Haemozoin as a marker of placental parasitization
Abstract
Both Plasmodium vivax and P. falciparum malaria can cause the delivery of low birthweight babies. In this report, we have quantitated haemozoin levels in placentas from women living on the Thai-Burmese border in a region of low transmission for both P. falciparum and P. vivax malaria from June 1995 to January 2000. P. falciparum malaria infections during pregnancy lead to the accumulation of haemozoin (malaria pigment) in the placenta, especially in infections near term and in primigravid pregnancies. Haemozoin concentration was not associated with adverse birth outcomes. Women with P. vivax infections during pregnancy do not have measurable levels of placental haemozoin suggesting that P. vivax-infected erythrocytes do not accumulate in the placenta as much as P. falciparum-infected ones.
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Hemozoin can persist for months following treatment of a documented infection, and the extent of hemozoin deposition is thought to correlate with cumulative exposure, with levels associated with gravidity, degree of parasitemia at treatment and reinfection before delivery.
“Hemozoin can persist for months in women following treatment of a documented infection [58], and the extent of hemozoin deposition is thought to correlate with cumulative exposure [54] such that levels have been associated with gravidity, the degree of parasitemia at the time of treatment and reinfection before delivery [57].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [58]
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Saito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408371
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408395
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408407
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408404
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408386
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408374
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408401
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408398
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408389
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408377
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408392
Self-citationSaito, M., Mansoor, R., Kennon, K., Anvikar, A. R., Ashley, E. A., Chandramohan, D., Cohee, L. M., D’Alessandro, U., Genton, B., Gilder, M. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12408380
Self-citation
- Authors
- McGready, R., Brockman, A., Cho, T., Levesque, M. A., Tkachuk, A. N., Meshnick, S. R., & Nosten, F.
- Affiliations
- Mahidol University (TH)
- Shoklo Malaria Research Unit (TH)
- University of Michigan (US)
- Corresponding author
- McGready, Rose
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11
- Volume
- 96
- Issue
- 6
- Pages
- 644-646
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1988250570
- Cited by
- 35
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 13 · 2019: 1 · 2017: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Royal Society
- University of Oxford
- Mahidol University
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- hemozoin, placental malaria, Plasmodium falciparum, Plasmodium vivax, malaria in pregnancy, placenta, low birth weight, primigravida, adverse birth outcomes, Thai-Myanmar border
- MeSH terms
- Analysis of Variance, Female, Hemeproteins, Humans, Infant, Low Birth Weight, Infant, Newborn, Placenta, Placenta Diseases, Pregnancy, Regression Analysis, Biomarkers, Pregnancy Complications, Parasitic, Malaria, Falciparum, Malaria, Vivax, Parasitemia
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