol Scand, 26, 1
- Hardy, 1953, Thesholds of pain and reflex contraction as related to noxious stimulation, J Appl Physiol, 5, 725, 10.1152/jappl.1953.5.12.725 · DOI
- Holmqvist, 1959, On the organization of the supraspinal inhibitory control of interneurons of various spinal reflex arcs, Arch Ital Biol, 97, 340
- Janssen, 1963, The inhibitory effect of fentanyl and other morphine-like analgesics on the warm induced tail withdrawal reflex in rat, Arzneim Forsch, 13, 502
- Knoll, 1955, Experimental studies on the higher nervous activity of animals. I. A method for the elaboration of a non-extinguishable conditioned reflex in the rat, Acta Physiol Hung, 8, 327
- Lewis, 1939, Observations relating to referred pain, visceromotor reflexes and other associated phenomena, Clin Sci, 4, 47
- Linée, 1972, Test des crampes abdominales provoquées chez la souris par la phénylbenzoquinone, J Pharmacol (Paris), 3, 513
- Loux, 1978, Comparative analgesic testing of various compounds in mice using writhing techniques, Arzneim Forsch, 28, 1644
- Lundberg A Integrative significance of patterns of connections made by muscle afferents in the spinal cord Proceedings of the XXIst Symposium of the International Physiology Congress; Buenos Aires, 1959:100–105, International Congress of Physiological Sciences (IUPS)Abstracts of Communications, Buenos Aires.
- Matsumoto, 1967, Epinephrine-induced writhing in mice, Fed Proc, 26, 619
- Matthews, 1986, Responses of intradental nerves to mechanical stimulation of teeth in the cat, J Dent Res, 65, 506
- Merskey, 1979, Pain terms: a list with definitions and notes on usage, Pain, 6, 249
- Michael-Titus, 1988, Multiplicity and limits of nociceptive tests performed for the screening of analgesic agents, Actual Chim Ther, 15, 311
- Naylor, 1964, Studies on sensation to cold stimulation in human teeth, Br Dent J, 117, 482
- Plaghki, 1989, Algesimetry by brief pulses of CO2 laser radiation, Arch Int Physiol Biochem, 97, 82
- Radouco-Thomas, 1957, Méthode algésimétrique expérimentale: étude quantitative de l’action des analgésiques (butazolidine, amidopyrine, morphine, péthidine), Helv Physiol Acta, 15, 193
- Van der Wende, 1956, Analgesic tests based upon experimentally induced acute abdominal pain in rats, Fed Proc, 15, 494
- Wang, 1995, An innovative cold tail-flick test: the cold ethanol tail-flick test, Anesth Analg, 80, 102
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Metadata
- Authors
- Le Bars, D., Gozariu, M., & Cadden, S. W.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 53
- Issue
- 4
- Pages
- 597-652
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W4406058850
- Cited by
- 1,459
- References
- 621
- Citations by year
- 2026: 39 · 2025: 31 · 2024: 22 · 2023: 34 · 2022: 42 · 2021: 52 · 2020: 42 · 2019: 38 · 2018: 64 · 2017: 98 · 2016: 107 · 2015: 121 · 2014: 117 · 2013: 86 · 2012: 87
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- animal models of pain, nociception, animal pain assessment, nociceptive stimuli, thermal pain, mechanical pain, chemical pain, electrical pain, nociceptive threshold, spinal reflexes, inflammation, homeostatic mechanisms
- MeSH terms
- Analgesics, Animals, Disease Models, Animal, Humans, Nerve Fibers, Pain, Pain Measurement
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