Daily Activity and Body Temperature Rhythms Do Not Change Simultaneously With Age in Laboratory Mice
Abstract
Daily rhythms of locomotor activity (AR) and body temperature (TR) were investigated in juvenile, adult, and senile female laboratory mice (5, 16, or 65 weeks old). All daily patterns were bimodal, with a main maximum in the dark and a secondary one immediately following lights on. The juvenile mice showed the highest magnitude of oscillation of the AR but the lowest magnitude of the TR; the magnitudes of the TR of adult and senile animals were not different, whereas those of AR in senile mice approached zero. For the AR, but not the TR, a phase advance with age was observed. The effect of locomotor activity on the body temperature was higher during the light time (minimum of motor activity) than during the dark time (maximum activity), and was least in juvenile mice. The calculated daily temperatures corresponding to zero activity gave rhythms that showed no age-dependent differences in daily mean or magnitude. This implies that the age-dependent changes of the TR were due mainly to masking effects.
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For pubertal mice, the tendency to be more responsive to light at subjective night was exaggerated, with the animals being clearly more sensitive to evening light than adults.
“For pubertal mice, this tendency was exaggerated, with the animals being clearly more sensitive to evening light than adults [70, 198].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [198]
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- Authors
- Weinert, D., & Waterhouse, J.
- Affiliations
- Martin Luther University Halle-Wittenberg (DE)
- Liverpool John Moores University (GB)
- Corresponding author
- Weinert, D
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 66
- Issue
- 4
- Pages
- 605-612
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1970458326
- Cited by
- 78
- References
- 29
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- circadian rhythm, locomotor activity, body temperature, aging, age-related changes, masking, phase advance, juvenile mice, light-dark cycle
- MeSH terms
- Aging, Animals, Body Temperature, Circadian Rhythm, Female, Mice, Inbred ICR, Motor Activity, Reference Values, Mice
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