Conserved features of endocytosis in Dictyostelium
Abstract
Endocytosis in protozoa is often regarded as largely different from the pathways operating in mammalian cells. Experiments in the amoeba Dictyostelium, one of the genetically tractable single-celled organisms, have allowed us to manipulate the flow through endocytic compartments and to study the dynamic distribution of molecules by means of green fluorescent protein fusions. This review attempts to compile the molecular data available from Dictyostelium and assign them to specific steps of internalization by phagocytosis or macropinocytosis and to subsequent stages of the endocytic pathway. Parallels to phagocytes of the mammalian immune system are emphasized. The major distinctive feature between mammalian phagocytes and free-living cells is the need for osmoregulation. Therefore Dictyostelium cells possess a contractile vacuole that has occasionally obscured analysis of endocytosis but is now found to be entirely separate from endocytic organelles. In conclusion, the potential of Dictyostelium amoebas to provide a model system of mammalian phagocytes is ever increasing.
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Molecular mechanisms of phagocytosis are conserved throughout evolution.
“Molecular mechanisms of phagocytosis are conserved throughout evolution.”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [7]
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Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis
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Proteomics Fingerprinting of Phagosome Maturation and Evidence for the Role of a Gα during Uptake
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Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium
Sillo, A., Bloomfield, G., Balest, A., Balbo, A., Pergolizzi, B., Peracino, B., Skelton, J., Ivens, A., & Bozzaro, S. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-291 · Cited by 69 · see citing works
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- Authors
- Maniak, M.
- Affiliations
- University of Kassel (DE)
- Corresponding author
- Maniak, Markus
- ORCID
- Maniak, Markus
- Venue
- International Review of Cytology
- Publisher
- Elsevier
- Published
- 2002
- Volume
- 221
- Pages
- 257-287
- ISSN
- 0074-7696 (ISSN-L)
- OpenAlex
- W1525601857
- Cited by
- 52
- References
- 6
- Citations by year
- 2024: 1 · 2022: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 6.00
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of cytology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
- Physical Sciences › Engineering › Biomedical Engineering › Slime Mold and Myxomycetes Research
- Keywords
- endocytosis, Dictyostelium, phagocytosis, macropinocytosis, endocytic pathway, contractile vacuole, osmoregulation, phagocytes, amoebae, GFP fusion protein
- MeSH terms
- Animals, Cytoskeleton, Dictyostelium, Endocytosis, Biological Evolution, Lysosomes, Phagocytosis, Vacuoles, Water-Electrolyte Balance, Signal Transduction
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