Modeling excess striatal D2 receptors in mice
Abstract
Dopaminergic hyperactivity in the striatum has been one of the most replicated physiological findings in patients with schizophrenia. To study the consequences of increased D2 receptor density in the striatum, as it has been observed in patients with schizophrenia, D2 receptors have been selectively over-expressed in the mouse striatum. Here, the analysis of this mouse model is summarized and discussed in the context of the dopamine hypothesis of schizophrenia.
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Overexpression of D2 receptors similar to that seen in some individuals with schizophrenia will alter striatal MSN activity, resulting in dysregulated GABA transmission and inhibitory activity in the cortex.
“Taken together, the mouse model suggests that overexpression of D2 receptors (similar to that seen in some individuals with schizophrenia) will alter striatal MSN activity, resulting in dysregulated GABA transmission and inhibitory activity in the cortex [380].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [380]
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Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
- Authors
- Kellendonk, C.
- Affiliations
- Columbia University (US)
- Corresponding author
- Kellendonk, Christoph
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2009
- Volume
- 179
- Pages
- 59-65
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W16486403
- Cited by
- 10
- References
- 27
- Citations by year
- 2025: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 4.99
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D2 receptor, striatum, mouse model, schizophrenia, dopamine hypothesis of schizophrenia, dopaminergic hyperactivity, receptor density
- MeSH terms
- Animals, Brain Chemistry, Cerebral Cortex, Corpus Striatum, Disease Models, Animal, Dopamine, Humans, Schizophrenia, Up-Regulation, Receptors, Dopamine D2, Mice
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