Cited by 105Glutathione Transferases and PolymorphismsPharmacogenetics and Drug MetabolismRedox biology and oxidative stress

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Phylogenies of Glutathione Transferase Families

Pearson, William R.·2005·Methods in Enzymology

DOI 10.1016/s0076-6879(05)01012-8

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Abstract

The best known glutathione transferase family, with its class-alpha, -mu, -pi, -omega, -sigma, -theta, and -zeta subdivisions, is only one of four, or perhaps five, ancient protein families that conjugate glutathione or use a glutathione intermediate: (1) the cytoplasmic family, (2) the mitochondrial (kappa) family, (3) the microsomal (MAPEG) family, which may actually be two separate families, and (4) the fosphomycin/glyoxalase family. Although the cytoplasmic family is perhaps the most diverse, all four of these families have homologs in both prokaryotes and eukaryotes; it is striking that at least three, and perhaps as many as five, different protein folds capable of binding and positioning glutathione for a nucleophilic attack emerged more than 2 billion years ago. This chapter presents phylogenies for the four (or five) glutathione transferase families, focusing on the statistical evidence for homology (and non-homology).

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Authors: Pearson, W. R.
Affiliations: University of Virginia (US)
Corresponding author: Pearson, William R.
ORCID: Pearson, William R.
Venue: Methods in Enzymology
Publisher: Elsevier
Published: 2005
Volume: 401
Pages: 186-204
ISSN: 0076-6879 (ISSN-L)
DOI: 10.1016/s0076-6879(05)01012-8
OpenAlex: W1538865925
Cited by: 105
References: 33
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 6 · 2012: 4
FWCI: 10.12
Type: book chapter
Language: en
Open access: closed
Locations: Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: glutathione S-transferase, protein family phylogeny, glutathione conjugation, protein fold evolution, homology detection
MeSH terms: Animals, Cytoplasm, Multigene Family, Glutathione Transferase, Humans, Isoenzymes, Microsomes, Phylogeny, Thioredoxins, Evolution, Molecular

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Phylogenies of Glutathione Transferase Families

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