A randomised single blind trial of a combined mumps measles rubella vaccine to evaluate serological response and reactions in the UK population
Abstract
Four hundred and twenty children were randomly assigned to receive either mumps measles rubella (MMR) vaccine (207) or measles vaccine (213) in a single blind study, to investigate the reactogenicity and serology of the MMR vaccine. There was no significant difference between the number of children developing symptoms after MMR vaccination to those developing symptoms after measles vaccination. Both vaccines are associated with a rash, temperature and restlessness five to thirteen days after vaccination. The serological response to measles vaccine was similar in both groups with 92-6% seroconverting with MMR, and 96-8% with measles. Seroconvertion against mumps and rubella with the MMR vaccine was 88% and 96% respectively. This study confirms the safety and efficacy of the MMR vaccine in a UK population.
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Edees 1991 concluded there was no significant difference between the numbers of children developing symptoms after MMR or measles vaccination.
“The trial by Edees concluded that there was no significant difference between the numbers of children developing symptoms after MMR or measles vaccination (Edees 1991).”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Edees 1991
Cites
FREQUENCY OF TRUE ADVERSE REACTIONS TO MEASLES-MUMPS-RUBELLA VACCINE
Peltola, H., & Heinonen, O. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91044-5 · Cited by 212 · see citing works
Immunisation against infectious disease.
Festenstein, F., Empey, D. W., Wheeler, W. F., Rudd, R., & McCarthy, O. R. (1988) · BMJ · doi:10.1136/bmj.297.6653.916 · Cited by 170 · see citing works
RAPID EFFECT ON ENDEMIC MEASLES, MUMPS, AND RUBELLA OF NATIONWIDE VACCINATION PROGRAMME IN FINLAND
Peltola, H., Kurki, T., Virtanen, M., et al. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92270-1 · Cited by 95 · see citing works
Antibody Response Following Measles-Mumps-Rubella Vaccine Under Conditions of Customary Use
Brunell, P. A. (1983) · JAMA · doi:10.1001/jama.1983.03340110023025 · Cited by 76 · see citing works
CHRISTENSON, B., Böttiger, M., & Heller, L. (1983) · BMJ · doi:10.1136/bmj.287.6389.389 · Cited by 60 · see citing works
Clinical Trial of a New Trivalent Measles-Mumps-Rubella Vaccine in Young Children
Vesikari, T. (1984) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1984.02140470043013 · Cited by 40 · see citing works
Serological evaluation of a measles, mumps, and rubella vaccine
Robertson, C. M., Bennett, V. J., Jefferson, N., & Mayon-White, R. T. (1988) · Archives of Disease in Childhood · doi:10.1136/adc.63.6.612 · Cited by 34 · see citing works
Sensitive neutralization test for virus antibody
Sato, H., Albrecht, P. G., Hicks, J. T., et al. (1978) · Archives of Virology · doi:10.1007/bf01317822 · Cited by 27 · see citing works
Popow‐Kraupp, T., Kundi, M., Ambrosch, F., et al. (1986) · Journal of Medical Virology · doi:10.1002/jmv.1890180109 · Cited by 25 · see citing works
An evaluation of measles, mumps and rubella vaccine in a population of Yorkshire infants
Dunlop, J. M., RaiChoudhury, K., Roberts, J. S. C., et al. (1989) · Public Health · doi:10.1016/s0033-3506(89)80002-2 · Cited by 23 · see citing works
Vesikari, T., ANDRÉ, F. E., Simoen, E., Florent, G., El, A.-L., HEIKKINEN, A., KUUSINEN, H., & TERHO, A. (1983) · Acta Paediatrica · doi:10.1111/j.1651-2227.1983.tb09661.x · Cited by 22 · see citing works
CHRISTENSON, B., & Böttiger, M. (1985) · Journal of Biological Standardization · doi:10.1016/s0092-1157(85)80023-8 · Cited by 19 · see citing works
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Vaccines for measles, mumps and rubella in children
Demicheli, V., Rivetti, A., Debalini, M. G., & Di Pietrantonj, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004407.pub3 · Cited by 372 · see citing works
- Authors
- Edees, S., Pullan, C. R., & Hull, D.
- Affiliations
- Queen's Medical Centre (GB)
- Corresponding author
- Edees, S.
- Venue
- Public Health
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 105
- Issue
- 2
- Pages
- 91-97
- ISSN
- 0033-3506 (ISSN-L)
- OpenAlex
- W2039201985
- Cited by
- 30
- References
- 12
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2013: 5 · 2012: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Public Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- measles vaccine, MMR vaccine, vaccine reactogenicity, seroconversion, vaccine safety, vaccine efficacy, children, mumps, rubella, measles
- MeSH terms
- Drug Combinations, United Kingdom, Humans, Infant, Measles Vaccine, Mumps Vaccine, Random Allocation, Rubella Vaccine, Measles-Mumps-Rubella Vaccine
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