Cited by 1,068Schizophrenia research and treatmentNeural and Behavioral Psychology StudiesCognitive Abilities and Testing

Working memory dysfunction in schizophrenia

Patricia S. Goldman‐Rakic·1994·The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Recent advances in anatomical, behavioral, and physiological techniques have produced new information about the nature of prefrontal function, its cellular basis, and its anatomical underpinnings in nonhuman primates. These findings are changing our views of prefrontal function and providing insight into possible bases for human mental disorder. A major advance is the recognition that various prefrontal areas are engaged in holding information "on line" and updating past and current information on a moment-to-moment basis. Studies of animals and of cognitive function in normal, brain-injured, and schizophrenic subjects support the theory that a defect in working memory--the ability to guide behavior by representations--may be the fundamental impairment leading to schizophrenic thought disorder.

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Crossref · 10.1176/jnp.6.4.348

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Authors
Goldman‐Rakic, P. S.
Affiliations
Yale University (US)
Corresponding author
Patricia S. Goldman‐Rakic
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Published
1994-11-01
Volume
6
Issue
4
Pages
348-357
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
OpenAlex
W2043941998
Cited by
1,068
References
49
Citations by year
2026: 9 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 20 · 2021: 21 · 2020: 18 · 2019: 50 · 2018: 29 · 2017: 37 · 2016: 30 · 2015: 50 · 2014: 31 · 2013: 60 · 2012: 48
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
working memory, schizophrenia, prefrontal cortex, thought disorder, cognitive impairment, non-human primates, brain injury, mental representation, prefrontal function
MeSH terms
Animals, Brain Mapping, Frontal Lobe, Humans, Neuropsychological Tests, Mental Recall, Retention, Psychology, Schizophrenia, Schizophrenic Psychology, Thinking, Prefrontal Cortex

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