Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness
Open accessAbstract
Study objectives There is accumulating evidence that the common cold produces impairments in psychomotor vigilance. This has led some investigators to hypothesize that such illnesses may also have disruptive effects on sleep. While several self-report studies suggest that viral illness may influence sleep parameters, no studies have assessed polysomnographically recorded sleep following viral infections.Design Parallel control group comparison.Setting Sleep laboratory in a large urban medical center.Participants Twenty-one men and women with susceptibility to the rhinovirus type 23.Interventions Nasal inoculation with rhinovirus type 23.Measurements Polysomnographically recorded sleep for five nights (2300-0700 h) post-viral inoculation. Twice daily (1030 and 1430 h) performance assessment during each experimental day using auditory vigilance and divided attention tasks. A multiple sleep latency test (MSLT) was performed daily for the duration of the study.Results In symptomatic individuals, total sleep time decreased an average of 23 min, consolidated sleep decreased an average of 36 min, and sleep efficiency was reduced by an average of 5% during the active viral period (experimental days/nights 3-5) compared with the incubation period. Psychomotor performance was impaired. These changes were significantly greater than those observed in asymptomatic individuals.Conclusions The common cold can have detrimental effects on sleep and psychomotor performance in symptomatic individuals during the initial active phase of the illness.
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Infection with rhinovirus 23 in healthy human volunteers increases total sleep time.
“Drake et al (2000) demonstrated in healthy human volunteers that infection with rhinovirus 23 (HRV-23) increases total sleep time.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Drake et al, 2000
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The Sleep-Immune Crosstalk in Health and Disease
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“In the only study that, to our knowledge, recorded sleep using PSG in this context, rhinovirus-type-23-induced common colds disrupted sleep in symptomatic individuals, as evidenced by reduced total sleep time and reduced sleep efficiency in the active phase of the illness (158).”
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Self-citation
- Authors
- Drake, C. L., Roehrs, T. A., Royer, H., Koshorek, G., Turner, R. B., & Roth, T.
- Affiliations
- Henry Ford Health (US)
- Medical University of South Carolina (US)
- Corresponding author
- Drake, Christopher L
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 71
- Issue
- 1-2
- Pages
- 75-81
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC7134541
- OpenAlex
- W2018447595
- Cited by
- 71
- References
- 22
- Citations by year
- 2025: 2 · 2024: 5 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- common cold, sleep, psychomotor performance, daytime alertness, sleep efficiency, total sleep time, sleep consolidation, multiple sleep latency test, divided attention, auditory vigilance, viral infection, nasal inoculation
- MeSH terms
- Adolescent, Adult, Affect, Attention, Common Cold, Female, Humans, Male, Middle Aged, Psychomotor Performance, Rhinovirus, Sleep, Polysomnography
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