Serotonin–dopamine interaction: an overview
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Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviours. Moreover, recent evidence suggests that the dysfunction of dopamine (DA) and serotonin (5-hydroxytriptamine, 5-HT) neurotransmission might underlie the pathophysiology of neuropsychiatric disorders, including depression, schizophrenia, attention deficit hyperactivity disorders, drug abuse, Gilles de la Tourette's syndrome and Parkinson's disease.
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Serotonergic and dopaminergic markers are jointly present in their developmental origins, guidepost areas, as well as within the subdomains of the PFC, which is important for their intricate interaction later in life to establish higher cognitive functions.
“Serotonergic and dopaminergic markers are jointly present in their developmental origins, guidepost areas, as well as within the subdomains of the PFC, which is important for their intricate interaction later in life to establish higher cognitive functions [209, 232–234].”
From Development of prefrontal cortex (2022) · cites this paper as [234]
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- Authors
- ESPOSITO, E., DIMATTEO, V, & DIGIOVANNI, G.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- Corresponding author
- ESPOSITO, E
- ORCID
- ESPOSITO, E
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 172
- Pages
- 3-6
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1528809860
- Cited by
- 88
- References
- 17
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 6.62
- Type
- book chapter
- Language
- en
- Open access
- green
- www.um.edu.mt
- Licence
- other-oa
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- OAR@UM (University of Malta) (submittedVersion, other-oa)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- serotonin, dopamine, neurotransmission, neuropsychiatric disorders, depression, schizophrenia, attention deficit hyperactivity disorder, drug abuse, Tourette syndrome, Parkinson's disease
- MeSH terms
- Behavior, Mental Disorders, Brain, Dopamine, Humans, Synaptic Transmission, Serotonin
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