Cited by 105Glutathione Transferases and PolymorphismsPharmacogenetics and Drug MetabolismRedox biology and oxidative stress

Phylogenies of glutathione transferase families

Pearson, William R.·2005·Methods in Enzymology

Abstract

The best known glutathione transferase family, with its class-alpha, -mu, -pi, -omega, -sigma, -theta, and -zeta subdivisions, is only one of four, or perhaps five, ancient protein families that conjugate glutathione or use a glutathione intermediate: (1) the cytoplasmic family, (2) the mitochondrial (kappa) family, (3) the microsomal (MAPEG) family, which may actually be two separate families, and (4) the fosphomycin/glyoxalase family. Although the cytoplasmic family is perhaps the most diverse, all four of these families have homologs in both prokaryotes and eukaryotes; it is striking that at least three, and perhaps as many as five, different protein folds capable of binding and positioning glutathione for a nucleophilic attack emerged more than 2 billion years ago. This chapter presents phylogenies for the four (or five) glutathione transferase families, focusing on the statistical evidence for homology (and non-homology).

Integrity signals

Registry

Crossref · 10.1016/s0076-6879(05)01012-8

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Six sea urchin theta-class GST genes are most closely related to vertebrate theta-class GSTs rather than insect theta-class GSTs.

    “The six urchin theta-class GST genes are most closely related to vertebrate theta-class GSTs, rather than to the insect thetaclass GSTs, aiding the phylogenetic resolution of this widespread GST-family (Nebert and Vasiliou, 2004;Pearson, 2005).”

Cites

Flagged first, then by citations

1 of the 33 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Pearson, W. R.
Affiliations
University of Virginia (US)
Corresponding author
Pearson, William R.
Venue
Methods in Enzymology
Publisher
Elsevier
Published
2005
Volume
401
Pages
186-204
ISSN
0076-6879 (ISSN-L)
OpenAlex
W1538865925
Cited by
105
References
33
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 6 · 2012: 4
FWCI
10.12
Type
book chapter
Language
en
Open access
closed
Locations
  • Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
glutathione S-transferase, protein family phylogeny, glutathione conjugation, protein fold evolution, homology detection
MeSH terms
Animals, Cytoplasm, Multigene Family, Glutathione Transferase, Humans, Isoenzymes, Microsomes, Phylogeny, Thioredoxins, Evolution, Molecular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review