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Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man.
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In the citing paper
“Both THC and CBD are predominantly metabolized, by the liver, through the action of the cytochrome P450 system.104,105”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [105]
In the citing paper
“however, it should be pointed out that previous investigations have not been able to confirm whether there is a direct relationship between plasma levels of cannabinoids, in particular CBD, and their clinical effects (Agurell et al, 1986).”
From Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011) · cites this paper as Agurell et al, 1986
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Items 301–400 of 409
Cannabinoids‐Human Physiology and Agronomic Principles for Production
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“Mechoulam et al (1970) reported redness of the eyes and “ptosis” in Rhesus monkeys given intravenous THC. Agurell et al (1986) stated that in general, conjunctival suffusion was evident at plasma levels of THC above 5 ng/mL. Observation of the ocular venous system and measurement of intraocular…”
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Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
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Psychotomimetic and Cognitive Effects of Δ 9 -Tetrahydrocannabinol in Laboratory Settings
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Interaction of cytochrome P450 3A4 with cannabinoids and the drug darifenacin
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“Cannabinoids are extensively metabolized by hepatic CYPs, with over 40 metabolites of THC identified in humans (23).”
Cannabis and Cannabinoids (PDQ
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Cannabis and Drug-Facilitated Crimes
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[Dietary intakes in a group of marihuana smoking patients].
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Cannabis for Multiple Sclerosis
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Δ9-THC Hemisuccinate in Suppository Form as an Alternative to Oral and Smoked THC
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Chronic Δ9-Tetrahydrocannabinol Inhalation Following Osteoporosis Results in Bone Deficits
Powell, A., Clouse, G., Penman, S. L., Taylor, I. T., Sadar, F., Ehan, N., Varma, A., Hadjiargyrou, M., Komatsu, D. E., & Thanos, P. K. (2026) · Biomedicines · doi:10.3390/biomedicines14071620 · Cited by 1
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Cannabinoids as Potent Inhibitors of Human CYP1 Enzymes
Watanabe, K., Yamaori, S., Masuda, K., Katsu, T., Narimatsu, S., & Yamamoto, I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00096-x · Cited by 1
Effekter av cannabis varer lenger enn antatt
Mørland, J. G., & Bramness, J. G. (2017) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.17.0429 · Cited by 1
Cannabis Chemistry: Cannabinoids in Cannabis, Humans, and Other Species
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Fahrtüchtigkeit, Fahreignung und Cannabiskonsum
Grotenhermen, F. (2002) · Springer eBooks · doi:10.1007/978-3-642-56070-5_9 · Cited by 1
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Konkin, D. J. F. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)
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Toxicocinétique et distribution tissulaire du delta-9-tétrahydrocannabinol : étude chez le porc
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“Il existe de nombreux métabolites mineurs qui ont été identifiés chez l’homme ou l’animal et qui ont des fonctions acides ou hydroxyl sur des positions différentes (26).”
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Look Back in Ananda—40 Years of Research on Cannabinoids
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Use Disorders of Cocaine and Methamphetamine
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Tranquilizers and Sedative Use Disorders
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Genetic Influence on Substance Use Disorders
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Brain Function and Substance Use Disorders
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Tobacco Use and Nicotine Addiction
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Behavioral, Cognitive, and Social Factors Promoting SUD
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Geschwinde, T. (2012) · Springer eBooks · doi:10.1007/978-3-642-30163-6_1
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Diagnosis of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.003
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Treatment of Substance Use Disorders
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“Δ-9-tetrahydrocannabinol (Δ-9 THC), a compound derived from Cannabis Sativa was first isolated in 1964, and is now known for its psychoactive and orexigenic effects (Agurell et al., 1986; Gaoni & Mechoulam, 1964).”
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International Effect: The Ongoing Tension with Medical Marijuana Legalization
Vadasz, G. (2024) · International Journal of Law and Policy · doi:10.47604/ijlp.2261
Metadata
- Authors
- Agurell, S., Halldin, M., Lindgren, J. E., Ohlsson, A., Widman, M., Gillespie, H., & Hollister, L.
- ORCID
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 38
- Issue
- 1
- Pages
- 21-43
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2107684761
- Cited by
- 406
- References
- 0
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 45 · 2019: 17 · 2018: 12 · 2017: 11 · 2016: 21 · 2015: 14 · 2014: 14 · 2013: 8 · 2012: 10
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- delta-1-tetrahydrocannabinol, cannabinoids, pharmacokinetics, drug metabolism, human metabolism
- MeSH terms
- Animals, Biotransformation, Cannabidiol, Cannabinoids, Drug Tolerance, Feces, Humans, Kinetics, Dronabinol, Tissue Distribution
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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