Perturbed Developmental Serotonin Signaling Affects Prefrontal Catecholaminergic Innervation and Cortical Integrity
Open accessAbstract
Proper development of the medial prefrontal cortex (mPFC), crucial for correct cognitive functioning, requires projections from, among others, the serotonergic (5-HT) and catecholaminergic systems, but it is unclear how these systems influence each other during development. Here, we describe the parallel development of the 5-HT and catecholaminergic prefrontal projection systems in rat and demonstrate a close engagement of both systems in the proximity of Cajal-Retzius cells. We further show that in the absence of the 5-HT transporter (5-HTT), not only the developing 5-HT but also the catecholaminergic system, including their projections towards the mPFC, are affected. In addition, the layer identity of the mPFC neurons and reelin-positive interneuron number and integration are altered in the absence of the 5-HTT. Together, our data demonstrate a functional interplay between the developing mPFC 5-HT and catecholaminergic systems, and call for a holistic approach in studying neurotransmitter systems-specific developmental consequences for adult behavior, to eventually allow the design of better treatment strategies for neuropsychiatric disorders.
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Serotonin exerts a significant trophic and modulatory function in neurodevelopmental processes such as proliferation, migration, and differentiation in cortical areas, including the PFC.
“It has become widely accepted that serotonin exerts a significant trophic and modulatory function in neurodevelopmental processes such as proliferation, migration and differentiation in cortical areas, including the PFC [119, 123, 125–129].”
From Development of prefrontal cortex (2022) · cites this paper as [123]
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- [59]Jacobowitz DM, Abott LC(1998) Chemoarchitectonic atlas of the developing mouse brain. CRC Press, Boca Raton. https://scholar.google.com/scholar_lookup? author=DM+Jacobowitz&author=LC+Abott&title=Chemoarchitectonic+atlas+of+the+developing+mouse+brain&publication_year=1998
Cited by
Sorted by citations
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Self-citationGestational Factors throughout Fetal Neurodevelopment: The Serotonin Link
Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M., & Homberg, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165850 · Cited by 86 · see citing works
Self-citationvan de Wijer, L., Garcia, L. P., Hanswijk, S. I., Rando, J., Middelman, A., ter Heine, R., Mast, Q. D., Martens, G. J. M., van der Ven, A. J. A. M., Kolk, S. M., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0420-y · Cited by 13 · see citing works
Self-citationGarcia, L. P., Van de Wijer, L., Hanswijk, S. I., Rando, J., Witteveen, J. S., Middelman, A., ter Heine, R., de Mast, Q., Martens, G. J. M., van der Ven, A. J. A. M., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114050 · Cited by 6 · see citing works
Self-citation
- Authors
- Garcia, L. P., Witteveen, J. S., Middelman, A., van Hulten, J. A., Martens, G. J. M., Homberg, J. R., & Kolk, S. M.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Kolk, Sharon M.
- Venue
- Molecular Neurobiology
- Published
- 2018-06-09
- Volume
- 56
- Issue
- 2
- Pages
- 1405-1420
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC6400880
- OpenAlex
- W2806865194
- Cited by
- 28
- References
- 101
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Neurobiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (BEX11914/13-0)
- Era-Net NEURON (RESPOND)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin signaling, catecholaminergic system, medial prefrontal cortex, 5-HT transporter, Cajal-Retzius cells, cortical integration, neuropsychiatric disorders
- MeSH terms
- Reelin Protein, Animals, Male, Neurons, Raphe Nuclei, Serotonin, Signal Transduction, Rats, Wistar, Prefrontal Cortex, Neurotransmitter Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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