The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Improvement in Mood, Physical Symptoms, and Function With Nortriptyline for Depression in Patients With Chronic Obstructive Pulmonary Disease
Abstract
Although recent epidemiologic studies have established that patients with chronic medical illness and depressed mood are more disabled than euthymic patients, detailed data on the benefits and risks of antidepressant treatment in medically high-risk patients have been slow to accumulate. The authors have examined multiple outcome indicators in patients with disabling chronic obstructive pulmonary disease and comorbid depression. Thirty patients completed a 12-week, randomized controlled trial of nortriptyline. Nortriptyline was clearly superior to placebo for treatment of depression. Nortriptyline treatment was accompanied by marked improvements in anxiety, certain respiratory symptoms, overall physical comfort, and day-to-day function; placebo effects were negligible. Physiological measures reflecting pulmonary insufficiency were generally unaffected by treatment. These data provide impetus for renewed efforts to improve recognition and treatment of mood disorders in even severely disabled medical patients.
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In the citing paper
“Depression has been found to predict fatigue, shortness of breath, and disability in patients with heart disease or COPD, even after adjusting for severity of illness.52–56”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“Evidence for antidepressant therapy in COPD is limited, with only one small, randomized, placebo-controlled trial53 of treatment in patients with major depression having been published.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“This study found high efficacy for nortriptyline, a tricyclic antidepressant, in improving short-term outcomes for depression, anxiety, panic attacks, cognitive function, and overall disability.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
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Metadata
- Authors
- Borson, S., McDonald, G. J., Gayle, T., Deffebach, M., Lakshminarayan, S., & VanTuinen, C.
- Affiliations
- University of Washington (US)
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 33
- Issue
- 2
- Pages
- 190-201
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2040089352
- Cited by
- 277
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- nortriptyline, depression, chronic obstructive pulmonary disease, antidepressant treatment, comorbid depression, mood improvement, somatic symptoms, functional capacity, anxiety, pulmonary insufficiency, placebo effect, severely disabled patients
- MeSH terms
- Activities of Daily Living, Affect, Attitude to Health, Chronic Disease, Depressive Disorder, Dyspnea, Female, Humans, Lung Diseases, Obstructive, Male, Middle Aged, Nortriptyline, Patient Compliance, Placebos, Prednisone, Psychiatric Status Rating Scales
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