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Serotonin–dopamine interaction: electrophysiological evidence

DIGIOVANNI, G, DIMATTEO, V, PIERUCCI, M, ESPOSITO, E·2008·Progress in Brain Research

DOI 10.1016/s0079-6123(08)00903-5

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Abstract

In this review, the most relevant data regarding serotonin (5-hydroxytryptamine, 5-HT)/dopamine (DA) interaction in the brain, as studied by both in vivo and in vitro electrophysiological methods, are reported and discussed. The bulk of neuroanatomical data available clearly indicate that DA-containing neurons in the brain receive a prominent innervation from 5-HT originating in the raphe nuclei of the brainstem. Furthermore, this modulation seems to be reciprocal; DA neurons innervate the raphe nuclei and exert a tonic excitatory effect on them. Compelling electrophysiological data show that 5-HT can exert complex effects on the electrical activity of midbrain DA neurons mediated by the various receptor subtypes. The main control seems to be inhibitory, this effect being more marked in the ventral tegmental area (VTA) as compared to the substantia nigra pars compacta (SNc). In spite of a direct effect of 5-HT by its receptors located on DA cells, 5-HT can modulate their activity indirectly, modifying gamma-amino-n-butyric acid (GABA)-ergic and glutamatergic input to the VTA and SNc. Although 5-HT/DA interaction in the brain has been extensively studied, much work remains to be done to clarify this issue. The recent development of subtype-selective ligands for 5-HT receptors will not only allow a detailed understanding of this interaction but also lead to development of new treatment strategies, appropriate for those neuropsychiatric disorders in which an alteration of the 5-HT/DA balance is supposed.

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Authors: DIGIOVANNI, G., DIMATTEO, V, PIERUCCI, M., & ESPOSITO, E.
Affiliations: Mario Negri Institute for Pharmacological Research (IT)
Corresponding author: ESPOSITO, E
ORCID: PIERUCCI, M
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2008
Volume: 172
Pages: 45-71
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(08)00903-5
OpenAlex: W1554279409
Cited by: 151
References: 153
Citations by year: 2026: 7 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 10 · 2012: 10
FWCI: 12.85
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: serotonin-dopamine interaction, serotonin, dopaminergic neurons, raphe nuclei, ventral tegmental area, substantia nigra pars compacta, serotonin receptors, GABAergic input, glutamatergic input, neuropsychiatric disorders, subtype-selective ligands
MeSH terms: Animals, Brain, Dopamine, Electric Stimulation, Electrophysiology, Neural Pathways, Neurons, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Serotonin Receptor Agonists, Selective Serotonin Reuptake Inhibitors, Dopamine Agonists, Dopamine Antagonists

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Serotonin–dopamine interaction: electrophysiological evidence

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