FOS Immunoreactivity After Exposure to Conspecific or Heterospecific Urine
Abstract
Female prairie voles (Microtus ochrogaster) typically require an intact vomeronasal system and exposure to a chemical signal found in urine from male prairie voles to induce uterine growth necessary for reproduction. Urine from male mice (Mus musculus) does not contain an effective cue for activation of female vole reproduction: after 4 days of exposure to stimuli, voles exposed to urine from female or water had still uteri whereas voles exposed to urine from male voles had large uteri. The initial response to urine from male voles included neuronal activity in the vomeronasal system as indicated by FOS immunocytochemistry. Stimuli (urine from a male vole or a male mouse, or water) were painted on the nose of naive female voles 1 h before sacrifice. Female voles exposed to urine from male voles had more FOS-immunoreactive cells in the accessory olfactory bulb than voles exposed to mouse urine or to water. We conclude that exposure to urine from male voles stimulates the vomeronasal pathway (as measured by FOS immunoreactivity) and induces uterine growth in female voles, whereas exposure to urine from male mice (or water) does not. This suggests that some degree of functional specificity of the clinical cue is determined at or before the accessory olfactory bulb, perhaps in the expression of specific receptors within the vomeronasal organ, rather than entirely within the central nervous system.
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Induction of uterine growth and estrus in female prairie voles normally resulting from exposure to males is dependent on an intact VNO.
“Induction of uterine growth and estrus in female prairie voles normally resulting from exposure to males is also dependent on an intact VNO (Tubbiola and Wysocki, 1997).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Tubbiola and Wysocki, 1997
Cites
Expression of c- <i>fos</i> Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925 · see citing works
Carter, C. S., Getz, L. L., Gavish, L., Dermott, J. L. M., & Arnold, P. (1980) · Biology of Reproduction · doi:10.1095/biolreprod23.5.1038 · Cited by 242 · see citing works
Vomeronasal organ removal before sexual experience impairs male hamster mating behavior.
Meredith, M. (1986) · Physiology and Behavior · doi:10.1016/0031-9384(86)90362-8 · Cited by 186 · see citing works
CARTER, C. (1987) · Hormones and Behavior · doi:10.1016/0018-506x(87)90032-8 · Cited by 130 · see citing works
Brennan, P., Hancock, D. C., & Keverne, E. B. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90095-j · Cited by 129 · see citing works
Pheromones induce c-fos in limbic areas regulating male hamster mating behavior
Fiber, J. M., Adames, P., & Swann, J. M. (1993) · Neuroreport · doi:10.1097/00001756-199307000-00008 · Cited by 113 · see citing works
Dudley, C. A., Rajendren, G. V., & Moss, R. L. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90034-y · Cited by 65 · see citing works
Removal of the vomeronasal organ disrupts the activation of reproduction in female voles.
Lepri, J., & Wysocki, C. (1987) · Physiology and Behavior · doi:10.1016/0031-9384(87)90058-8 · Cited by 65 · see citing works
Self-citationSchellinck, H. M., Smyth, C. E., Brown, R. E., & Wilkinson, M. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90094-q · Cited by 48 · see citing works
Effect of pheromones from male goats on LH-secretion in anoestrous ewes
Over, R., Cohen-Tannoudji, J., Dehnhard, M., Claus, R., & Signoret, J. P. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90208-l · Cited by 47 · see citing works
Wysocki, C. J., Kruczek, M., Wysocki, L., & Lepri, J. J. (1991) · Biology of Reproduction · doi:10.1095/biolreprod45.4.611 · Cited by 37 · see citing works
Self-citationThe effects of photoperiod on olfactory c-fos expression in prairie voles,Microtus ochrogaster
Moffatt, C. A., Ball, G. F., & Nelson, R. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00125-a · Cited by 22 · see citing works
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Structure and function of the vomeronasal system: an update
Halpern, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00103-5 · Cited by 639 · see citing works
Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases
Meredith, M. (2001) · Chemical Senses · doi:10.1093/chemse/26.4.433 · Cited by 280 · see citing works
Gobrogge, K. L., Liu, Y., Jia, X., & Wang, Z. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21364 · Cited by 178 · see citing works
Kelliher, K. R., Chang, Y., Wersinger, S. R., & Baum, M. J. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.6.1454 · Cited by 97 · see citing works
Curtis, J. T., Liu, Y., & Wang, Z. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02343-5 · Cited by 78 · see citing works
Cohabitation induced Fos immunoreactivity in the monogamous prairie vole
Cushing, B. S., Mogekwu, N. I., Le, W., Hoffman, G. E., & Carter, C. S. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04199-9 · Cited by 74 · see citing works
Dudley, C. A., & Moss, R. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00711-8 · Cited by 63 · see citing works
Neural pathways involved in the endocrine response of anestrous ewes to the male or its odor
Gelez, H., & Fabre‐Nys, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.066 · Cited by 61 · see citing works
Inamura, K., Kashiwayanagi, M., & Kurihara, K. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00646.x · Cited by 48 · see citing works
Anand, S., Losee-Olson, S. H., Turek, F. W., & Horton, T. H. (2002) · Endocrinology · doi:10.1210/endo.143.6.8839 · Cited by 39 · see citing works
Matsuoka, M., Yokosuka, M., Mori, Y., & Ichikawa, M. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00082-6 · Cited by 27 · see citing works
Genetics of Aggression in Voles
Gobrogge, K. L., & Wang, Z. (2011) · Advances in genetics · doi:10.1016/b978-0-12-380858-5.00003-4 · Cited by 26 · see citing works
Gouat, P., Patris, B., & Lalande, C. (1998) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(98)80459-9 · Cited by 20 · see citing works
delBarco‐Trillo, J., Gulewicz, K., & Johnston, R. E. (2009) · Behavioral Neuroscience · doi:10.1037/a0016439 · Cited by 19 · see citing works
Chun, E. K., Donovan, M., Liu, Y., & Wang, Z. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100427 · Cited by 18 · see citing works
Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles
Gobrogge, K. L. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_264 · Cited by 16 · see citing works
Hairston, J. E., Ball, G. F., & Nelson, R. J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00963.x · Cited by 15 · see citing works
Katz, L. F., Ball, G. F., & Nelson, R. J. (1999) · Cell and Tissue Research · doi:10.1007/s004419900123 · Cited by 14 · see citing works
Maslak, S., & Gouat, P. (2002) · Journal of comparative psychology · doi:10.1037//0735-7036.116.4.357 · Cited by 12 · see citing works
The Female Pheromone 2,5-Dimethylpyrazine Induces Sperm-Head Abnormalities in Male CBA Mice
Даев, Е. В., & Dukelskaya, A. V. (2003) · Russian Journal of Genetics · doi:10.1023/a:1024709321888 · Cited by 10 · see citing works
Akiba, Y., Sasaki, H., Saino‐Saito, S., & Baker, H. A. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9134-7 · Cited by 9 · see citing works
Chapter V Molecular activity maps of sensory function
Chaudhuri, A., & Zangenehpour, S. (2002) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(02)80016-1 · Cited by 5 · see citing works
Lang, D.-L. Y., Bamshad, M., & Dorcely, R. (2019) · Brain Research · doi:10.1016/j.brainres.2019.02.023 · Cited by 4 · see citing works
Даев, Е. В., & Ol, S. (2002) · Russian Journal of Genetics · doi:10.1023/a:1014325809325 · Cited by 3 · see citing works
Tai, F., Broders, H. G., Lian, Y., Wang, T. Z., & Sun, R. Y. (2006) · Canadian Journal of Zoology · doi:10.1139/z06-104 · Cited by 1 · see citing works
- Authors
- Tubbiola, M. L., & Wysocki, C. J.
- Affiliations
- Monell Chemical Senses Center (US)
- Corresponding author
- Tubbiola, M.L
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 62
- Issue
- 4
- Pages
- 867-870
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W181190896
- Cited by
- 25
- References
- 12
- Citations by year
- 2022: 1 · 2019: 1 · 2013: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (DC00014)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- Microtus ochrogaster, vomeronasal system, accessory olfactory bulb, Fos-like immunoreactivity, uterine growth, female reproduction, vomeronasal receptors, vomeronasal organ
- MeSH terms
- Animals, Arvicolinae, Cues, Female, Immunohistochemistry, Male, Smell, Urine, Uterus, Proto-Oncogene Proteins c-fos, Mice
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