The DOI matches its Crossref record; 360 of the 360 references it cites were found in a registry or an index.
Sialic Acids in Molecular and Cellular Interactions
Open accessAbstract
Sialic acids (Sias) are terminal components of many glycoproteins and glycolipids especially of higher animals. In this exposed position they contribute significantly to the structural properties of these molecules, both in solution and on cell surfaces. Therefore, it is not surprising that Sias are important regulators of cellular and molecular interactions, in which they play a dual role. They can either mask recognition sites or serve as recognition determinants. Whereas the role of Sias in masking and in binding of pathogens to host cells has been documented over many years, their role in nonpathological cellular interaction has only been shown recently. The aim of this chapter is to summarize our knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules. Finally, perspectives for future research on these topics are discussed.
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Cites
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Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
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BackgroundDecoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154
PSA-NCAM in mammalian structural plasticity and neurogenesis
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Metadata
- Authors
- Kelm, S., & Schauer, R.
- Venue
- International Review of Cytology
- Publisher
- Elsevier
- Published
- 1997
- Volume
- 175
- Pages
- 137-240
- ISSN
- 0074-7696 (ISSN-L)
- OpenAlex
- W1565376547
- Cited by
- 458
- References
- 360
- FWCI
- 26.93
- Type
- book chapter
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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