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The Liposomal Formulation of Doxorubicin

Abraham, Sheela A., Waterhouse, Dawn N., Mayer, Lawrence D., Cullis, Pieter R., Madden, Thomas D., Bally, Marcel B.·2005·Methods in Enzymology
DOI 10.1016/s0076-6879(05)91004-5
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Abstract

Doxorubicin is the best known and most widely used member of the anthracycline antibiotic group of anticancer agents. It was first introduced in the 1970s, and since that time has become one of the most commonly used drugs for the treatment of both hematological and solid tumors. The therapy-limiting toxicity for this drug is cardiomyopathy, which may lead to congestive heart failure and death. Approximately 2% of patients who have received a cumulative (lifetime) doxorubicin dose of 450-500 mg?m(2) will experience this condition. An approach to ameliorating doxorubicin-related toxicity is to use drug carriers, which engender a change in the pharmacological distribution of the drug, resulting in reduced drug levels in the heart. Examples of these carrier systems include lipid-based (liposome) formulations that effect a beneficial change in doxorubicin biodistribution, with two formulations approved for clinical use. Drug approval was based, in part, on data suggesting that beneficial changes in doxorubicin occurred in the absence of decreased therapeutic activity. Preclinical (animal) and clinical (human) studies showing that liposomes can preferentially accumulate in tumors have provided a rationale for improved activity. Liposomes represent ideal drug delivery systems, as the microvasculature in tumors is typically discontinuous, having pore sizes (100-780 nm) large enough for liposomes to move from the blood compartment into the extravascular space surrounding the tumor ce…

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Metadata

Authors
Abraham, S. A., Waterhouse, D. N., Mayer, L. D., Cullis, P. R., Madden, T. D., & Bally, M. B.
Venue
Methods in Enzymology
Publisher
Elsevier
Published
2005
Pages
71-97
ISSN
0076-6879
DOI
10.1016/s0076-6879(05)91004-5
Cited by
355
References
0
Language
en

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CoChat. (2026). Citation check: The Liposomal Formulation of Doxorubicin. https://app.cochat.ai/papers/10.1016/s0076-6879(05)91004-5
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Abraham, S. A., Waterhouse, D. N., Mayer, L. D., Cullis, P. R., Madden, T. D., & Bally, M. B. (2005). The Liposomal Formulation of Doxorubicin. Methods in Enzymology. https://doi.org/10.1016/s0076-6879(05)91004-5