Perceived Immune Status and Sleep: A Survey among Dutch Students
Open accessAbstract
Reduced immune functioning may have a negative impact on sleep and health, and vice versa. A survey among Dutch young adults (18–35 years old) was administered to collect information on perception of reduced immunity and its relationship to sleep disorders, sleep duration, and quality. Sleep disorders were assessed with the SLEEP-50 questionnaire subscales of sleep apnea, insomnia, circadian rhythm disorder, and daily functioning. Dutch young adults (N= 574) completed the survey. Among them, subjects (N= 209; 36.4%) reported perceived reduced immunity. Relative to those with a normal immune status, subjects reporting reduced immunity had significantly higher scores(p=0.0001)on sleep apnea (2.6 versus 3.6), insomnia (5.1 versus 6.8), and circadian rhythm disorder (2.1 versus 2.7). Subjects reporting reduced immunity also had significantly poorer daily functioning scores (5.4 versus 7.6,p=0.0001). No differences were observed in total sleep time, but those reporting reduced immunity had significantly poorer ratings of sleep quality (6.8 versus 7.2,p=0.0001). Our findings suggest that perceived reduced immunity is associated with sleep disturbances, impaired daily functioning, and a poorer sleep quality. Experimental studies including the assessment of immune biomarkers and objective measures of sleep (polysomnography) should confirm the current observations.
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Leukocytes can sense and synthesize neuroendocrine mediators of the hypothalamic, pituitary, and glandular level and can form their own local neuroendocrine axis in an autocrine and paracrine manner.
“Leukocytes can sense and synthesize a plethora of neuroendocrine mediators of the hypothalamic, pituitary, and glandular level [e.g., corticotropin releasing hormone, adrenocorticotropic hormone, cortisol; growth hormone releasing hormone, growth hormone (GH), insulin-like growth factor-1; dopamine, prolactin] and can even form an own, local neuroendocrine axis in an autocrine and paracrine manner”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [155]
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- Authors
- Donners, A. A. M. T., Tromp, M. D. P., Garssen, J., Roth, T., & Verster, J. C.
- Affiliations
- Henry Ford Health (US)
- Utrecht University (NL)
- Corresponding author
- Verster, Joris C.
- Venue
- Sleep Disorders
- Publisher
- Hindawi Limited
- Published
- 2015
- Volume
- 2015
- Pages
- 1-5
- ISSN
- 2090-3545 (ISSN-L)
- 2090-3553
- PMC
- PMC4581572
- OpenAlex
- W1907355990
- Cited by
- 40
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 3
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Sleep Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (cc-by)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep apnea, insomnia, circadian rhythm disorders, sleep quality, daily functioning, young adults
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