Cited by 151Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.

Serotonin–dopamine interaction: electrophysiological evidence

DIGIOVANNI, G, DIMATTEO, V, PIERUCCI, M, ESPOSITO, E·2008·Progress in Brain Research

DOI 10.1016/s0079-6123(08)00903-5

Open this paper in CoChat — free account

Abstract

In this review, the most relevant data regarding serotonin (5-hydroxytryptamine, 5-HT)/dopamine (DA) interaction in the brain, as studied by both in vivo and in vitro electrophysiological methods, are reported and discussed. The bulk of neuroanatomical data available clearly indicate that DA-containing neurons in the brain receive a prominent innervation from 5-HT originating in the raphe nuclei of the brainstem. Furthermore, this modulation seems to be reciprocal; DA neurons innervate the raphe nuclei and exert a tonic excitatory effect on them. Compelling electrophysiological data show that 5-HT can exert complex effects on the electrical activity of midbrain DA neurons mediated by the various receptor subtypes. The main control seems to be inhibitory, this effect being more marked in the ventral tegmental area (VTA) as compared to the substantia nigra pars compacta (SNc). In spite of a direct effect of 5-HT by its receptors located on DA cells, 5-HT can modulate their activity indirectly, modifying gamma-amino-n-butyric acid (GABA)-ergic and glutamatergic input to the VTA and SNc. Although 5-HT/DA interaction in the brain has been extensively studied, much work remains to be done to clarify this issue. The recent development of subtype-selective ligands for 5-HT receptors will not only allow a detailed understanding of this interaction but also lead to development of new treatment strategies, appropriate for those neuropsychiatric disorders in which an alteration of the 5-HT/DA balance is supposed.

Integrity signals

Registry

Crossref · 10.1016/s0079-6123(08)00903-5

Cites

153 of 153 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,211
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Azmitia, E. C., & Segal, M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790311 · Cited by 1,908
Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,898
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Evidence for the existence of monoamine neurons in the central nervous system
Fuxé, K. (1965) · Cell and Tissue Research · doi:10.1007/bf00337069 · Cited by 1,567
EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.
Fuxé, K. (1965) · PubMed · Cited by 1,544
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346
Efferent connections of the substantia nigra and ventral tegmental area in the rat
Beckstead, R. M., Domesick, V. B., & Nauta, W. J. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)91001-1 · Cited by 1,293

Show all 153 references

Sorted by citations

International society of sports nutrition position stand: caffeine and performance
Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-5 · Cited by 686
International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance
Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00383-4 · Cited by 665
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vermeire, S., Audenaert, K., Vandermeulen, E., Mees, R. D., van Bree, H., Dobbeleir, A. A., Peremans, K. Y., De, R., Declercq, A., Maes, S., et al. (2011) · Cited by 297
Stress-related Serotonergic Systems: Implications for Symptomatology of Anxiety and Affective Disorders
Hale, M. W., Shekhar, A., & Lowry, C. A. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9827-1 · Cited by 220
Dorsal raphe dual serotonin-glutamate neurons drive reward by establishing excitatory synapses on VTA mesoaccumbens dopamine neurons
Wang, H.-L., Zhang, S., Qi, J., Wang, H., Cachope, R., Mejias-Aponte, C. A., Gomez, J. A., Mateo-Semidey, G. E., Beaudoin, G. M. J., Paladini, C. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.014 · Cited by 176
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System
Peters, K. Z., Cheer, J. F., & Tonini, R. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.02.001 · Cited by 180
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications
Deurwaerdère, P. D., & Giovanni, G. D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.004 · Cited by 170
Dopamine–serotonin interactions in attention-deficit hyperactivity disorder (ADHD)
Oades, R. D. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00926-6 · Cited by 167
Multiple Modes of Impulsivity in Parkinson's Disease
Nombela, C., Rittman, T., Robbins, T. W., & Rowe, J. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085747 · Cited by 142
Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum
Tanaka, T., Takano, Y., Tanaka, S., Hironaka, N., Kobayashi, K., Hanakawa, T., Watanabe, K., & Honda, M. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00006 · Cited by 125
“The extracellular serotonin level in the striatum was also measured, as it is known to be associated with the dopamine level (Di Giovanni et al., 2008; Navailles and De Deurwaerdere, 2011).”
Background
The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function
Parker, M. O., Brock, A. J., Walton, R. T., & Brennan, C. H. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00063 · Cited by 133
Early Life Stress, Depression And Parkinson’s Disease: A New Approach
Dallé, E., & Mabandla, M. V. (2018) · Molecular Brain · doi:10.1186/s13041-018-0356-9 · Cited by 131
Evidence for a Re-Evaluation of the Neurochemical and Anatomical Bases of Chemotherapy-Induced Vomiting
Darmani, N. A., & Ray, A. P. (2009) · Chemical Reviews · doi:10.1021/cr900117p · Cited by 110
The role of the serotonergic system at the interface of aggression and suicide
Bortolato, M., Pivac, N., Šeler, D. M., Perković, M. N., Pessia, M., & Giovanni, G. D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.015 · Cited by 118
In Vivo Effects of Amphetamine Analogs Reveal Evidence for Serotonergic Inhibition of Mesolimbic Dopamine Transmission in the Rat
Baumann, M. H., Clark, R. D., Woolverton, W. L., Wee, S., Blough, B. E., & Rothman, R. B. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.176271 · Cited by 110
Presynaptic control of serotonin on striatal dopamine function
Navailles, S., & Deurwaerdère, P. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2029-y · Cited by 109
Motor and nonmotor complications in Parkinson’s disease: an argument for continuous drug delivery?
Chaudhuri, К. R., Rizos, A., & Sethi, K. D. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-0981-5 · Cited by 104
Quantitative Analysis of Neurochemical Panel in Rat Brain and Plasma by Liquid Chromatography–Tandem Mass Spectrometry
Zheng, X., An, K., Dai, C., Liang, Y. L., Xie, T., Xie, L. Y., Peng, Y., Wang, G., & Hao, H. (2012) · Analytical Chemistry · doi:10.1021/ac3025202 · Cited by 105
A review of the role of serotonin system genes in obsessive-compulsive disorder
Sinopoli, V. M., Burton, C. L., Kronenberg, S., & Arnold, P. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.029 · Cited by 107
Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal
Kaufling, J., & Aston‐Jones, G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0715-15.2015 · Cited by 89
Prospect of a Dopamine Contribution in the Next Generation of Antidepressant Drugs: The Triple Reuptake Inhibitors
Guiard, B. P., Mansari, M. E., & Blier, P. (2009) · Current Drug Targets · doi:10.2174/138945009789735156 · Cited by 99
Emotional dysfunction in Parkinson's disease.
Blonder, L. X., & Slevin, J. T. (2011) · PubMed Central · doi:10.3233/ben-2011-0329 · Cited by 86
Light-sensitive brain pathways and aging
Daneault, V., Dumont, M., Massé, É., Vandewalle, G., & Carrier, J. (2016) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-016-0091-9 · Cited by 86
Current animal models of obsessive compulsive disorder: an update
Albelda, N., & Joel, D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.070 · Cited by 85
Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies
Nikolic, K. M., Mavridis, L., Djikić, T., Vučićević, J., Agbaba, D. D., Yelekçi, K., & Mitchell, J. B. O. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00265 · Cited by 79
Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures
Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V., & Giovanni, G. D. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.016 · Cited by 72
Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission
Polter, A. M., & Li, X. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00031 · Cited by 70
Polypharmacology of dopamine receptor ligands
Butini, S., Nikolic, K. M., Kassel, S., Brückmann, H., Filipić, S., Agbaba, D. D., Gemma, S., Brogi, S., Brindisi, M., Campiani, G., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.011 · Cited by 69
Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons
Scheunemann, L., Plaçais, P.-Y., Dromard, Y., Schwärzel, M., & Préat, T. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.032 · Cited by 72
The Formation and Function of the VTA Dopamine System
Hou, G., Hao, M., Duan, J., & Han, M.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073875 · Cited by 65
L-DOPA-induced dysregulation of extrastriatal dopamine and serotonin and affective symptoms in a bilateral rat model of Parkinson’s disease
Jaunarajs, K. L. E., George, J. A., & Bishop, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.052 · Cited by 65
The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism
Haduch, A., Bromek, E., Kuban, W., & Daniel, W. A. (2023) · Metabolites · doi:10.3390/metabo13050629 · Cited by 63
Serotonin excites fast‐spiking interneurons in the striatum
Blomeley, C. P., & Bracci, E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06725.x · Cited by 62
Aging Reduces the Stimulating Effect of Blue Light on Cognitive Brain Functions
Daneault, V., Hébert, M., Albouy, G., Doyon, J., Dumont, M., Carrier, J., & Vandewalle, G. (2014) · SLEEP · doi:10.5665/sleep.3314 · Cited by 64
Increased local dopamine secretion has growth‐promoting effects in cholangiocarcinoma
Coufal, M., Invernizzi, P., Gaudio, E., Bernuzzi, F., Frampton, G. A., Onori, P., Franchitto, A., Carpino, G., Ramirez, J. C., Alvaro, D., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24909 · Cited by 60
The Role of the Striatum in Compulsive Behavior in Intact and Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System
Schilman, E. A., Klavir, O., Winter, C., Sohr, R., & Joel, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.208 · Cited by 55
Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism
Delaville, C., Navailles, S., & Benazzouz, A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.024 · Cited by 55
Running Reduces Uncontrollable Stress-Evoked Serotonin and Potentiates Stress-Evoked Dopamine Concentrations in the Rat Dorsal Striatum
Clark, P., Amat, J., McConnell, S. O., Ghasem, P. R., Greenwood, B. N., Maier, S. F., & Fleshner, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141898 · Cited by 53
Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity
Varga, G., Székely, A., Antal, P., Sárközy, P., Nemoda, Z., Demetrovics, Z., & Sasvári‐Székely, M. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32025 · Cited by 52
A Review of Transcranial Magnetic Stimulation in Vascular Dementia
Pennisi, G., Ferri, R., Cantone, M., Lanza, G., Pennisi, M., Vinciguerra, L., Malaguarnera, G., & Bella, R. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000322798 · Cited by 51
5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy
Demireva, E. Y., Suri, D., Morelli, E., Mahadevia, D., Chuhma, N., Teixeira, C. M., Ziolkowski-Blake, A., Hersh, M. A., Fifer, J. E., Bagchi, S., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0227-x · Cited by 52
Role(s) of the 5‐ HT 2C Receptor in the Development of Maximal Dentate Activation in the Hippocampus of Anesthetized Rats
Orbán, G., Bombardi, C., Marino, A., Colangeli, R., Pierucci, M., Pomara, C., Pessia, M., Bucchieri, F., Benigno, A., Smolders, I. J., et al. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12285 · Cited by 46
Self-citation
The engagement of brain cytochrome P450 in the metabolism of endogenous neuroactive substrates: a possible role in mental disorders
Haduch, A., & Daniel, W. A. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1554674 · Cited by 45
Restless legs syndrome: Over 50 years of E uropean contribution
Khachatryan, S. G., Ferri, R., Fulda, S., Garcı́a-Borreguero, D., Manconi, M., Muntean, M., & Stefani, A. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13632 · Cited by 41
An extended reinforcement learning model of basal ganglia to understand the contributions of serotonin and dopamine in risk-based decision making, reward prediction, and punishment learning
Balasubramani, P. P., Chakravarthy, V. S., Ravindran, B., & Moustafa, A. A. (2014) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2014.00047 · Cited by 44
5-HT1A receptor-dependent control of nigrostriatal dopamine neurotransmission in the pharmacotherapy of Parkinson’s disease and schizophrenia
Haleem, D. J. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000123 · Cited by 41
Increased excitability in serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease
Prinz, A., Selesnew, L.-M., Liss, B., Roeper, J., & Carlsson, T. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.015 · Cited by 38
The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B. H., Woody, E. Z., & Hoffman, K. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 41
The dopaminergic system and Alzheimer’s disease
Zhang, Y., Liang, Y., & Gu, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00230 · Cited by 47
Differential behavioural and neurochemical outcomes from chronic paroxetine treatment in adolescent and adult rats: a model of adverse antidepressant effects in human adolescents?
Karanges, E. A., Li, K. M., Motbey, C. P., Callaghan, P. D., Katsifis, A. G., & McGregor, I. S. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571100006x · Cited by 39
The cytochrome P450 2D‐mediated formation of serotonin from 5‐methoxytryptamine in the brainin vivo: a microdialysis study
Haduch, A., Bromek, E., Kot, M., Kamińska, K., Gołembiowska, K., & Daniel, W. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13031 · Cited by 38
Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
Haduch, A., Bromek, E., Wójcikowski, J., Gołembiowska, K., & Daniel, W. A. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.067413 · Cited by 38
Cerebrospinal fluid levels of monoamines among suicide attempters: A systematic review and random-effects meta-analysis
Hoertel, N., Cipel, H., Blanco, C., Oquendo, M. A., Ellul, P., Leaune, É., Limosin, F., Peyre, H., & Costemale-Lacoste, J.-F. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.01.045 · Cited by 37
HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory
Drago, A., Alboni, S., Brunello, N., Ronchi, D. D., & Serretti, A. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0724-6 · Cited by 36
Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of 2 J monoaminergic neurons
Katz, N., Guiard, B. P., Mansari, M. E., & Blier, P. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109348178 · Cited by 35
Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
Li, H., Liu, Y., Xing, L., Yang, X., Xu, J., Ren, Q., Su, K., Lu, Y., & Wang, F. (2020) · Nature and Science of Sleep · doi:10.2147/nss.s272883 · Cited by 36
Impact of Serotonin (5-HT)2C Receptors On Executive Control Processes
Pennanen, L., van der Hart, M., Yu, L., & Tecott, L. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.258 · Cited by 33
Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults
Sternat, T., Fotinos, K., Fine, A., Epstein, I., & Katzman, M. A. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s170645 · Cited by 33
Can 5-HT3 antagonists contribute toward the treatment of schizophrenia?
Ellenbroek, B. A., & Prinssen, E. P. M. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000102 · Cited by 29
Purposeless oral activity induced by meta-chlorophenylpiperazine (m-CPP): Undefined tic-like behaviors?
Kreiss, D. S., & Deurwaerdère, P. D. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.05.007 · Cited by 28
Involvement of the dopamine D1 receptor system in the anxiolytic effect of cedrol in the elevated plus maze and light–dark box tests
Zhang, K., Lu, J., & Yao, L. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.11.004 · Cited by 27
Serotonin/Dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout
Hall, F. S., Sora, I., Hen, R., & Uhl, G. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115009 · Cited by 28
Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
Dombrovski, A. Y., Mulsant, B. H., Ferrell, R. E., Lotrich, F. E., Rosen, J., Wallace, M. J., Houck, P. R., Mazumdar, S., & Pollock, B. G. (2009) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328333ee10 · Cited by 25
A mutation in monoamine oxidase (MAO) affects the evolution of stress behavior in the blind cavefish Astyanax mexicanus
Pierre, C., Pradère, N., Froc, C., Ornelas‐García, C. P., Callebert, J., & Rétaux, S. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.226092 · Cited by 25
Effect of paroxetine and bupropion on human resting brain perfusion: An arterial spin labeling study
Viviani, R., Abler, B., Seeringer, A., & Stingl, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.014 · Cited by 26
Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating
Brownley, K. A., Boettiger, C. A., Young, L., & Cefalu, W. T. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.03.020 · Cited by 26
Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement
Fletcher, P. J., Sinyard, J., & Higgins, G. A. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.07.002 · Cited by 25
Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive–Compulsive Disorder Patients’ Subgroups
Melo-Felippe, F. B., Andrade, J. B. D. S., Giori, I. G., Vieira-Fonseca, T., Fontenelle, L. F., & Kohlrausch, F. B. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0697-0 · Cited by 28
Oral administration of 5‐hydroxytryptophan (5‐HTP) impairs decision making under ambiguity but not under risk: evidence from the Iowa Gambling Task
Gendle, M. H., & Golding, A. C. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1139 · Cited by 24
Context-Dependent Effects of a Single Administration of Mirtazapine on the Expression of Methamphetamine-Induced Conditioned Place Preference
Voigt, R. M., & Napier, T. C. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00092 · Cited by 23
Predicting targets of compounds against neurological diseases using cheminformatic methodology
Nikolic, K. M., Mavridis, L., Bautista‐Aguilera, Ó. M., Marco‐Contelles, J., Stark, H., Carreiras, M. C., Rossi, I., Massarelli, P., Agbaba, D. D., Ramsay, R. R., et al. (2014) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-014-9816-1 · Cited by 22
Leg movements during sleep in children treated with serotonergic antidepressants
Ferri, R., Mogavero, M. P., Bruni, O., Picchietti, D. L., Kapoor, V., & DelRosso, L. M. (2021) · SLEEP · doi:10.1093/sleep/zsab236 · Cited by 22
Hippocampal protein expression is differentially affected by chronic paroxetine treatment in adolescent and adult rats: a possible mechanism of “paradoxical” antidepressant responses in young persons
Karanges, E. A., Kashem, M., Sarker, R., Ahmed, E. U., Ahmed, S., van Nieuwenhuijzen, P. V., Kemp, A., & McGregor, I. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00086 · Cited by 24
Bidirectional role of dopamine in learning and memory-active forgetting
Díaz, F. C., Caffino, L., & Fumagalli, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.011 · Cited by 24
Direct serotonin release in humans shapes aversive learning and inhibition
Colwell, M., Tagomori, H., Shang, F., Cheng, H. I., Wigg, C., Browning, M. D., Cowen, P. J., Murphy, S. E., & Harmer, C. J. (2024) · Nature Communications · doi:10.1038/s41467-024-50394-x · Cited by 21
Understanding Anhedonia: The Role of Perceived Control
MacAulay, R. K., McGovern, J. E., & Cohen, A. S. (2014) · Springer eBooks · doi:10.1007/978-94-017-8591-4_2 · Cited by 19
Acute Stress Exposure Alters Food-Related Brain Monoaminergic Profiles in a Rat Model of Anorexia
Reed, C. H., Bauer, E. E., Shoeman, A., Buhr, T. J., & Clark, P. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab298 · Cited by 19
Abnormal Development of Monoaminergic Neurons Is Implicated in Mood Fluctuations and Bipolar Disorder
Jukić, M. M., Carrillo‐Roa, T., Bar, M., Becker, G., Jovanovic, V. M., Zega, K., Binder, E. B., & Brodski, C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.244 · Cited by 20
Effect of Caffeine on Endurance Performance in Athletes May Depend on HTR2A and CYP1A2 Genotypes
Guest, N. S., Corey, P., Tyrrell, P. N., & El‐Sohemy, A. (2020) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003665 · Cited by 19
Access to the CNS: Biomarker Strategies for Dopaminergic Treatments
van den Brink, W. J., Palić, S., Köhler, I., & de Lange, E. C. M. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2333-x · Cited by 18
Multimodal investigation of dopamine D2/D3 receptors, default mode network suppression, and cognitive control in cocaine-use disorder
Worhunsky, P. D., Angarita, G. A., Zhai, Z. W., Matuskey, D., Gallezot, J., Malison, R. T., Carson, R. E., & Potenza, M. N. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00874-7 · Cited by 18
Effects of Social Isolation on 50-kHz Ultrasonic Vocalizations, Affective State, Cognition, and Catecholamine Concentrations in the Ventral Tegmental and Locus Coeruleus of Adult RatsPreprint
Broadfoot, C. K., Lenell, C., Kelm‐Nelson, C. A., & Ciucci, M. R. (2022) · SSRN Electronic Journal · doi:10.1016/j.bbr.2022.114157 · Cited by 15
Antipsychotics and the Dopamine–Serotonin Connection
Ellenbroek, B. A., & Cesura, A. M. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_51 · Cited by 16
An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster
Zárate, R. V., Hidalgo, S., Navarro, N., Molina‐Mateo, D., Arancibia, D., Rojo-Cortés, F., Oliva, C., Andrés, M. E., Zamorano, P. L., & Campusano, J. M. (2022) · Cells · doi:10.3390/cells11091544 · Cited by 15
The h-Current in the Substantia Nigra pars Compacta Neurons: A Re-examination
Gambardella, C., Pignatelli, A., & Belluzzi, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052329 · Cited by 15
Antidepressants and Adolescent Brain Development
Karanges, E. A., & McGregor, I. S. (2011) · Future Neurology · doi:10.2217/fnl.11.51 · Cited by 16
Obsessive compulsive disorder (OCD): Current treatments and a framework for neurotherapeutic research
Woody, E. Z., Hoffman, K. L., & Szechtman, H. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.003 · Cited by 16
The Effect of Chromium Nanoparticles and Chromium Picolinate in the Diet of Chickens on Levels of Selected Hormones and Tissue Antioxidant Status
Stępniowska, A., Drażbo, A. A., Kozłowski, K., Ognik, K., & Jankowski, J. (2019) · Animals · doi:10.3390/ani10010045 · Cited by 15
Imbalance between dopamine and serotonin caused by neonatal habenula lesion
Lee, Y., Kim, Y., Lee, J., Lee, S., & Goto, Y. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113316 · Cited by 14
Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems
Mansari, M. E., Crnic, A., Oosterhof, C. A., & Blier, P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.007 · Cited by 14
Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate
Fletcher, P. J., Zeeb, F. D., Browne, C. J., Higgins, G. A., & Soko, A. D. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4529-5 · Cited by 14
The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females
Castle, M., & Flanigan, M. E. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100618 · Cited by 13
Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson’s Disease
Marino, G., Campanelli, F., Natale, G., Carluccio, M. D., Servillo, F., Ghiglieri, V., & Calabresi, P. (2025) · Current Neuropharmacology · doi:10.2174/011570159x336597241217062042 · Cited by 14
Path Integral Calculation of the Hydrogen/Deuterium Kinetic Isotope Effect in Monoamine Oxidase A-Catalyzed Decomposition of Benzylamine
Brela, M. Z., Prah, A., Boczar, M., Stare, J., & Mavri, J. (2019) · Molecules · doi:10.3390/molecules24234359 · Cited by 13
In Vivo Microdialysis in Parkinson’s Research
Giovanni, G. D., Esposito, E., & Matteo, V. D. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_18 · Cited by 12
Self-citation
Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy
Boulougouris, V., Malogiannis, I. A., Lockwood, G., Zervas, I. M., & Giovanni, G. D. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3669-z · Cited by 11
Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment
Igari, M., Shen, H., Hagino, Y., Fukushima, S., Kasahara, Y., Lesch, K., Murphy, D. L., Hall, F. S., Uhl, G. R., Ikeda, K., et al. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000120 · Cited by 12
Quand la saison devient synonyme de dépression
Gagné, A.-M., Bouchard, G., Tremblay, P., Sasseville, A., & Hébert, M. (2010) · médecine/sciences · doi:10.1051/medsci/201026179 · Cited by 11
Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats
Deurwaerdère, P. D., Casarrubea, M., Cassar, D., Radic, M., Puginier, E., Chagraoui, A., Crescimanno, G., Crunelli, V., & Giovanni, G. D. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.886033 · Cited by 10

Authors: DIGIOVANNI, G., DIMATTEO, V, PIERUCCI, M., & ESPOSITO, E.
Affiliations: Mario Negri Institute for Pharmacological Research (IT)
Corresponding author: ESPOSITO, E
ORCID: PIERUCCI, M
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2008
Volume: 172
Pages: 45-71
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(08)00903-5
OpenAlex: W1554279409
Cited by: 151
References: 153
Citations by year: 2026: 7 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 10 · 2012: 10
FWCI: 12.85
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: serotonin-dopamine interaction, serotonin, dopaminergic neurons, raphe nuclei, ventral tegmental area, substantia nigra pars compacta, serotonin receptors, GABAergic input, glutamatergic input, neuropsychiatric disorders, subtype-selective ligands
MeSH terms: Animals, Brain, Dopamine, Electric Stimulation, Electrophysiology, Neural Pathways, Neurons, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Serotonin Receptor Agonists, Selective Serotonin Reuptake Inhibitors, Dopamine Agonists, Dopamine Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Serotonin–dopamine interaction: electrophysiological evidence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks