Targeting coenzyme Q derivatives to mitochondria
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The TPP+ moiety can have pharmacological or inhibitory properties due to its interactions with mitochondria, which can potentially be modified by both the linker group and the functional pharmacophores possessing antioxidant properties.
“The TPP+ moiety can also in principle have pharmacological or inhibitory properties due to its interactions with mitochondria which can potentially be modified by both the linker group and the functional pharmacophores possessing antioxidant properties [19].”
From Mitochondrially targeted compounds and their impact on cellular bioenergetics (2013) · cites this paper as [19]
Cites
Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091 · see citing works
Self-citationSelective targeting of bioactive compounds to mitochondria
Murphy, M. P. (1997) · Trends in Biotechnology · doi:10.1016/s0167-7799(97)01068-8 · Cited by 366 · see citing works
Self-citationSaretzki, G., Murphy, M. P., & Von Zglinicki, T. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00040.x · Cited by 203 · see citing works
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Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173 · see citing works
Self-citationMitochondria-Targeted Small Molecule Therapeutics and Probes
Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399 · see citing works
Self-citationAntioxidant and prooxidant properties of mitochondrial Coenzyme Q
James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.025 · Cited by 292 · see citing works
Self-citationMitochondrially targeted compounds and their impact on cellular bioenergetics
Reily, C., Mitchell, T., Chacko, B. K., Benavides, G. A., Murphy, M. P., & Darley-Usmar, V. M. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.009 · Cited by 227 · see citing works
Self-citationPorteous, C. M., Logan, A., Evans, C., Ledgerwood, E. C., Menon, D. K., Aigbirhio, F., Smith, R. A. J., & Murphy, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.06.001 · Cited by 121 · see citing works
Self-citation
- Authors
- Smith, R. A. J., Kelso, G. F., James, A. M., & Murphy, M. P.
- Affiliations
- University of Otago (NZ)
- Venue
- Methods in Enzymology
- Publisher
- Elsevier
- Published
- 2004
- Volume
- 382
- Pages
- 45-67
- ISSN
- 0076-6879 (ISSN-L)
- OpenAlex
- W1507385544
- Cited by
- 87
- References
- 3
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 10
- FWCI
- 5.73
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society
- Medical Research Council
- Health Research Council of New Zealand
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- coenzyme Q10, MitoQ, mitochondrial targeting, antioxidants, hydrophobicity, bioavailability, stable isotope labeling, radioactive isotope labeling, mitochondrial uptake, inner mitochondrial membrane
- MeSH terms
- Animals, Intracellular Membranes, Mitochondria, Oxidation-Reduction, Thermodynamics, Ubiquinone
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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