The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Improvement in Mood, Physical Symptoms, and Function With Nortriptyline for Depression in Patients With Chronic Obstructive Pulmonary Disease
Abstract
Although recent epidemiologic studies have established that patients with chronic medical illness and depressed mood are more disabled than euthymic patients, detailed data on the benefits and risks of antidepressant treatment in medically high-risk patients have been slow to accumulate. The authors have examined multiple outcome indicators in patients with disabling chronic obstructive pulmonary disease and comorbid depression. Thirty patients completed a 12-week, randomized controlled trial of nortriptyline. Nortriptyline was clearly superior to placebo for treatment of depression. Nortriptyline treatment was accompanied by marked improvements in anxiety, certain respiratory symptoms, overall physical comfort, and day-to-day function; placebo effects were negligible. Physiological measures reflecting pulmonary insufficiency were generally unaffected by treatment. These data provide impetus for renewed efforts to improve recognition and treatment of mood disorders in even severely disabled medical patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Depression has been found to predict fatigue, shortness of breath, and disability in patients with heart disease or COPD, even after adjusting for severity of illness.52–56”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“Evidence for antidepressant therapy in COPD is limited, with only one small, randomized, placebo-controlled trial53 of treatment in patients with major depression having been published.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
In the citing paper
“This study found high efficacy for nortriptyline, a tricyclic antidepressant, in improving short-term outcomes for depression, anxiety, panic attacks, cognitive function, and overall disability.”
From Anxiety and Depression in COPD (2008) · cites this paper as [53]
Citations
Cites
The Sickness Impact Profile: Development and Final Revision of a Health Status Measure
Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981) · Medical Care · doi:10.1097/00005650-198108000-00001 · Cited by 4,619
The functioning and well-being of depressed patients. Results from the Medical Outcomes Study
Wells, K. B. (1989) · JAMA · doi:10.1001/jama.262.7.914 · Cited by 2,826
Functional Status and Well-being of Patients With Chronic Conditions
Stewart, A. L. (1989) · JAMA · doi:10.1001/jama.1989.03430070055030 · Cited by 2,309
The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study
Wells, K. B. (1989) · JAMA · doi:10.1001/jama.1989.03430070062031 · Cited by 2,130
Stewart, A. L. (1989) · JAMA · doi:10.1001/jama.262.7.907 · Cited by 2,095
Somatization: the concept and its clinical application
(1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.11.1358 · Cited by 1,079
Sheehan, D. V. (1984) · Medical Entomology and Zoology · Cited by 883
Twelve-minute walking test for assessing disability in chronic bronchitis.
McGavin, C. R., Gupta, S., & McHardy, G. J. R. (1976) · BMJ · doi:10.1136/bmj.1.6013.822 · Cited by 746
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey, J. R., Pearlson, G., Robinson, R. G., Rao, K. C. V. G., & Price, T. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90356-8 · Cited by 536
Somatic presentation of DSM-III psychiatric disorders in primary care
Bridges, K. W., & Goldberg, D. P. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90064-9 · Cited by 534
Research works printed but not linked: 1
- Lareau, 1986, Functional levels and dyspnea in patients with COPD (abstract), Am Rev Respir Dis, 133, A163
Cited by
Sorted by citations
Items 101–200 of 276
Current Dyspnea Among Long-Term Survivors of Early-Stage Non-small Cell Lung Cancer
Feinstein, M. B., Krebs, P., Coups, E. J., Park, B. J., Steingart, R. M., Burkhalter, J., Logue, A., & Ostroff, J. S. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181df61c8 · Cited by 56
Depression in COPD ? management and quality of life considerations
Stage, K. B., Middelboe, T., Stage, T. B., & Sørensen, C. H. (2006) · International Journal of COPD · doi:10.2147/copd.2006.1.3.315 · Cited by 59
“International Journal of COPD 2006:1(3) 317 Treatment of depression in COPD patients Antidepressants The tricyclic antidepressants (TCAs) have been tested in a few studies (Light et al 1986; Sharma et al 1988; Borson et al 1992).”
BackgroundPollok, J., van Agteren, J. E., & Carson-Chahhoud, K. V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012346.pub2 · Cited by 59
“In the study by Borson 1992, four participants in each group (31% of treatment and 24% of placebo participants) required continuous home oxygen.”
BackgroundMethodResultInfluentialYohannes, A. M., & Alexopoulos, G. S. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0186-0 · Cited by 57
“A double-blind, placebo-controlled trial [32] examined the efficacy of nortriptyline therapy for 12 weeks in COPD patients with major depression, confirmed by psychiatrists using the Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III) structured clinical interview for depression.”
BackgroundMethodUsmani, Z. A., Carson, K. V., Cheng, J. N., Esterman, A. J., & Smith, B. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008483.pub2 · Cited by 57
Outcomes of depressed patients undergoing inpatient pulmonary rehabilitation
Alexopoulos, G. S., Sirey, J. A., Raue, P. J., Kanellopoulos, D., Clark, T. E., & Novitch, R. S. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000199381.98971.d1 · Cited by 57
A Symptom-Based Measure of the Severity of Chronic Lung Disease
Selim, A. J., Fincke, B. G., Ren, X. S., Rogers, W. H., Lee, A. F., & Kazis, L. E. (1997) · CHEST Journal · doi:10.1378/chest.111.6.1607 · Cited by 56
Multidisciplinary Care of the Patient with Chronic Obstructive Pulmonary Disease
Kuzma, A. M., Meli, Y. M., Meldrum, C., Jellen, P. A., Butler-Lebair, M., Koczen-Doyle, D., Rising, P., Stavrolakes, K., & Brogan, F. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-125et · Cited by 59
“Psychopharmacology (6) and pulmonary rehabilitation (7, 8) also seem to be promising treatments (9) for depression and anxiety in COPD.”
BackgroundDrug Treatment of Depression in Frail Elderly Nursing Home Residents
Streim, J. E., Oslin, D. W., Katz, I. R., Smith, B. D., DiFilippo, S. D., Cooper, T. B., & Have, T. T. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200005000-00010 · Cited by 55
Communication about Palliative Care for Patients with Chronic Obstructive Pulmonary Disease
Curtis, J. R., Engelberg, R. A., Wenrich, M. D., & Au, D. H. (2005) · Journal of Palliative Care · doi:10.1177/082585970502100308 · Cited by 53
Depression Associated with Medical Illness: Treatment Considerations
Fava, G. A., & Sonino, N. (1996) · CNS Drugs · doi:10.2165/00023210-199605030-00004 · Cited by 53
Qian, J., Simoni‐Wastila, L., Rattinger, G. B., Zuckerman, I. H., Lehmann, S. W., Wei, Y. J., & Stuart, B. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3968 · Cited by 50
Current Perspectives on Management of Co-Morbid Depression in COPD
Norwood, R. J., & Balkissoon, R. (2005) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200050740 · Cited by 51
“(35) demonstrated that antidepressant medication was effective in reducing depression; all the other studies were inconclusive.”
BackgroundResultUse of Health Services by Medically Ill Depressed Elderly Patients After Hospital Discharge
Koenig, H. G., & Kuchibhatla, M. N. (1999) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199902000-00007 · Cited by 51
Depressive symptoms and measures of disability: a prospective study
Katon, W. J., Sullivan, M. D., Russo, J. E., Dobie, R. A., & Sakai, C. S. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90048-o · Cited by 49
“Moreover, treatment studies of patients with major depression and co-morbid medical illness have demonstrated significant decreases in measures of depression and functional disability in patients treated with antidepressants versus those treated with placebo (Sullivan et al., in press; Borson et al., 1992).”
BackgroundDeveloping an intervention for depressed, chronically medically ill elders: A model from COPD
Alexopoulos, G. S., Raue, P. J., Sirey, J. A., & Arean, P. A. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1925 · Cited by 48
“symptoms, physical comfort, and day-to day function (Borson et al., 1992).”
BackgroundMajor Depression in Medically III Patients
Sutor, B., Rummans, T. A., Jowsey‐Gregoire, S. G., Krahn, L. E., Martin, M. J., O'Connor, M. K., Philbrick, K. L., & Richardson, J. W. (1998) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)63698-7 · Cited by 47
Kayahan, B., Karapolat, H., Atýntoprak, E., Atasever, A., & Öztürk, Ö. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.09.031 · Cited by 46
The Future of Psychosocial Treatments for Elderly Patients
Klausner, E. J., & Alexopoulos, G. S. (1999) · Psychiatric Services · doi:10.1176/ps.50.9.1198 · Cited by 46
Simon, N. M., Weiss, A. M., Kradin, R., Evans, K. C., Reese, H. E., Otto, M. W., Oppenheimer, J. E., Smoller, J. W., Zalta, A., Worthington, J. J., et al. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000249062.25829.53 · Cited by 43
“Table 1 presents the characteristics of patients with PFT findings consistent with COPD, any other pulmonary dysfunction, or no dysfunction in terms of rates of anxiety disorders, ASI score, subjective severity of dyspnea, and avoidance due to dyspnea.”
BackgroundInfluentialNguyen, H. Q., & Carrieri‐Kohlman, V. (2005) · Psychosomatics · doi:10.1176/appi.psy.46.5.402 · Cited by 43
Depression and suicidality in COPD: understandable reaction or independent disorders?
Hegerl, U., & Mergl, R. (2014) · European Respiratory Journal · doi:10.1183/09031936.00193213 · Cited by 43
Wagena, E. J., Zeegers, M. P., van Schayck, O. C. P., & Wouters, E. F. �. (2003) · Drug Safety · doi:10.2165/00002018-200326060-00002 · Cited by 42
Subjective health measures and acute treatment outcomes in geriatric depression
Lenze, E. J., Miller, M. D., Dew, M. A., Martire, L. M., Mulsant, B. H., Begley, A. E., Schulz, R., Frank, E., & Reynolds, C. F. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.503 · Cited by 41
BRUCE, M. L. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47178-7_2 · Cited by 41
“This approach has been seen more frequently in recent years with a growing number of clinical trials for depression, including functional outcomes (Borson et al., 1992; Heiligenstin et al., 1995; Mazumdar et al., 1996; Small et al., 1996).”
BackgroundModels of Care for Late-Life Depression of the Medically Ill: Examples from COPD and Stroke
Avari, J. N., & Alexopoulos, G. (2014) · The American journal of geriatric psychiatry · doi:10.1016/j.jagp.2014.06.004 · Cited by 17
Disler, R. T., Currow, D. C., Phillips, J. L., Smith, T., Johnson, M. J., & Davidson, P. M. (2012) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2012.02.004 · Cited by 43
Panic, hyperventilation and perpetuation of anxiety
Dratcu, L. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00130-5 · Cited by 39
The systematic assessment of depressed elderly primary care patients
Raue, P. J., Alexopoulos, G. S., BRUCE, M. L., Klimstra, S., Mulsant, B. H., Gallo, J. J., & the PROSPECT Study Group (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.469 · Cited by 39
Anxiety, Depression, and Cognitive Impairment in Patients with Chronic Respiratory Disease
Fan, V. S., & Meek, P. (2014) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2014.02.012 · Cited by 38
End-of-life care in COPD: A survey carried out with Portuguese Pulmonologists
Gaspar, C., Alfarroba, S., Telo, L., Gomes, C., & Bárbara, C. (2014) · Revista Portuguesa de Pneumologia · doi:10.1016/j.rppnen.2014.01.005 · Cited by 38
“We found a better performance, which may reveal a rising awareness of the beneficial effects of antidepressants in improving mood and decreasing dyspnoea in COPD patients.(13) Treating depression is essential since it may modify patient decisions concerning EoL care.”
BackgroundInterventions for depressed elderly primary care patients
Alexopoulos, G. S., & the PROSPECT Group (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.464 · Cited by 38
Depression and COPD in older people: a review and discussion
Yohannes, A. M. (2005) · British Journal of Community Nursing · doi:10.12968/bjcn.2005.10.1.17335 · Cited by 37
Late‐life suicide and depression in the primary care setting
Pearson, J. L., Conwell, Y., & Lyness, J. M. (1997) · New Directions for Mental Health Services · doi:10.1002/yd.2330247604 · Cited by 37
Management of anxiety and depression in patients with COPD
Yohannes, A. M. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.3.337 · Cited by 36
Cohen‐Cole, S. A., & Kaufman, K. G. (1993) · Depression · doi:10.1002/depr.3050010402 · Cited by 36
A validation study of The Geriatric Depression Scale short form
Herrmann, N., Mittmann, N., Silver, I., Shulman, K. I., Busto, U. E., Shear, N. H., & Naranjo, C. A. (1996) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199605)11:5 · Cited by 194
Felker, B. L., Bush, K. R., Harel, O., Shofer, J. B., Shores, M. M., & Au, D. H. (2010) · The Primary Care Companion to The Journal of Clinical Psychiatry · doi:10.4088/pcc.09m00858gry · Cited by 35
Wagena, E. J., Huibers, M. J. H., & van Schayck, O. C. P. (2001) · Thorax · doi:10.1136/thorax.56.8.587a · Cited by 36
Influence de l’anxiété et de la dépression sur les exacerbations au cours de la BPCO
Underner, M., Cuvelier, A., Peiffer, G., Perriot, J., & Jaafari, N. (2018) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2018.04.004 · Cited by 43
Weber, C., Stirnemann, J., Herrmann, F. R., Pautex, S., & Janssens, J.-P. (2014) · BMC Palliative Care · doi:10.1186/1472-684x-13-47 · Cited by 32
“Antidepressants can significantly improve mood among patients with COPD and depression [23].”
BackgroundHealth Status Measurement Instruments in Chronic Obstructive Pulmonary Disease
Lacasse, Y., Wong, E. Y. L., Guyatt, G. H., & Goldstein, R. S. (1997) · Canadian Respiratory Journal · doi:10.1155/1997/219618 · Cited by 33
Psychiatric Considerations in Pulmonary Disease
Shanmugam, G., Bhutani, S., Khan, D. A., & Brown, E. S. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2007.07.008 · Cited by 30
Chronic Medical Illness in Patients With Recurrent Major Depression
Miller, M. D., Paradis, C. F., Houck, P. R., Rifai, A. H., Mazumdar, S., Pollock, B. G., Perel, J. M., Frank, E., & Reynolds, C. F. (1996) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199622440-00002 · Cited by 30
Suh, S., Ellis, R. J., Sollers, J. J., Thayer, J. F., Yang, H.-C., & Emery, C. F. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.02.007 · Cited by 28
“Additionally, patients with both chronic medical illness and comorbid mental illness are more functionally disabled than patients who have either a chronic medical illness or a mental illness alone, and past research has revealed a relationship between psychiatric comorbidity and functional status among patients with…”
Bessette, K. L., Karstens, A. J., Crane, N. A., Peters, A. T., Stange, J. P., Elverman, K. H., Morimoto, S. S., Weisenbach, S. L., & Langenecker, S. A. (2020) · Neuropsychology Review · doi:10.1007/s11065-019-09424-5 · Cited by 33
Effect of Depression Care on Outcomes in COPD Patients With Depression
Jordan, N., Lee, T. A., Valenstein, M. M., Pirraglia, P. A., & Weiss, K. B. (2008) · CHEST Journal · doi:10.1378/chest.08-0839 · Cited by 30
Recomendaciones sobre la atención al final de la vida en pacientes con EPOC
Escarrabill, J., Soler‐Cataluña, J. J., Hernández, C., & Servera, E. (2009) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2008.11.005 · Cited by 29
Moretta, P., Cavallo, N. D., Candia, C., Lanzillo, A., Marcuccio, G., Santangelo, G., Marcuccio, L., Ambrosino, P., & Maniscalco, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216418 · Cited by 36
“Tricyclic antidepressants (TCAs) have also been used in COPD patients for the treat-ment of depression [109], but their role in clinical practice is limited by the reported elevated incidence of side effects, mainly cardiovascular and anticholinergic [110].”
Qian, J., Simoni‐Wastila, L., LANGENBERG, P. W., Rattinger, G. B., Zuckerman, I. H., Lehmann, S. W., & Terrin, M. C. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12220 · Cited by 29
Self-reported Depressive Symptoms in Myasthenia Gravis
Fisher, J. R., Parkinson, K., & Kothari, M. J. (2003) · Journal of Clinical Neuromuscular Disease · doi:10.1097/00131402-200303000-00001 · Cited by 28
Mishima, M., Oku, Y., Muro, S., Hirai, T., Chin, K., Ohi, M., Nakagawa, M., FUJITA, M., Sato, K., Shimada, K., et al. (1996) · Internal Medicine · doi:10.2169/internalmedicine.35.453 · Cited by 28
Panic, Anxiety, and Chronic Dyspnea
Periyakoil, V. S., Skultety, K. M., & Sheikh, J. I. (2005) · Journal of Palliative Medicine · doi:10.1089/jpm.2005.8.453 · Cited by 27
Anxiety and depression in chronic obstructive pulmonary disease: A new intervention and case report
Stanley, M. A., Veazey, C. H., Hopko, D. R., Diefenbach, G. J., & Kunik, M. E. (2005) · Cognitive and Behavioral Practice · doi:10.1016/s1077-7229(05)80070-7 · Cited by 26
Hansen-Flaschen, J. H. (1997) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70407-x · Cited by 27
“ery to functional independence, and (4) indefinite life support so long as the patient”
BackgroundPumar, M., Roll, M., Fung, P., Rolls, T., Walsh, J., Bowman, R., Fong, K. M., & Yang, I. A. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.23 · Cited by 25
Antidepressiva zur Behandlung der Depression bei Palliativpatienten
Ujeyl, M., & Müller-Oerlinghausen, B. (2012) · Der Schmerz · doi:10.1007/s00482-012-1221-x · Cited by 26
Yohannes, A. M., & Connolly, M. J. (2011) · Expert Review of Respiratory Medicine · doi:10.1586/ers.11.70 · Cited by 25
Treating COPD in Older and Oldest Old Patients
Corsonello, A., Scarlata, S., Pedone, C., Bustacchini, S., Fusco, S., Zito, A., & Incalzi, R. A. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150130121229 · Cited by 24
“Finally, a small RCT of patients with COPD showed that nortriptyline was better than placebo for treatment of depression, anxiety, and panic attacks in patients with COPD [154].”
BackgroundManagement of refractory breathlessness in patients with advanced cancer
Simon, S. T., & Bausewein, C. (2009) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-009-0728-y · Cited by 24
“with placebo is still recruiting and this study will hopefully bring further information about the efficacy of buspirone in the relief of breathlessness [43].”
BackgroundExamining the Link between Sarcoidosis and Depression
Curtis, J. R., & Borson, S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.ed2000b · Cited by 23
Self-citationThe Context of Depression in Latinos in the United States
Aguilar‐Gaxiola, S., Kramer, E. J., Resendez, C. I., & Magaña, C. G. (2008) · Issues in children's and families' lives · doi:10.1007/978-0-387-78512-7_1 · Cited by 23
“Moreover, depression and depressive affect have a significant negative effect on symptom burden, functional impairment, and disease management (Borson et al., 1992; Fann, Katon, Uomoto, & Esselman, 1995; Lustman, Clouse, & Freedland, 1998).”
BackgroundJournal impact factors for 2000: Thorax flying yet higher
Knox, A. J., & BRITTON, J. (2001) · Thorax · doi:10.1136/thorax.56.8.587 · Cited by 29
Differences Between Depressed Patients With Heart Failure and Those With Pulmonary Disease
Koenig, H. G. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000192495.73673.3e · Cited by 21
Use of Antidepressants in Older Patients with Co-Morbid Medical Conditions
Kennedy, G. J., & Marcus, P. (2005) · Drugs & Aging · doi:10.2165/00002512-200522040-00001 · Cited by 20
“[40] Moreover, respiratory symptoms, crease in the risk of depression compared with other physical comfort and daily function also improved.”
BackgroundHong, Y. J., Kim, Y., Moon, J., Park, S., Lee, J., Jung, K., Yoo, K. H., Kim, Y., & Choi, J. Y. (2023) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666231216591 · Cited by 18
“48,49 In addition, some studies have shown the importance of pulmonary rehabilitation in depressed and anxious COPD patients.”
BackgroundQian, J., Simoni, J. M., Rattinger, G. B., Lehmann, S. W., LANGENBERG, P. W., Zuckerman, I. H., & Terrin, M. C. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.06.005 · Cited by 19
“Growing evidence suggests that antidepressant medications may be effective in treating depression and depressive symptoms for COPD patients [27–30]; however, little is known about the associations of depression and antidepressant treatment on COPD outcomes for Medicare beneficiaries younger than 65 years.”
BackgroundAnxiety in medically III patients
Mago, R., Gomez, J.-P., Gupta, N., & Kunkel, E. J. S. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0028-9 · Cited by 19
Ruffin, R. E., Wilson, D. H., Chittleborough, C., Southcott, A., Smith, B., & Christopher, D. J. (2000) · Quality of Life Research · doi:10.1023/a:1016689729722 · Cited by 19
“It is possible that symptomatic treatment already identi®ed in the literature [11, 15] could have a marked eect on the mental health sub scales in Figure 1 improving further the overall quality of life of CLD patients.”
BackgroundMood disorders and chronic obstructive pulmonary disease: Current research and future needs
Clary, G. L., Palmer, S. M., & Doraiswamy, P. M. (2002) · Current Psychiatry Reports · doi:10.1007/s11920-002-0032-7 · Cited by 17
Anxiety and Depression in COPD: A Call (and Need) for Further Research
Wamboldt, F. S. (2005) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200058288 · Cited by 17
Major Depression and Physical Illness Trajectories in Heart Failure and Pulmonary Disease
Koenig, H. G., Johnson, J. L., & Peterson, B. L. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000249107.26884.72 · Cited by 16
“Finally, antidepressant drug treatments and psychosocial interventions can reduce the negative consequences of depression (Benatar et al., 2003; Borson et al., 1992), although this is not without controversy (Berkman et al.”
BackgroundPredictors of depression outcomes in medical inpatients with chronic pulmonary disease
Koenig, H. G. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000206380.57732.54 · Cited by 17
Palliation of chronic obstructive pulmonary disease.
Lal, A. A., & Case, A. A. (2014) · PubMed · doi:10.3978/j.issn.2224-5820.2014.10.03 · Cited by 16
“Anxiolytics have not been shown to benefit in the pathogenesis of dyspnea, however, help in anxiety which can perpetuate dyspnea (61).”
BackgroundFritzsche, A., Watz, H., MAGNUSSEN, H., Tuinmann, G., Löwe, B., & von Leupoldt, A. (2013) · British Journal of Health Psychology · doi:10.1111/bjhp.12025 · Cited by 16
La bronchopneumopathie chronique obstructive (BPCO) du sujet âgé en huit questions/réponses
Orvoën-Frija, E., Benoît, M., Catto, M., Chambouleyron, M., Duguet, A., Émeriau, J. P., Ferry, M., Hayot, M., Jeandel, C., Morize, V., et al. (2010) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2010.08.005 · Cited by 15
Depression in Patients with Chronic Obstructive Pulmonary Disease
Garvey, C. M. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.05.2553 · Cited by 15
The effectiveness of the treatment of depression in the physically ill elderly
Draper, B. (2000) · Aging & Mental Health · doi:10.1080/13607860055928 · Cited by 15
Traumatic brain injury and psychiatry
Fann, J. R. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00130-x · Cited by 15
Antidepressants in Rehabilitation
Teasell, R. W., Merskey, H., & Deshpande, S. (1999) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/s1047-9651(18)30195-5 · Cited by 15
Impact of Treating Depression on Associated Comorbidities
Arnaud, A. M., Brister, T. S., Duckworth, K., Foxworth, P. M., Fulwider, T., Suthoff, E. D., WERNEBURG, B. G., Aleksanderek, I., & Reinhart, M. L. (2022) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.22r03330 · Cited by 19
Loprinzi, P. D., Kane, C., & Walker, J. F. (2013) · Preventive Medicine · doi:10.1016/j.ypmed.2013.07.009 · Cited by 14
“Antidepressants ameliorate depression symptoms in some but not all cases (Borson et al., 1992).”
BackgroundNon-opioid medications for the relief of chronic breathlessness: current evidence
Barbetta, C., Currow, D. C., & Johnson, M. J. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1305896 · Cited by 14
“Borson, 1992 [26] RCT Nortriptyline 30 COPD n.”
Effect of treatment of depression and anxiety on physiological state of severe COPD patients
Momtaz, O. M., Rabei, S. M., Tawfike, N. R., & Hasan, A. (2014) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2014.08.006 · Cited by 14
Schünemann, H. J., Guyatt, G. H., Griffith, L. E., Stubbing, D. G., & Goldstein, R. S. (2002) · CHEST Journal · doi:10.1378/chest.122.5.1701 · Cited by 14
Réhabilitation du patient atteint de BPCO
(2010) · Revue des Maladies Respiratoires · doi:10.1016/s0761-8425(10)70005-x · Cited by 14
The Public Health Model for Mental Health Care for the Elderly
Katz, I. R. (2000) · JAMA · doi:10.1001/jama.283.21.2844 · Cited by 14
Kozer, E., Levichek, Z., Hoshino, N., Kapur, B. M., Leombruno, J., Taguchi, N., García‐Bournissen, F., Koren, G., & Ito, S. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31817e6e53 · Cited by 13
“In overdose, TCAs can cause pulmonary edema.(23) In therapeutic doses tricyclic antidepressants induced depression of the respiratory drive in a patient with COPD and a psychiatric disorder(10) and were associated with a significant reduction in CO2 sensitivity.”
BackgroundResultNaqvi, S. S., Pollok, J., van Agteren, J. E., Usmani, Z. A., Carson‐Chahhoud, K., Smith, B. J., & Licinio, J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012346 · Cited by 14
Pirraglia, P. A., Charbonneau, A., Kader, B., & Berlowitz, D. R. (2006) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v08n0203 · Cited by 13
“Antidepressants have also been shown to be effective for treating depression in patients with COPD.(18,19) Antidepressant prescribing is increasing in primary care,(20) and some antidepressant agents may even have effects beyond their primary indication, such as reducing symptoms of dyspnea in patients with COPD.”
BackgroundNeurobehavioral Correlates of Chronic Hepatitis C
Hilsabeck, R. C., & Malek-Ahmadi, P. (2004) · Journal of Psychopathology and Behavioral Assessment · doi:10.1023/b:joba.0000022113.60976.4a · Cited by 12
Integrated management strategies for chronic obstructive pulmonary disease
Adams, S. (2010) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s8173 · Cited by 10
“, feeling easily exhausted or suffocated), and overall disability.(53) In a study of cognitive behavioral therapy (CBT), a single intensive two-hour session resulted in a significant improvement in depressive and anxiety symptoms relative to education only.”
Neuropsychiatric Aspects of Failure to Thrive in Late Life
Katz, I. R., & DiFilippo, S. D. (1997) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30140-x · Cited by 11
Monoaminergic‐based Pharmacotherapy for Depression
Papakostas, G. I., & D, M. F. M. (2005) · Wiley eBooks · doi:10.1002/9783527619672.ch6 · Cited by 11
Slatore, C. G., Falvo, M. J., Nugent, S. M., & Carlson, K. F. (2018) · Military Medicine · doi:10.1093/milmed/usx108 · Cited by 10
Depression Comorbidity With COPD
Alexopoulos, G. S., & Latoussakis, V. (2004) · Psychiatric Annals · doi:10.3928/0048-5713-20040401-09 · Cited by 10
Chronic Obstructive Pulmonary Disease in the Older Patient
Nazir, S. A., Alhamed, M., & Erbland, M. L. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2007.07.003 · Cited by 10
Palliative Home Care for Advanced Lung Disease
Hansen-Flaschen, J. H. (2000) · Respiratory Care · doi:10.1177/002013240004501204 · Cited by 10
Complex Neurobehavioral Testing of a Rat Model of the Irritable Bowel Syndrome
Lefter, R. M., Ciobica, A. S., Guenné, S., Compaoré, M., Kiendrébeogo, M., Stanciu, C., & Trifan, A. V. (2018) · Neurophysiology · doi:10.1007/s11062-018-9748-9 · Cited by 9
Luca, B. D., Canozzi, A., Mosconi, C., Gastaldon, C., Papola, D., Metelli, A., Tedeschi, F., Amaddeo, F., Purgato, M., Solmi, M., et al. (2025) · The British Journal of Psychiatry · doi:10.1192/bjp.2025.18 · Cited by 12
Metadata
- Authors
- Borson, S., McDonald, G. J., Gayle, T., Deffebach, M., Lakshminarayan, S., & VanTuinen, C.
- Affiliations
- University of Washington (US)
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 33
- Issue
- 2
- Pages
- 190-201
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2040089352
- Cited by
- 277
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- nortriptyline, depression, chronic obstructive pulmonary disease, antidepressant treatment, comorbid depression, mood improvement, somatic symptoms, functional capacity, anxiety, pulmonary insufficiency, placebo effect, severely disabled patients
- MeSH terms
- Activities of Daily Living, Affect, Attitude to Health, Chronic Disease, Depressive Disorder, Dyspnea, Female, Humans, Lung Diseases, Obstructive, Male, Middle Aged, Nortriptyline, Patient Compliance, Placebos, Prednisone, Psychiatric Status Rating Scales
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
