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Animal Models of Nociception
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Ethical guidelines for investigations of experimental pain in conscious animals.
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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
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A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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ACETIC ACID FOR ANALGESIC SCREENING
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Cited by
Sorted by citations
Nociceptors: the sensors of the pain pathway
Dubin, A. E., & Patapoutian, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42843 · Cited by 1,418
“Advances are hampered by the difficulties inherent in studying neuronal processes in humans, cellular changes in nociceptors induced by invasive methods, the inability to record directly from the tiny structures where transduction of noxious stimuli occurs, and the uncertainty in model systems that an animal’s behavio…”
BackgroundInfluentialAnimal models of pain: progress and challenges
Mogil, J. S. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2606 · Cited by 1,168
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Regulation of endoplasmic reticulum turnover by selective autophagy
Khaminets, A., Heinrich, T., Mari, M., Grumati, P., Huebner, A. K., Akutsu, M., Liebmann, L., Stolz, A., Nietzsche, S., Koch, N., et al. (2015) · Nature · doi:10.1038/nature14498 · Cited by 956
Structure-based discovery of opioid analgesics with reduced side effects
Manglik, A., Lin, H., Aryal, D. K., McCorvy, J. D., Dengler, D. G., Corder, G. F., Levit, A., Kling, R. C., Bernat, V., Hübner, H., et al. (2016) · Nature · doi:10.1038/nature19112 · Cited by 978
DeWire, S. M., Yamashita, D. S., Rominger, D. H., Liu, G., Cowan, C. L., Graczyk, T. M., Chen, X.-T., Pitis, P. M., Gotchev, D., Yuan, C., et al. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201616 · Cited by 647
A cascade of cytokines mediates mechanical inflammatory hypernociception in mice
Cunha, T. M., Verri, W. A., Jr., Silva, J. S., Poole, S., Cunha, F. Q., & Ferreira, S. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409225102 · Cited by 600
TRPA1 acts as a cold sensor in vitro and in vivo
Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K. Y., Vennekens, R., Nilius, B., & Voets, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808487106 · Cited by 588
“During prolonged exposure to noxious cold stimuli, we could distinguish at least 2 distinct phases in the behavioral response: an acute cold response corresponding with shivering and rubbing together of the paws, followed by brisk lifting of the hind paws and other cold avoidance behaviors (38).”
BackgroundMu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 582
“A full discussion of pain models is beyond the scope of this review, and the reader is referred to another review from this journal (Le Bars et al., 2001).”
BackgroundInfluentialHypernociceptive role of cytokines and chemokines: Targets for analgesic drug development?
Verri, W. A., Jr., Cunha, T. M., Parada, C. A., Poole, S., Cunha, F. Q., & Ferreira, S. H. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.04.001 · Cited by 538
Tests and models of nociception and pain in rodents
Barrot, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.041 · Cited by 488
“Nociceptive response to chemical stimuli Different irritating chemical agents can be used as nociceptive stimuli (Le Bars et al., 2001); Negus et al., 2006) to assess pain and preclinically evaluate analgesic drugs.”
BackgroundInfluentialVasudeva, R., Rutkowski, M. D., & DeLeo, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09980.2002 · Cited by 468
“The various animal models used may have a fundamentally different pathophysiology (Bars et al., 2001), and the sensitivity to opioids may vary accordingly (McCormack et al.”
BackgroundGribkoff, V. K., & Kaczmarek, L. K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.021 · Cited by 379
“…conditions mimicking many aspects of their human disease counterparts, have seldom proven predictive to this point (Bird and Parlee, 2000; Branchi et al., 2003; Cernak, 2005; Gamzu, 1985; le Bars et al., 2001; McGonigle, 2014; Petters and Sommer, 2000; Tordjman et al., 2007; Windisch, 2014).”
Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review
Urîtu, C. M., Mihai, C. T., Stanciu, G. D., Dodi, G., Alexa‐Stratulat, T., Luca, A., Leon, M. M., Ştefănescu, R., Bild, V., Melnic, S., et al. (2018) · Pain Research and Management · doi:10.1155/2018/7801543 · Cited by 398
“+e hot-plate and tail immersion tests are reported to be useful tests in discriminating analgesic agents acting primarily at the spinal medulla level and at higher central nervous system levels (positive results) from those acting through peripheral mechanisms (negative results) [391].”
BackgroundThe role of sleep in pain and fibromyalgia
Choy, E. H. S. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.56 · Cited by 333
α-Terpineol, a natural monoterpene: A review of its biological properties
Khaleel, C., Tabanca, N., & Buchbauer, G. (2018) · Open Chemistry · doi:10.1515/chem-2018-0040 · Cited by 345
Opioid Analgesia and Opioid-Induced Adverse Effects: A Review
Paul, A. K., Smith, C. M., Rahmatullah, M., Nissapatorn, V., Wilairatana, P., Spetea, M., Gueven, N., & Dietis, N. (2021) · Pharmaceuticals · doi:10.3390/ph14111091 · Cited by 332
Evaluation of animal models of neurobehavioral disorders
van der Staay, F. J., Arndt, S. S., & Nordquist, R. E. (2009) · Behavioral and Brain Functions · doi:10.1186/1744-9081-5-11 · Cited by 319
“Although discomfort may inevitably be part of animal models of neurobehavioral disorders [130,131], a careful evaluation must enable us to decide whether the observed dysfunctions and associated discomfort are part of the phenotype under consideration, or whether action is indicated to reduce the discomfort.”
Diffuse Noxious Inhibitory Controls (DNIC)
Bars, D. L., & Willer, J. C. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00193-6 · Cited by 292
Pethö, G., & Reeh, P. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00048.2010 · Cited by 299
Gleerup, K. B., Forkman, B., Lindegaard, C., & Andersen, P. H. (2014) · Veterinary Anaesthesia and Analgesia · doi:10.1111/vaa.12212 · Cited by 287
“Topically applied capsaicin is used as a pain model in humans (Baron et al. 1999) to mimic clinical pain (Le Bars et al. 2001) and a topical application of low concentration capsaicin cream has been reported to cause a pain reaction in horses (Seino et al. 2003).”
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
Minett, M. S., Nassar, M. A., Clark, A. K., Passmore, G. M., Dickenson, A. H., Wang, F., Malcangio, M., & Wood, J. N. (2012) · Nature Communications · doi:10.1038/ncomms1795 · Cited by 286
King, C. D., Wong, F., Currie, T., Mauderli, A. P., Fillingim, R. B., & Riley, J. L. (2009) · Pain · doi:10.1016/j.pain.2008.12.027 · Cited by 284
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human
Morgan, M. M., & Christie, M. J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01335.x · Cited by 273
Preclinical Assessment of Candidate Analgesic Drugs: Recent Advances and Future Challenges
Negus, S. S., Vanderah, T. W., Brandt, M. R., Bilsky, E. J., Becerra, L. R., & Borsook, D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.106377 · Cited by 255
“In addition to thermal stimuli, other commonly used modalities include electrical, mechanical, and chemical noxious stimuli (Dykstra, 1985; Bennett, 2001; Le Bars et al., 2001; Mogil et al., 2001).”
BackgroundMethodde Azevedo, M. I., Pereira, A. F., Nogueira, R. B., Rolim, F. E., Brito, G. A., Wong, D. V. T., Lima‐Júnior, R. C. P., Ribeiro, R. D. A., & Vale, M. L. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-53 · Cited by 254
“In a review published by Le Bars and colleagues [22] the influence of species and animal”
BackgroundSantos, S. S., Santos, S., Pinto, A. R. T., Ramu, V. G., Heras, M., Bardajı́, E., Tavares, I., & Castanho, M. A. R. B. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00001 · Cited by 250
“However, we can not exclude, despite efforts to habituate all animals to the analgesimeter, the lower pain threshold in 2VOvehicle females may reflect an anxiety-related behavior (an aggravating factor for experimental/clinical pain) (Le Bars et al., 2001).”
BackgroundHuman Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs
Olesen, A. E., Andresen, T., Staahl, C., & Drewes, A. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005447 · Cited by 249
“However , the absence of verbal communication in animals is an obstacle to the evaluation of pain, and assessment can mainly be estimated by examining an animal's response (neurophysiological or behavioral) to nociceptive stimuli (Le Bars et al., 2001; Dolgin, 2010).”
BackgroundInfluentialP2X4 receptors mediate PGE2 release by tissue‐resident macrophages and initiate inflammatory pain
Ulmann, L., Hirbec, H., & Rassendren, F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.126 · Cited by 229
“Intensities of formalin-induced responses are dose dependent (Le Bars et al, 2001).”
BackgroundAttenuated pain responses in mice lacking CaV3.2 T‐type channels
Choi, S., Na, H. S., Kim, J., Lee, J., Lee, S., Kim, D., Park, J., Chen, C., Campbell, K. P., & Shin, H. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00268.x · Cited by 229
“licking duration of the early phase, which is elicited by direct stimulation of peripheral nociceptors ( Le Bars et al. 2001 ), whereas the licking duration of the late phase was increased (data not shown).”
Bioassay‐guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol
Guimarães, A. G., Oliveira, G. F., Seabra, M. S. D. M., Cavalcanti, S. C. H., Antoniolli, Â. R., Bonjardim, L. R., Silva, F. A., dos Santos, J. P. A., da Rocha, R. F., Moreira, J. C. F., et al. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2010.00609.x · Cited by 225
Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C. J., Johnson, P. L., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., et al. (2011) · Nature Medicine · doi:10.1038/nm.2345 · Cited by 223
“Phase 1 of the formalin test results from direct stimulation of nociceptors, whereas phase 2 involves a period of central sensitization during which inflammatory phenomena occu”
BackgroundPreclinical Assessment of Inflammatory Pain
Muley, M. M., Krustev, E., & McDougall, J. J. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12486 · Cited by 224
“These writhing responses include abdominal stretching, flinching, licking, and motor incoordination [135].”
BackgroundA Review of Pain Assessment Methods in Laboratory Rodents
Turner, P. V., Pang, D., & Lofgren, J. L. S. (2019) · Comparative Medicine · doi:10.30802/aalas-cm-19-000042 · Cited by 196
Animal models of chronic pain: Advances and challenges for clinical translation
Burma, N. E., Leduc‐Pessah, H., Fan, C. Y., & Trang, T. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23768 · Cited by 198
Phenolic composition and biological activities of Salvia halophila and Salvia virgata from Turkey
Akkol, E. K., Göğer, F., Koşar, M., & Başer, K. H. C. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2007.11.071 · Cited by 192
Farouk, L., Laroubi, A., Aboufatima, R., Ahmed Benharref, A., & Chait, A. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.10.014 · Cited by 188
Predictive validity of behavioural animal models for chronic pain
Berge, O. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01300.x · Cited by 188
“…exact focus of the beam and the adaptation temperature of the skin, which may be altered by the model itself, handling and procedures in the testing environment and by pharmacological effects of test compounds (Bennett and Xie, 1988; Luukko et al., 1994; Dirig et al., 1997; Le Bars et al., 2001).”
BackgroundMethodInfluentialDecreased alertness due to sleep loss increases pain sensitivity in mice
Alexandre, C., Latrémolière, A., Ferreira, A. N., Miracca, G., Yamamoto, M., Scammell, T. E., & Woolf, C. J. (2017) · Nature Medicine · doi:10.1038/nm.4329 · Cited by 171
Burrowing Behavior as an Indicator of Post-Laparotomy Pain in Mice
Jirkof, P., Cesarovic, N., Rettich, A., Nicholls, F., Seifert, B., & Arras, M. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00165 · Cited by 172
“Frontiers in Behavioral Neuroscience www.frontiersin.org October 2010 | Volume 4 | Article 165 | 1 BEHAVIORAL NEUROSCIENCE Methods Article published: 12 October 2010 doi: 10.3389/fnbeh.2010.00165 Chapman et al., 1985; Le Bars et al., 2001; Mogil, 2009).”
BackgroundInfluentialPain and depression comorbidity: A preclinical perspective
Li, J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.042 · Cited by 175
Biessels, G. J., Bril, V., Calcutt, N. A., Cameron, N. E., Cotter, M. A., Dobrowsky, R. T., Feldman, E. L., Fernyhough, P., Jakobsen, J., Malik, R. A., et al. (2014) · Journal of the Peripheral Nervous System · doi:10.1111/jns5.12072 · Cited by 168
“It was recognized that the pertinence of aversive behavioral tests to the spontaneous pain of many diabetic patients may be limited and that many caveats should be acknowledged when extrapolating from pain-related behaviors in animals to the human condition (Le Bars et al., 2001).”
BackgroundPros and Cons of Clinically Relevant Methods to Assess Pain in Rodents
Tappe‐Theodor, A., King, T. E., & Morgan, M. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.009 · Cited by 165
Quercetin Reduces Inflammatory Pain: Inhibition of Oxidative Stress and Cytokine Production
Valério, D. A. R., Georgetti, S. R., Magro, D. A., Casagrande, R., Cunha, T. M., Vicentini, F. T. M. C., Vieira, S. M., Fonseca, M. J. V., Ferreira, S. H., Cunha, F. Q., et al. (2009) · Journal of Natural Products · doi:10.1021/np900259y · Cited by 164
Sciatic nerve cuffing in mice: A model of sustained neuropathic pain
Benbouzid, M., Pallage, V., Rajalu, M., Waltisperger, E., Doridot, S., Poisbeau, P., Freund‐Mercier, M. J., & Barrot, M. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.10.002 · Cited by 177
“Pain is a fundamental alarm system and is crucial for survival (Le Bars et al., 2001; Scholz and Woolf, 2002).”
BackgroundIsa, I. L. M., Abbah, S. A., Kilcoyne, M., Sakai, D., Dockery, P., Finn, D. P., & Pandit, A. S. (2018) · Science Advances · doi:10.1126/sciadv.aaq0597 · Cited by 159
Tetrodotoxin (TTX) as a Therapeutic Agent for Pain
Nieto, F. R., Cobos, E. J., Tejada, M. A., Sánchez–Fernández, C., González‐Cano, R., & Cendán, C. M. (2012) · Marine Drugs · doi:10.3390/md10020281 · Cited by 157
“produces a second phase involving inflammation [112].”
Targeting ASIC1a Reduces Innate Fear and Alters Neuronal Activity in the Fear Circuit
Coryell, M. W., Ziemann, A. E., Westmoreland, P., Haenfler, J. M., Kurjakovic, Z., Zha, X., Price, M. P., Schnizler, M. K., & Wemmie, J. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.008 · Cited by 146
Almeida, J. R. G. D. S., Souza, G. R., Silva, J. C., de Lima-Saraiva, S. R. G., Júnior, R. G. D. O., Quintans, J. D. S. S., Barreto, R. D. S. S., Bonjardim, L. R., Cavalcanti, S. C. H., & Quintans‐Júnior, L. J. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/808460 · Cited by 145
“This is a classical model widely used to screen new agents with analgesic profile where both neurogenic and/or inflammatory pain is involved [17].”
BackgroundInfluentialModality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons
Pouchelon, G., Gambino, F., Bellone, C., Telley, L., Vitali, I., Lüscher, C., Holtmaat, A. J. D. G., & Jabaudon, D. (2014) · Nature · doi:10.1038/nature13390 · Cited by 143
Negri, L., Lattanzi, R., Giannini, E., Colucci, M., Margheriti, F., Melchiorri, P., Vellani, V., Tian, H., Felice, M. D., & Porreca, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5403-05.2006 · Cited by 143
“*p 0.05, **p 0.01, and ***p 0.001 versus baseline values (2-way ANOVA with Bonferroni’s post test) significant within the noxious temperature range from 46 to 50°C, the operating range of C-polymodal nociceptors and the vanilloid channel TRPV1 (Le Bars et al., 2001; Tominaga and Tominaga, 2005).”
BackgroundInfluentialLuccarini, P., Childeric, A., Gaydier, A.-M., Voisin, D. L., & Dallel, R. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.04.010 · Cited by 140
The Effects of Essential Oils on the Nervous System: A Scoping Review
Sattayakhom, A., Wichit, S., & Koomhin, P. (2023) · Molecules · doi:10.3390/molecules28093771 · Cited by 140
Gabriel, A. F., Marcus, M. A. E., Honig, W. M. M., Walenkamp, G. H. I. M., & Joosten, E. A. J. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.02.003 · Cited by 139
Marker, C. L., Stoffel, M., & Wickman, K. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5251-03.2004 · Cited by 137
“…indistinguishably from wild-type mice in the tailflick assay, which for the short latency responses does not require supraspinal integration (Le Bars et al., 2001), it seems reasonable to suggest that GIRK3-containing channels may contribute to the tone of descending modulatory pathways or…”
BackgroundInfluentialZinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit
Nozaki, C., Vergnano, A. M., Filliol, D., Ouagazzal, A., Goff, A. L., Carvalho, S., Reiss, D. J., Gavériaux‐Ruff, C., Neyton, J., Paoletti, P., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2844 · Cited by 134
“0 °C s −1 , tail immersion and hot plate tests) preferentially recruit Aδ fiber”
BackgroundPain assessment in animal models of osteoarthritis
Piel, M. J., Kroin, J. S., van Wijnen, A. J., Kc, R., & Im, H. (2013) · Gene · doi:10.1016/j.gene.2013.11.091 · Cited by 135
Nociceptive behavior in animal models for peripheral neuropathy: Spinal and supraspinal mechanisms
Saadé, N. E., & Jabbur, S. J. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.06.002 · Cited by 130
Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents
Yalçın, İ., Charlet, A., Freund‐Mercier, M. J., Barrot, M., & Poisbeau, P. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.01.325 · Cited by 128
Arthritis and pain. Future targets to control osteoarthritis pain
Dray, A., & Read, S. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2178 · Cited by 128
“nistic exploration of excitability changes in pain pathways [167].”
BackgroundHajhashemi, V., Sajjadi, S. E., & Heshmati, M. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.05.012 · Cited by 127
Wang, X., Zhang, J., Eberhart, D. E., Urban, R., Meda, K., Solórzano, C., Yamanaka, H., Rice, D. S., & Basbaum, A. I. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.001 · Cited by 129
“However, in the hot plate test, which triggers a behavioral response (licking of the paw) that involves both spinal cord and supraspinal processing of pain messages (Langerman et al., 1995; Le Bars et al., 2001), the cKO mice had significantly higher response latencies (Figure 2C).”
BackgroundStaahl, C., Olesen, A. E., Andresen, T., Arendt‐Nielsen, L., & Drewes, A. M. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03456.x · Cited by 126
Giminiani, P. D., Brierley, V. L. M. H., Scollo, A., Gottardo, F., Malcolm, E. M., Edwards, S. A., & Leach, M. C. (2016) · Frontiers in Veterinary Science · doi:10.3389/fvets.2016.00100 · Cited by 124
Boonyarikpunchai, W., Sukrong, S., & Towiwat, P. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.004 · Cited by 124
Relative contribution of peripheral versus central opioid receptors to antinociception
Łabuz, D., Mousa, S. A., Schäfer, M., Stein, C., & Machelska, H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.049 · Cited by 124
Kappa opioids and the modulation of pain
Kivell, B. M., & Prisinzano, T. E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1819-6 · Cited by 123
Pacheco, D. D. F., Romero, T. R. L., & Duarte, I. D. G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.026 · Cited by 122
Quintans‐Júnior, L. J., Moreira, J. C. F., Pasquali, M. A. D. B., Rabie, S. M. S., Pires, A. S., Schröder, R., Rabelo, T. K., dos Santos, J. P. A., Lima, P. S. S., Cavalcanti, S. C. H., et al. (2013) · ISRN Toxicology · doi:10.1155/2013/459530 · Cited by 122
The Influence of Non-Nociceptive Factors on Hot-Plate Latency in Rats
Gunn, A., Bobeck, E. N., Weber, C. J., & Morgan, M. M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.06.011 · Cited by 122
Hajhashemi, V., Ghannadi, A., & Hajiloo, M. (2010) · Europe PMC (PubMed Central) · Cited by 122
Clutton, R. E. (2010) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2010.07.002 · Cited by 121
“Furthermore, both heat and electrical current produce phasic pain of short duration that responds less to analgesics than tonic pain.(34) New techniques using electrophysiologic methods to investigate the pharmacologic modulation of nociception (eg, the nociceptive withdrawal reflex [NWR] and temporal summation) have…”
BackgroundXu, Y., Qiu, H., Liu, H., Liu, M., Huang, Z.-Y., Yang, J., Su, Y., & Yu, C. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.02.009 · Cited by 120
Up–Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds
González‐Cano, R., Boivin, B., Bullock, D., Cornelissen, L., Andrews, N., & Costigan, M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00433 · Cited by 118
“As such, they have become a mainstay of clinical and pre-clinical research of mechanosensation (Le Bars et al., 2001; Cornelissen et al., 2013, 2014).”
BackgroundDivergent brainstem opioidergic pathways that coordinate breathing with pain and emotions
Liu, S., Ye, M., Pao, G. M., Song, S. M., Jhang, J., Jiang, H., Kim, J., Kang, S. J., Kim, D., & Han, S. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.029 · Cited by 116
Citronellol, a monoterpene alcohol, reduces nociceptive and inflammatory activities in rodents
de Brito, R. G., Guimarães, A. G., Quintans, J. D. S. S., dos Santos, M. R. V., de Sousa, D. P., Badauê‐Passos, D., de Lucca, W., Brito, F. A., Barreto, E., de Oliveira, A. P., et al. (2012) · Journal of Natural Medicines · doi:10.1007/s11418-012-0632-4 · Cited by 115
“Substances and drugs that produce strong inhibitory effects in the hot plate test can inhibit centrally induced pain and act as analgesics [32, 39].”
BackgroundInfluentialRapid Regulation of Pain by Estrogens Synthesized in Spinal Dorsal Horn Neurons
Evrard, H., & Balthazart, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1638-04.2004 · Cited by 115
“We recorded the latency before the subject withdrew its foot from water in a rapid reflex-like motion as described previously (Le Bars et al., 2001; Evrard and Balthazart, 2002a).”
Randall-Selitto Test: A New Approach for the Detection of Neuropathic Pain after Spinal Cord Injury
Santos-Nogueira, E., Redondo‐Castro, E., Mancuso, R., & Navarro, X. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1700 · Cited by 114
“Some of the most commonly used tests, in particular the Von Frey filaments (Detloff et al., 2010; Hogan et al., 2004; Le Bars et al., 2001) and the electronic Von Frey aesthesiometer (Liu et al., 2008), are designed for the detection of cutaneous mechanical hyperalgesia by applying mechanical…”
Pitychoutis, P. M., Nakamura, K., Tsonis, P. A., & Papadopoulou‐Daifoti, Z. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.072 · Cited by 119
Yin, Z., Li, L., Chu, S., Sun, Q., Ma, Z.-L., & Gu, X. (2016) · Scientific Reports · doi:10.1038/srep27129 · Cited by 112
A functional subdivision within the somatosensory system and its implications for pain research
Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.015 · Cited by 112
Narita, M., Nakamura, A., Masahiko, O., Imai, S., Miyoshi, K., Suzuki, M., & Suzuki, T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301471 · Cited by 110
“When the intensity of stimulation was enough to produce a basal movement within 3–5 s in mice, it was defined that pharmacological observation results from the spinal reflex and supraspinal modulations (”
BackgroundBradman, M., Ferrini, F., Salio, C., & Merighi, A. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.08.010 · Cited by 107
“Monofilaments are now used extensively in medicine (Armstrong et al. 1998; Jerosch-Herold 2005) and preclinical neuroscience (Le Bars et al. 2001), often to assess pain in the hope of therapeutic translatability (Mogil 2009); yet the quantification of rodent behaviour by hair applications has…”
Translational pain assessment: could natural animal models be the missing link?
Klinck, M. P., Mogil, J. S., Moreau, M., Lascelles, B. D. X., Flecknell, P. A., Poitte, T., & Troncy, É. (2017) · Pain · doi:10.1097/j.pain.0000000000000978 · Cited by 110
“False positives may also arise because of effects other than analgesia (eg, sedation and anxiolysis) although incorporation of appropriate additional assays to detect such factors may reduce this problem.(80,104) In”
BackgroundCobianchi, S., de Cruz, J., & Navarro, X. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.02.008 · Cited by 107
“2A. Intensity was set to low power (40 mW/cm2)with a heating rate of 1 °C/s, to induce activation of unmyelinated fibers (Le Bars et al., 2001).”
BackgroundStevenson, G. W., Bilsky, E. J., & Negus, S. S. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.01.447 · Cited by 105
Analgesic Potential of Essential Oils
Sarmento-Neto, J. F., do Nascimento, L. G., Felipe, C. F. B., & de Sousa, D. P. (2015) · Molecules · doi:10.3390/molecules21010020 · Cited by 107
“Nociceptive tests may use chemical, electrical, mechanical, or thermal stimuli [3].”
BackgroundInfluentialAnti-inflammatory and antinociceptive activities of indole–imidazolidine derivatives
Guerra, A. S. H. D. S., Malta, D. J. D. N., Laranjeira, L. P. M., Maia, M. B. D. S., Colaço, N. C., de Lima, M. D. C. A., Galdino, S. L., Pitta, I. D. R., & Gonçalves-Silva, T. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.07.010 · Cited by 102
Guo, T., Deng, Y., Xie, H. W., Yao, C., Cai, C.-C., Pan, S., & Wang, Y.-L. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.11.004 · Cited by 102
Kayser, V., Aubel, B., Hamon, M., & Bourgoin, S. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704979 · Cited by 101
“Indeed, anatomical and embryological di erences exist between trigeminal and spinal nerves (Le Douarin & Kalcheim, 1999), which may account for the di erence in sensitivity to triptans.”
BackgroundChallenges in the Search for Drugs to Treat Central Nervous System Disorders
Enna, S. J., & Williams, M. C. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.143420 · Cited by 100
Tham, S. M., Angus, J. A., Tudor, E. M., & Wright, C. E. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706045 · Cited by 98
“Another possibility is that the choice of a 12 s cutoff time for the tail flick assay, compared to the 50 s of the hot plate test, may have led to an ‘apparent’ increased sensitivity due to this ‘arbitrary’ maximum, designed to avoid tissue injury (Le Bars et al., 2001).”
BackgroundMethodInfluentialAnalgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice
Ahmad, N. S., Waheed, A., Farman, M., & Qayyum, A. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.03.017 · Cited by 98
Pires, J. M., Mendes, F. R., Negri, G., Duarte‐Almeida, J. M., & Carlini, E. A. (2008) · Phytotherapy Research · doi:10.1002/ptr.2589 · Cited by 98
Pedersen, L. H., Nielsen, A. N., & Blackburn-Munro, G. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0120-6 · Cited by 97
“Tail-flick test To test for a possible spinal site of analgesic action on acute nociceptive processing, drugs were administered to normal, uninjured rats in the tail-flick test (Le Bars et al. 2001).”
MethodAntinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis
Gorzalczany, S. B., Marrassini, C., Miño, J., Acevedo, C., & Ferraro, G. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.01.025 · Cited by 97
Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice
Chao, J., Lu, T.-C., Liao, J., Huang, T.-H., Lee, M., Cheng, H., Ho, L., Kuo, C.-L., & Peng, W. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.06.024 · Cited by 96
Modeling Nociception in Zebrafish: A Way Forward for Unbiased Analgesic Discovery
Curtright, A., Rosser, M., Goh, S., Keown, B., Wagner, E., Sharifi, J., Raible, D. W., & Dhaka, A. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116766 · Cited by 96
“While may not be possible to measure pain due to its complexity in animal model systems, measurement of nociception, the behavioral response to noxious stimuli, is routinely used to measure the efficacy of potentially analgesic compounds [3, 4].”
BackgroundDevelopment of a Mouse Pain Scale Using Sub-second Behavioral Mapping and Statistical Modeling
Abdus-Saboor, I., Fried, N. T., Lay, M., Burdge, J., Swanson, K. A., Fischer, R., Jones, J. M., Dong, P., Cai, W., Guo, X., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.017 · Cited by 95
Thermal and mechanical nociceptive threshold testing in horses: a review
Love, E. J., Murrell, J. C., & Whay, H. (2011) · Veterinary Anaesthesia and Analgesia · doi:10.1111/j.1467-2995.2010.00580.x · Cited by 95
“A change in the current applied to the bulb can alter the volume of skin that is stimulated which introduces a systematic and unquantifiable error in the measurement (Le Bars et al. 2001).”
Background
Metadata
- Authors
- Le Bars, D., Gozariu, M., & Cadden, S. W.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 53
- Issue
- 4
- Pages
- 597-652
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W4406058850
- Cited by
- 1,459
- References
- 621
- Citations by year
- 2026: 39 · 2025: 31 · 2024: 22 · 2023: 34 · 2022: 42 · 2021: 52 · 2020: 42 · 2019: 38 · 2018: 64 · 2017: 98 · 2016: 107 · 2015: 121 · 2014: 117 · 2013: 86 · 2012: 87
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- animal models of pain, nociception, animal pain assessment, nociceptive stimuli, thermal pain, mechanical pain, chemical pain, electrical pain, nociceptive threshold, spinal reflexes, inflammation, homeostatic mechanisms
- MeSH terms
- Analgesics, Animals, Disease Models, Animal, Humans, Nerve Fibers, Pain, Pain Measurement
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