The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Phylogenies of Glutathione Transferase Families
Abstract
The best known glutathione transferase family, with its class-alpha, -mu, -pi, -omega, -sigma, -theta, and -zeta subdivisions, is only one of four, or perhaps five, ancient protein families that conjugate glutathione or use a glutathione intermediate: (1) the cytoplasmic family, (2) the mitochondrial (kappa) family, (3) the microsomal (MAPEG) family, which may actually be two separate families, and (4) the fosphomycin/glyoxalase family. Although the cytoplasmic family is perhaps the most diverse, all four of these families have homologs in both prokaryotes and eukaryotes; it is striking that at least three, and perhaps as many as five, different protein folds capable of binding and positioning glutathione for a nucleophilic attack emerged more than 2 billion years ago. This chapter presents phylogenies for the four (or five) glutathione transferase families, focusing on the statistical evidence for homology (and non-homology).
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“The six urchin theta-class GST genes are most closely related to vertebrate theta-class GSTs, rather than to the insect thetaclass GSTs, aiding the phylogenetic resolution of this widespread GST-family (Nebert and Vasiliou, 2004;Pearson, 2005).”
From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Pearson, 2005
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An In Silico Investigation of the Structural and Evolutionary Features of MAPEG Proteins in Bacteria
Federici, L., Masulli, M., Laurenzi, V. D., & Allocati, N. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48090939
Metadata
- Authors
- Pearson, W. R.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Pearson, William R.
- ORCID
- Pearson, William R.
- Venue
- Methods in Enzymology
- Publisher
- Elsevier
- Published
- 2005
- Volume
- 401
- Pages
- 186-204
- ISSN
- 0076-6879 (ISSN-L)
- OpenAlex
- W1538865925
- Cited by
- 105
- References
- 33
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 6 · 2012: 4
- FWCI
- 10.12
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- glutathione S-transferase, protein family phylogeny, glutathione conjugation, protein fold evolution, homology detection
- MeSH terms
- Animals, Cytoplasm, Multigene Family, Glutathione Transferase, Humans, Isoenzymes, Microsomes, Phylogeny, Thioredoxins, Evolution, Molecular
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