Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

Measurement of protein using bicinchoninic acid

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Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

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Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

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Mitochondrial Membrane Potential in Living Cells

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Selective fluorescent imaging of superoxide <i>in vivo</i> using ethidium-based probes

Robinson, K. M., Janes, M. S., Pehar, M., Monette, J. S., Ross, M. F., Hagen, T. M., Murphy, M. P., & Beckman, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601945103 · Cited by 777 · see citing works

Delivery of bioactive molecules to mitochondria <i>in</i> <i>vivo</i>

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A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living Cells

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Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

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A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease

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Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

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Selective targeting of an antioxidant to mitochondria

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Drug delivery to mitochondria: the key to mitochondrial medicine

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Subcellular components: preparation and fractionation;

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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage

Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02250.x · Cited by 379 · see citing works

Mitochondria-Targeted Antioxidant MitoQ ₁₀ Improves Endothelial Function and Attenuates Cardiac Hypertrophy

Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A. J., Cochemé, H. M., Murphy, M. P., & Dominiczak, A. F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130351 · Cited by 367 · see citing works

Selective targeting of bioactive compounds to mitochondria

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Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species

James, A. M., Cochemé, H. M., Smith, R. A. J., & Murphy, M. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501527200 · Cited by 353 · see citing works

Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

Murphy, M. P., Echtay, K. S., Blaikie, F. H., Asin-Cayuela, J., Cochemé, H. M., Green, K., Buckingham, J. A., Taylor, E. R., Hurrell, F., Hughes, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308529200 · Cited by 304 · see citing works

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

Lowes, D. A., Thottakam, B. M. V., Webster, N. R., Murphy, M. P., & Galley, H. F. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.003 · Cited by 261 · see citing works

A mitochondria-targeted <i>S</i> -nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

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Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

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Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

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Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: Role of mitochondrial superoxide

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Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant

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Specific Modification of Mitochondrial Protein Thiols in Response to Oxidative Stress

Lin, T., Hughes, G., Muratovska, A., Blaikie, F. H., Brookes, P. S., Darley-Usmar, V. M., Smith, R. A. J., & Murphy, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110797200 · Cited by 180 · see citing works

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

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Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents

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PREPARATION OF MITOCHONDRIA FROM ANIMAL TISSUES AND YEASTS

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The mitochondrial uncoupler 2,4‐dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia

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Accumulation of lipophilic dications by mitochondria and cells

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Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium.

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Synthesis and Characterization of Thiobutyltriphenylphosphonium Bromide, a Novel Thiol Reagent Targeted to the Mitochondrial Matrix

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Complex I Dysfunction and Tolerance to Nitroglycerin

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Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury

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Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers

Ross, M. F., Filipovska, A., Smith, R. A. J., Gait, M. J., & Murphy, M. P. (2004) · Biochemical Journal · doi:10.1042/bj20041095 · Cited by 90 · see citing works

Targeting coenzyme Q derivatives to mitochondria

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Hydrated Tetrabutylammonium Fluoride as a Powerful Nucleophilic Fluorinating Agent

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Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV‐irradiation: Protective effects of SkQ1, lithium ions and insulin

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Detection, Characterization, and Decay Kinetics of ROS and Thiyl Adducts of Mito-DEPMPO Spin Trap

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Toxic Fluorine Compounds. III.1 ι-Fluoroalcohols

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Novel Phosphonium Salts Displayin Vitroandin VivoCytotoxic Activity against Human Ovarian Cancer Cell Lines

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Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide

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Chemoselective fluorination for primary alcohols

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Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS?

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Enhanced uptake of [11C]TPMP in canine brain tumor: a PET study.

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The Uncoupling Agent 2,4-Dinitrophenol Improves Mitochondrial Homeostasis following Striatal Quinolinic Acid Injections

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Specific targeting of a DNA‐alkylating reagent to mitochondria

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Quantitation and metabolism of mitoquinone, a mitochondria‐targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry

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Antineoplastic activity, synergism, and antagonism of triarylalkylphosphonium salts and their combinations.

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Effects of phosphonium compounds on Schistosoma mansoni

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Regioselective Synthesis of (+) -S-2-Amino-5-iodoacetamidopentanoic and (+) -S-2-amino-6-iodoacetamidohexanoic Acids

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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

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Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

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Mitochondrial pharmacology

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Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

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Mitochondria-Targeted Small Molecule Therapeutics and Probes

Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399 · see citing works

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.003 · Cited by 313 · see citing works

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

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A Targetable Fluorescent Sensor Reveals That Copper-Deficient SCO1 and SCO2 Patient Cells Prioritize Mitochondrial Copper Homeostasis

Dodani, S. C., Leary, S. C., Cobine, P. A., Winge, D. R., & Chang, C. J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2004158 · Cited by 300 · see citing works

NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

Vendrov, A. E., Vendrov, K. C., Smith, A., Yuan, J., Sumida, A., Robidoux, J., Runge, M. S., & Madamanchi, N. R. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6221 · Cited by 219 · see citing works

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

Dare, A. J., Bolton, E. A., Pettigrew, G. J., Bradley, J. A., Saeb-Parsy, K., & Murphy, M. P. (2015) · Redox Biology · doi:10.1016/j.redox.2015.04.008 · Cited by 202 · see citing works

Micelles Loaded With Puerarin And Modified With Triphenylphosphonium Cation Possess Mitochondrial Targeting And Demonstrate Enhanced Protective Effect Against Isoprenaline-Induced H9c2 Cells Apoptosis

Li, W., Wu, J., Xiang, D., Luo, S., Hu, X.-B., Tang, T., Sun, T., & Liu, X.-Y. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s219670 · Cited by 187 · see citing works

Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

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Understanding and preventing mitochondrial oxidative damage

Murphy, M. P. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160108 · Cited by 160 · see citing works

The Mitochondrial Complex(I)ty of Cancer

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Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery

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Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing

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Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

Cochemé, H. M., Logan, A., Prime, T. A., Abakumova, I., Quin, C., McQuaker, S. J., Patel, J. V., Fearnley, I. M., James, A. M., Porteous, C. M., et al. (2012) · Nature Protocols · doi:10.1038/nprot.2012.035 · Cited by 128 · see citing works

Power of mitochondrial drug delivery systems to produce innovative nanomedicines

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Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic TargetsReviewing Editors: Markus Bachschmid, Dylan Burger, Vittorio Calabrese, Amadou Camara, Lukas Kubala, Giuseppe Poli, and Chandan K. Sen

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The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

Dare, A. J., Logan, A., Prime, T. A., Rogatti, S., Goddard, M., Bolton, E. M., Bradley, J. A., Pettigrew, G. J., Murphy, M. P., & Saeb-Parsy, K. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.05.007 · Cited by 119 · see citing works

Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease

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Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

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Mitochondrial-Targeted Curcuminoids: A Strategy to Enhance Bioavailability and Anticancer Efficacy of Curcumin

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A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

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Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model

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Moving Forwards by Blocking Back-Flow

Pell, V. R., Chouchani, E. T., Murphy, M. P., Brookes, P. S., & Krieg, T. (2016) · Circulation Research · doi:10.1161/circresaha.115.306569 · Cited by 101 · see citing works

MitoNeoD: A Mitochondria-Targeted Superoxide Probe

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