The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Ageing of the brain
Abstract
The brains of individuals who are cognitively normal show age-related changes that include an overall reduction in the brain volume and weight and enlargement of the brain ventricles. These changes are partly the result of nerve cell loss but accurate estimates of neuronal loss are notoriously difficult to make. There is loss of synapses and dendritic pruning in the aged brain but in selected areas rather than globally. Neurofibrillary tangles and senile plaques are the neuropathological hallmark of Alzheimer's disease in which they are more abundant and widespread than in the brains of intellectually intact elderly people. Alzheimer's disease has, therefore, been regarded as accelerated brain ageing, however, since there is a strong genetic contribution to developing the disease it implies that it may not be the inevitable, even if frequent, consequence of old age. The interplay between genetic and environmental factors probably determines the degree of pathological brain ageing and whether or not individuals develop dementia.
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“Decades of clinical-pathological correlative studies, now corroborated by a decade of neuroimaging studies, also demonstrate a sizable percentage of the non-demented elderly have plaques [40, 51, 54, 55, 58–68].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [40]
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Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943
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A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
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Series Introduction: Neurodegeneration: What is it and where are we?
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Disconnected aging: Cerebral white matter integrity and age-related differences in cognition
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Metadata
- Authors
- Anderton, B. H.
- Affiliations
- King's College London (GB)
- Corresponding author
- Anderton, Brian H
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 123
- Issue
- 7
- Pages
- 811-817
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2028366530
- Cited by
- 187
- References
- 50
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 14 · 2019: 9 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 17 · 2012: 10
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Keywords
- brain aging, brain atrophy, ventriculomegaly, neuronal loss, synaptic loss, dendritic pruning, neurofibrillary tangles, amyloid plaques, Alzheimer's disease, dementia, genetic risk factors, environmental factors
- MeSH terms
- Aging, Alzheimer Disease, Brain, Humans
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