The DOI matches its Crossref record; 371 of the 374 references it cites were found in a registry or an index.
Glucocorticoids, chronic stress, and obesity
Abstract
Glucocorticoids either inhibit or sensitize stress-induced activity in the hypothalamo-pituitary-adrenal (HPA) axis, depending on time after their administration, the concentration of the steroids, and whether there is a concurrent stressor input. When there are high glucocorticoids together with a chronic stressor, the steroids act in brain in a feed-forward fashion to recruit a stress-response network that biases ongoing autonomic, neuroendocrine, and behavioral outflow as well as responses to novel stressors. We review evidence for the role of glucocorticoids in activating the central stress-response network, and for mediation of this network by corticotropin-releasing factor (CRF). We briefly review the effects of CRF and its receptor antagonists on motor outflows in rodents, and examine the effects of glucocorticoids and CRF on monoaminergic neurons in brain. Corticosteroids stimulate behaviors that are mediated by dopaminergic mesolimbic "reward" pathways, and increase palatable feeding in rats. Moreover, in the absence of corticosteroids, the typical deficits in adrenalectomized rats are normalized by providing sucrose solutions to drink, suggesting that there is, in addition to the feed-forward action of glucocorticoids on brain, also a feedback action that is based on metabolic well being. Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society.
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“further work reported that weekly supplementation with 40000 IU vitamin D for 6 months had no significant effect on depressive symptom scores, when compared with placebo (54).”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [54]
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Self-citation
Metadata
- Authors
- Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., & Bell, M. E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Dallman, Mary F.
- ORCID
- Bhatnagar, Seema
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2006
- Volume
- 153
- Pages
- 75-105
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1553637564
- Cited by
- 198
- References
- 374
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 11 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 12
- FWCI
- 33.08
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institute on Drug Abuse (DA-16944, R01DA016944)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- glucocorticoids, chronic stress, obesity, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, CRF receptor antagonists, stress response networks, monoaminergic neurons, dopaminergic reward pathways, sucrose intake, adrenalectomy, metabolic feedback
- MeSH terms
- Animals, Chronic Disease, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Obesity, Pituitary-Adrenal System, Stress, Physiological
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