Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis
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Key Points: ts-AML (arising from treated antecedent hematological disorder) is less responsive to currently applied treatment strategies. Future trial designs should accommodate this entity as a distinct category, and patients would be best evaluated on investigational therapies.
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Both forms of secondary leukaemia have an extremely poor prognosis despite the most intensive therapies such as bone marrow transplantation.
“Both forms of secondary leukaemia have an extremely poor prognosis despite the most intensive therapies such as bone marrow transplantation 155,159 .”
From Osteosarcoma (2022) · cites this paper as [159]
In trials for relapsed/refractory osteosarcoma, MTKIs were effective in reducing PFS and became mainstay.
“In these trials, MTKIs were effective in reducing PFS, becoming the mainstay of treatments for patients with relapsed disease.”
From Osteosarcoma (2022) · cites this paper as [159]
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The Cup Runneth Over: Treatment Strategies for Newly Diagnosed Acute Myeloid Leukemia
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Self-citationConsenso de leucemia mieloide aguda en México
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- Authors
- Boddu, P., Kantarjian, H. M., Garcia-Manero, G., Ravandi, F., Verstovsek, S., Jabbour, E., Borthakur, G., Konopleva, M., Bhalla, K. N., Daver, N., DiNardo, C. D., Benton, C. B., Takahashi, K., Estrov, Z., Pierce, S. R., Andreeff, M., Cortes, J. E., & Kadia, T. M.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
- ORCID
- Venue
- Blood Advances
- Publisher
- American Society of Hematology
- Published
- 2017-07-19
- Volume
- 1
- Issue
- 17
- Pages
- 1312-1323
- ISSN
- 2473-9529 (ISSN-L)
- 2473-9537
- PMC
- PMC5727976
- OpenAlex
- W2738685991
- Cited by
- 112
- References
- 55
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 25 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 5
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Blood Advances (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Cancer Institute (P01CA049639, R01CA171338, R01CA173877, P30CA016672)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Keywords
- secondary acute myeloid leukemia, treatment-related acute myeloid leukemia, poor prognosis, adverse karyotype, overall survival, risk stratification, younger patients
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