Cited by 187Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAging and Gerontology Research

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Ageing of the brain

Anderton, Brian H·2002·Mechanisms of Ageing and Development

DOI 10.1016/s0047-6374(01)00426-2

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Abstract

The brains of individuals who are cognitively normal show age-related changes that include an overall reduction in the brain volume and weight and enlargement of the brain ventricles. These changes are partly the result of nerve cell loss but accurate estimates of neuronal loss are notoriously difficult to make. There is loss of synapses and dendritic pruning in the aged brain but in selected areas rather than globally. Neurofibrillary tangles and senile plaques are the neuropathological hallmark of Alzheimer's disease in which they are more abundant and widespread than in the brains of intellectually intact elderly people. Alzheimer's disease has, therefore, been regarded as accelerated brain ageing, however, since there is a strong genetic contribution to developing the disease it implies that it may not be the inevitable, even if frequent, consequence of old age. The interplay between genetic and environmental factors probably determines the degree of pathological brain ageing and whether or not individuals develop dementia.

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Authors: Anderton, B. H.
Affiliations: King's College London (GB)
Corresponding author: Anderton, Brian H
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 2002-04
Volume: 123
Issue: 7
Pages: 811-817
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/s0047-6374(01)00426-2
OpenAlex: W2028366530
Cited by: 187
References: 50
Citations by year: 2026: 9 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 14 · 2019: 9 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 17 · 2012: 10
FWCI: 1.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Wellcome Trust
Medical Research Council
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords: brain aging, brain atrophy, ventriculomegaly, neuronal loss, synaptic loss, dendritic pruning, neurofibrillary tangles, amyloid plaques, Alzheimer's disease, dementia, genetic risk factors, environmental factors
MeSH terms: Aging, Alzheimer Disease, Brain, Humans

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