Placental Malaria in Colombia: Histopathologic Findings in Plasmodium vivax and P. falciparum Infections
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Studies on gestational malaria and placental malaria have been scarce in malaria-endemic areas of the Western Hemisphere. To describe the histopathology of placental malaria in Colombia, a longitudinal descriptive study was conducted. In this study, 179 placentas were studied by histologic analysis (112 with gestational malaria and 67 negative for malaria). Placental malaria was confirmed in 22.35%, 50.0% had previous infections, and 47.5% had acute infections. Typical malaria-associated changes were observed in 37%. The most common changes were villitis, intervillitis, deciduitis, increased fibrin deposition, increased syncytial knots, mononuclear (monocytes/macrophages and lymphocytes), polymorphonuclear cell infiltration, and trophozoites in fetal erythrocytes. No association was found between type of placental changes observed and histopathologic classification of placental malaria. The findings are consistent with those reported for placental malaria in other regions. Plasmodium vivax was the main parasite responsible for placental and gestational malaria, but its role in the pathogenesis of placental malaria was not conclusive.
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Malaria parasites can affect the placenta directly by causing a mechanical compromise of the blood circulation.
“Malaria parasites can affect the placenta directly by causing a mechanical compromise of the blood circulation”
From The Impact Of Malaria Parasites On The Placenta And Perinatal Outcome At Korle Bu Teaching Hospital, Accra, Ghana: A Case Control Study (2022) · cites this paper as [12]
Malaria parasites can affect the placenta indirectly by interfering with placental function and/or inducing pathological lesions.
“indirectly by interfering with the function and/or inducing pathological lesions”
From The Impact Of Malaria Parasites On The Placenta And Perinatal Outcome At Korle Bu Teaching Hospital, Accra, Ghana: A Case Control Study (2022) · cites this paper as [12]
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- Authors
- Carmona-Fonseca, J., Arango, E., & Maestre, A.
- Affiliations
- Universidad de Antioquia (CO)
- ORCID
- Arango, Eliana
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2013-06-05
- Volume
- 88
- Issue
- 6
- Pages
- 1093-1101
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC3752808
- OpenAlex
- W2160974765
- Cited by
- 42
- References
- 11
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 7 · 2014: 6 · 2013: 3
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- placental malaria, malaria in pregnancy, Plasmodium vivax, Plasmodium falciparum, placental pathology, villitis, deciduitis, syncytial knots, fibrin deposition, malaria pathogenesis, Colombia
- MeSH terms
- Adolescent, Adult, Colombia, Female, Humans, Placenta, Placenta Diseases, Plasmodium falciparum, Plasmodium vivax, Pregnancy, Case-Control Studies, Malaria, Falciparum, Malaria, Vivax, Endemic Diseases, Young Adult
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