Cited by 112Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesChronic Myeloid Leukemia Treatments

Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis

Open access
Boddu, Prajwal, Kantarjian, Hagop M., Garcia-Manero, Guillermo, Ravandi, Farhad, Verstovsek, Srdan, Jabbour, Elias, Borthakur, Gautam, Konopleva, Marina +10 more·2017·Blood Advances

Abstract

Key Points: ts-AML (arising from treated antecedent hematological disorder) is less responsive to currently applied treatment strategies. Future trial designs should accommodate this entity as a distinct category, and patients would be best evaluated on investigational therapies.

Integrity signals

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Crossref · 10.1182/bloodadvances.2017008227

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56 of 56 references verified0 citation errors · 0 not checkable

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  • Both forms of secondary leukaemia have an extremely poor prognosis despite the most intensive therapies such as bone marrow transplantation.

    “Both forms of secondary leukaemia have an extremely poor prognosis despite the most intensive therapies such as bone marrow transplantation 155,159 .”

    From Osteosarcoma (2022) · cites this paper as [159]

  • In trials for relapsed/refractory osteosarcoma, MTKIs were effective in reducing PFS and became mainstay.

    “In these trials, MTKIs were effective in reducing PFS, becoming the mainstay of treatments for patients with relapsed disease.”

    From Osteosarcoma (2022) · cites this paper as [159]

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Authors
Boddu, P., Kantarjian, H. M., Garcia-Manero, G., Ravandi, F., Verstovsek, S., Jabbour, E., Borthakur, G., Konopleva, M., Bhalla, K. N., Daver, N., DiNardo, C. D., Benton, C. B., Takahashi, K., Estrov, Z., Pierce, S. R., Andreeff, M., Cortes, J. E., & Kadia, T. M.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
Venue
Blood Advances
Published
2017-07-19
Volume
1
Issue
17
Pages
1312-1323
ISSN
  • 2473-9529 (ISSN-L)
  • 2473-9537
OpenAlex
W2738685991
Cited by
112
References
55
Citations by year
2026: 2 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 25 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 5
FWCI
7.59
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Blood Advances (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Cancer Institute (P01CA049639, R01CA171338, R01CA173877, P30CA016672)
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
Keywords
secondary acute myeloid leukemia, treatment-related acute myeloid leukemia, poor prognosis, adverse karyotype, overall survival, risk stratification, younger patients

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