Working memory dysfunction in schizophrenia
Abstract
Recent advances in anatomical, behavioral, and physiological techniques have produced new information about the nature of prefrontal function, its cellular basis, and its anatomical underpinnings in nonhuman primates. These findings are changing our views of prefrontal function and providing insight into possible bases for human mental disorder. A major advance is the recognition that various prefrontal areas are engaged in holding information "on line" and updating past and current information on a moment-to-moment basis. Studies of animals and of cognitive function in normal, brain-injured, and schizophrenic subjects support the theory that a defect in working memory--the ability to guide behavior by representations--may be the fundamental impairment leading to schizophrenic thought disorder.
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Schizophrenia involves a severe deficit in working memory.
“with a severe deficit in working memory (WM), the ability to transiently maintain and manipulate information internally (Goldman-Rakic 1994;Lee and Park 2005).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Goldman-Rakic 1994
Cites
(2007) · Cognitive Psychology · doi:10.4135/9781446212967.n15 · Cited by 3,749 · see citing works
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741 · see citing works
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685 · see citing works
Self-citationEffects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
MILNER, B. (1963) · Archives of Neurology · doi:10.1001/archneur.1963.00460070100010 · Cited by 2,217 · see citing works
Society for Neuroscience 2007 abstracts
Wishart, T. M., Paterson, J. M., Short, D. M., Meredith, S., Robertson, K., Sutherland, C. D., Cousin, M. A., Dutia, M. B., & Gillingwater, T. H. (2007) · Cited by 2,094 · see citing works
Neuron Activity Related to Short-Term Memory
Fuster, J. M., & Alexander, G. E. (1971) · Science · doi:10.1126/science.173.3997.652 · Cited by 2,085 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,019 · see citing works
Topography Of Cognition: Parallel Distributed Networks In Primate Association Cortex
Goldman‐Rakic, P. S. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.001033 · Cited by 1,662 · see citing works
Self-citationDissociation of object and spatial processing domains in primate prefrontal cortex.
Wilson, F. A., Scalaidhe, S. P. Ó., & Goldman-Rakic, P. (1993) · Science · doi:10.1126/science.8316836 · Cited by 1,374 · see citing works
Self-citationDeficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
Petrides, M., & Milner, B. A. (1982) · Neuropsychologia · doi:10.1016/0028-3932(82)90100-2 · Cited by 1,272 · see citing works
Cavada, C., & Goldman, P. S. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902870403 · Cited by 1,127 · see citing works
Perret, E. (1974) · Neuropsychologia · doi:10.1016/0028-3932(74)90047-5 · Cited by 1,007 · see citing works
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 946 · see citing works
Spatial memory and hippocampal function
Olton, D. S., & Paras, B. C. (1979) · Neuropsychologia · doi:10.1016/0028-3932(79)90042-3 · Cited by 927 · see citing works
Selemon, L. D., & Goldman-Rakic, P. S. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04049.1988 · Cited by 908 · see citing works
Self-citationHypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic Schizophrenia
Andreasen, N. C. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120031006 · Cited by 883 · see citing works
Cavada, C., & Goldman, P. S. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902870402 · Cited by 791 · see citing works
Goldman‐Rakic, P. S., Selemon, L. D., & Schwartz, M. L. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90166-0 · Cited by 782 · see citing works
Self-citationPrefrontal cortical unit activity and delayed alternation performance in monkeys.
Kubota, K., & Niki, H. (1971) · Journal of Neurophysiology · doi:10.1152/jn.1971.34.3.337 · Cited by 717 · see citing works
Prefrontal neuronal activity in rhesus monkeys performing a delayed anti-saccade task
Funahashi, S., Chafee, M. V., & Goldman, P. S. (1993) · Nature · doi:10.1038/365753a0 · Cited by 662 · see citing works
Frontal Granular Cortex and Behavior.
Orbach, J. (1964) · Archives of General Psychiatry · doi:10.1001/archpsyc.1964.01720300109016 · Cited by 626 · see citing works
Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey
Goldman, P. S., & Rosvold, H. E. (1970) · Experimental Neurology · doi:10.1016/0014-4886(70)90222-0 · Cited by 581 · see citing works
Kolb, B. E., & Whishaw, I. Q. (1983) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198307000-00008 · Cited by 464 · see citing works
Prefrontal connections of medial motor areas in the rhesus monkey
Bates, J. F., & Goldman, P. S. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903360205 · Cited by 432 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Berman, K. F. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020032005 · Cited by 417 · see citing works
Behavioural effects of frontal-lobe lesions in man
Milner, B. A., & Petrides, M. (1984) · Trends in Neurosciences · doi:10.1016/s0166-2236(84)80143-5 · Cited by 386 · see citing works
Goldman, P. S., Rosvold, H. E., Vest, B., & Galkin, T. W. (1971) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0031649 · Cited by 381 · see citing works
Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders
Buchsbaum, M. S. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790230045007 · Cited by 369 · see citing works
Psychological deficit in schizophrenia
Shakow, D. (2007) · Systems Research and Behavioral Science · doi:10.1002/bs.3830080402 · Cited by 343 · see citing works
CORRELATES OF IMPAIRED ORIENTATION IN PERSONAL AND EXTRAPERSONAL SPACE
Semmes, J., Weinstein, S., GHENT, G., Meyer, J. S., & Teuber, H. (1963) · Brain · doi:10.1093/brain/86.4.747 · Cited by 314 · see citing works
Frontal lobe dysfunctions in schizophrenia—I. Eye movement impairments
Levin, S. (1984) · Journal of Psychiatric Research · doi:10.1016/0022-3956(84)90046-3 · Cited by 258 · see citing works
Brain Electrical Activity Mapping (BEAM) in Schizophrenic Patients
Morihisa, J. M. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790060017002 · Cited by 245 · see citing works
Squire, L. (1984) · Neurobiology of Learning and Memory · Cited by 234 · see citing works
Regional Brain Glucose Metabolism in Chronic Schizophrenia
Farkas, T. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790140083010 · Cited by 233 · see citing works
Hippocampal unit activity and delayed response in the monkey
Watanabe, T., & Niki, H. (1985) · Brain Research · doi:10.1016/0006-8993(85)90320-8 · Cited by 230 · see citing works
The Disorder of Consciousness in Schizophrenia
Anscombe, R. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.241 · Cited by 225 · see citing works
Friedman, H., & Goldman-Rakic, P. S. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04693.1988 · Cited by 210 · see citing works
Self-citationFrontal lobe dysfunctions in schizophrenia—II. impairments of psychological and brain functions
Levin, S. (1984) · Journal of Psychiatric Research · doi:10.1016/0022-3956(84)90047-5 · Cited by 199 · see citing works
Goldman, P. S., & Nauta, W. J. H. (1976) · Brain Research · doi:10.1016/0006-8993(76)90256-0 · Cited by 170 · see citing works
McGuire, P. K., Bates, J. F., & Goldman‐Rakic, P. S. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.5.408 · Cited by 163 · see citing works
Self-citationJudgment of Visual and Postural Vertical After Brain Injury
Teuber, H., & Mishkin, M. M. (1954) · The Journal of Psychology · doi:10.1080/00223980.1954.9712927 · Cited by 117 · see citing works
Absence of activation in frontal structures during psychological testing of chronic schizophrenics.
FRANZÉN, G., & Ingvar, D. H. (1975) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.38.10.1027 · Cited by 117 · see citing works
Vérin, M., Partiot, A., Pillon, B., Malapani, C., Agid, Y., & Dubois, B. (1993) · Neuropsychologia · doi:10.1016/0028-3932(93)90105-9 · Cited by 109 · see citing works
McGuire, P. K., Bates, J. F., & Goldman‐Rakic, P. S. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.5.390 · Cited by 106 · see citing works
Self-citationThe Prefrontal Cortex and Temporal Integration
Fuster, J. M. (1985) · Cerebral cortex · doi:10.1007/978-1-4757-9619-3_4 · Cited by 76 · see citing works
Kitchener, P. D., & Diamond, J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903350102 · Cited by 61 · see citing works
Delayed alternation performance in patients with cerebral lesions
Chorover, S. L., & Cole, M. (1966) · Neuropsychologia · doi:10.1016/0028-3932(66)90016-9 · Cited by 36 · see citing works
An Hypothesis about Schizophrenic Behavior
Salzinger, K. (1971) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1971.25.4.601 · Cited by 26 · see citing works
A Parallel Distributed Processing Approach to Behavior and Biology in Schizophrenia
Cohen, J. D., & Servan‐Schreiber, D. (1989) · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies.
Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005) · Human Brain Mapping · doi:10.1002/hbm.20131 · Cited by 3,560 · see citing works
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736 · see citing works
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610 · see citing works
Schizophrenia, consciousness, and the self
Sass, L. A., & Parnas, J. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007017 · Cited by 1,324 · see citing works
Identification of separable cognitive factors in schizophrenia
Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.007 · Cited by 1,304 · see citing works
Compte, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.9.910 · Cited by 1,143 · see citing works
Synaptic reverberation underlying mnemonic persistent activity
Wang, X.-J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01868-3 · Cited by 1,059 · see citing works
Mind reading: Neural mechanisms of theory of mind and self-perspective
Vogeley, K., Bussfeld, P., Newen, A., Herrmann, S., Happé, F., Falkai, P., Maier, W., Shah, N. J., Fink, G. R., & Zilles, K. (2001) · NeuroImage · doi:10.1006/nimg.2001.0789 · Cited by 998 · see citing works
Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.
De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., & Ryan, N. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00045-1 · Cited by 974 · see citing works
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938 · see citing works
Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory
Wang, X.-J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09587.1999 · Cited by 859 · see citing works
Schizophrenia, dopamine and the striatum: From biology to symptoms
McCutcheon, R. A., Abi-Dargham, A., & Howes, O. D. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.004 · Cited by 763 · see citing works
Prefrontal Dopamine D<sub>1</sub>Receptors and Working Memory in Schizophrenia
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.-R., Keilp, J., Kochan, L., Van Heertum, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03708.2002 · Cited by 724 · see citing works
Javitt, D. C., Steinschneider, M., Schroeder, C. E., & Arezzo, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11962 · Cited by 662 · see citing works
Brunel, N., & Wang, X.-J. (2001) · Journal of Computational Neuroscience · doi:10.1023/a:1011204814320 · Cited by 620 · see citing works
Dendritic spine pathology in schizophrenia
Glausier, J. R., & Lewis, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.044 · Cited by 581 · see citing works
Working memory in schizophrenia: a meta-analysis
Forbes, N. F., Carrick, L. A., McIntosh, A. M., & Lawrie, S. M. (2009) · Psychological Medicine · doi:10.1017/s0033291708004558 · Cited by 550 · see citing works
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
Heckers, S., Rauch, S., Goff, D., Savage, C., Schacter, D., Fischman, A., & Alpert, N. (1998) · Nature Neuroscience · doi:10.1038/1137 · Cited by 570 · see citing works
Changes in cortical dopamine D1 receptor binding associated with cognitive training
McNab, F., Varrone, A., Farde, L., Jucaite, A., Bystritsky, P., Forssberg, H., & Klingberg, T. (2009) · Science · doi:10.1126/science.1166102 · Cited by 545 · see citing works
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540 · see citing works
Training of Working Memory Impacts Structural Connectivity
Takeuchi, H., Sekiguchi, A., Taki, Y., Yokoyama, S., Yomogida, Y., Komuro, N., Yamanouchi, T., Suzuki, S., & Kawashima, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4611-09.2010 · Cited by 531 · see citing works
De Bellis, M. D. (2005) · Child Maltreatment · doi:10.1177/1077559505275116 · Cited by 531 · see citing works
Kellendonk, C., Simpson, E. H., Polan, H. J., Malleret, G., Vronskaya, S., Winiger, V., Moore, H., & Kandel, E. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.023 · Cited by 520 · see citing works
Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K., & Lewis, D. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002011 · Cited by 490 · see citing works
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.012 · Cited by 494 · see citing works
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489 · see citing works
A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia
Simpson, E. H., Kellendonk, C., & Kandel, E. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.014 · Cited by 478 · see citing works
Hashimoto, T., Bazmi, H. H., Mirnics, K., Wu, Q., Sampson, A. R., & Lewis, D. A. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07081223 · Cited by 457 · see citing works
Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.09.012 · Cited by 457 · see citing works
Neurobiology of Dopamine in Schizophrenia
Guillin, O., Abi‐Dargham, A., & Laruelle, M. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78001-1 · Cited by 365 · see citing works
Early-stage visual processing and cortical amplification deficits in schizophrenia
Butler, P. D., Zemon, V., Schechter, I., Saperstein, A. M., Hoptman, M. J., Lim, K. O., Revheim, N., Silipo, G., & Javitt, D. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.495 · Cited by 362 · see citing works
Karlsgodt, K. H., van Erp, T. G. M., Poldrack, R. A., Bearden, C. E., Nuechterlein, K. H., & Cannon, T. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.017 · Cited by 335 · see citing works
The Physiological Role of 5-HT<sub>2A</sub>Receptors in Working Memory
Williams, G. V., Rao, S. G., & Goldman-Rakic, P. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02843.2002 · Cited by 311 · see citing works
Self-citationMeyer, U., Yee, B. K., & Feldon, J. (2007) · The Neuroscientist · doi:10.1177/1073858406296401 · Cited by 303 · see citing works
Gorelova, N., Seamans, J. K., & Yang, C. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00335.2002 · Cited by 302 · see citing works
Functional anatomical correlates of controlled and automatic processing
Jansma, J. M., Ramsey, N. F., Slagter, H. A., & Kahn, R. S. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/08989290152541403 · Cited by 281 · see citing works
Tan, H.-Y., Callicott, J. H., & Weinberger, D. R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm069 · Cited by 266 · see citing works
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255 · see citing works
Barch, D. M., Carter, C. S., MacDonald, A. W., Braver, T. S., & Cohen, J. D. (2003) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.112.1.132 · Cited by 255 · see citing works
A meta-analysis of neuroimaging studies on divergent thinking using activation likelihood estimation
Wu, X., Yang, W., Tong, D., Sun, J., Chen, Q., Wei, D., Zhang, Q., Zhang, M., & Qiu, J. (2015) · Human Brain Mapping · doi:10.1002/hbm.22801 · Cited by 250 · see citing works
Winter, C., Djodari-Irani, A., Sohr, R., Morgenstern, R., Feldon, J., Juckel, G., & Meyer, U. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009206 · Cited by 242 · see citing works
Dopamine hypothesis of schizophrenia: Making sense of it all
Toda, M., & Abi-Dargham, A. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0041-7 · Cited by 235 · see citing works
Glutamatergic model psychoses: prediction error, learning, and inference
Corlett, P. R., Honey, G. D., Krystal, J. H., & Fletcher, P. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.163 · Cited by 229 · see citing works
From prediction error to psychosis: Ketamine as a pharmacological model of delusions
Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077716 · Cited by 227 · see citing works
Haenschel, C., Bittner, R. A., Haertling, F., Rotarska-Jagiela, A., Maurer, K., Singer, W., & Linden, D. E. J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.11.1229 · Cited by 215 · see citing works
Rethinking schizophrenia in the context of normal neurodevelopment
Catts, V. S., Fung, S. J., Long, L. E., Joshi, D., Vercammen, A., Allen, K. M., Fillman, S. G., Rothmond, D. A., Sinclair, D., Tiwari, Y., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00060 · Cited by 206 · see citing works
Foxe, J. J., Murray, M. M., & Javitt, D. C. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi069 · Cited by 187 · see citing works
Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain
Sinclair, D., Purves-Tyson, T. D., Allen, K. M., & Weickert, C. S. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3415-z · Cited by 191 · see citing works
Oertel-Knöchel, V., Mehler, P., Thiel, C., Steinbrecher, K., Malchow, B., Tesky, V., Ademmer, K., Prvulovic, D., Banzer, W., Zopf, Y., et al. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0485-9 · Cited by 185 · see citing works
Seal, M., Aleman, A., & McGuire, P. (2004) · Cognitive Neuropsychiatry · doi:10.1080/13546800344000156 · Cited by 178 · see citing works
A Dynamical Systems Hypothesis of Schizophrenia
Loh, M., Rolls, E. T., & Deco, G. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030228 · Cited by 164 · see citing works
Effects of working memory training on functional connectivity and cerebral blood flow during rest
Takeuchi, H., Taki, Y., Nouchi, R., Hashizume, H., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Miyauchi, C. M., Sassa, Y., & Kawashima, R. (2013) · Cortex · doi:10.1016/j.cortex.2012.09.007 · Cited by 162 · see citing works
Regulation of NMDA Receptors by Dopamine D<sub>4</sub>Signaling in Prefrontal Cortex
Wang, X., Zhong, P., Gu, Z., & Yan, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09852.2003 · Cited by 159 · see citing works
Hashimoto, T., Nguyen, Q. L., Rotaru, D., Keenan, T., Arion, D., Beneyto, M., Gonzalez-Burgos, G., & Lewis, D. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.004 · Cited by 151 · see citing works
Schechter, I., Butler, P. D., Zemon, V. M., Revheim, N., Saperstein, A. M., Jalbrzikowski, M., Pasternak, R., Silipo, G., & Javitt, D. C. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.06.013 · Cited by 151 · see citing works
Weicker, J., Villringer, A., & Thöne-Otto, A. (2016) · Neuropsychology · doi:10.1037/neu0000227 · Cited by 147 · see citing works
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129 · see citing works
Kurtz, M. M., Ragland, J. D., Bilker, W., Gur, R. C., & Gur, R. E. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00060-8 · Cited by 134 · see citing works
Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders
Hagihara, H., Takao, K., Walton, N. M., Matsumoto, M., & Miyakawa, T. (2013) · Neural Plasticity · doi:10.1155/2013/318596 · Cited by 123 · see citing works
Hains, A. B., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.921708 · Cited by 127 · see citing works
Vuillermot, S., Joodmardi, E., Perlmann, T., Ove Ögren, S., Feldon, J., & Meyer, U. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4831-11.2012 · Cited by 127 · see citing works
Charlton, R. A., Landau, S., Schiavone, F., Barrick, T. R., Clark, C. A., Markus, H. S., & Morris, R. G. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.017 · Cited by 113 · see citing works
Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer’s disease
Ambrée, O., Richter, H., Sachser, N., Lewejohann, L., Dere, E., de Souza Silva, M. A., Herring, A., Keyvani, K., Paulus, W., & Schäbitz, W.-R. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.010 · Cited by 115 · see citing works
Kim, J. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00150-6 · Cited by 107 · see citing works
Imitation, simulation, and schizophrenia
Park, S., Matthews, N., & Gibson, C. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn048 · Cited by 99 · see citing works
The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003
Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94 · see citing works
Gamma oscillation deficits and the onset and early progression of schizophrenia
Woo, T.-U. W., Spencer, K., & McCarley, R. W. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673221003747609 · Cited by 96 · see citing works
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works
A simultaneous examination of two forms of working memory training: Evidence for near transfer only
Minear, M., Brasher, F., Guerrero, C. B., Brasher, M., Moore, A., & Sukeena, J. (2016) · Memory & Cognition · doi:10.3758/s13421-016-0616-9 · Cited by 85 · see citing works
Lencz, T., Bilder, R. M., Turkel, E., Goldman, R. S., Robinson, D., Kane, J. M., & Lieberman, J. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.3.238 · Cited by 89 · see citing works
Failure of Schizophrenia Patients to Overcome Salient Distractors During Working Memory Encoding
Hahn, B., Robinson, B. M., Kaiser, S. T., Harvey, A. N., Beck, V. M., Leonard, C. J., Kappenman, E. S., Luck, S. J., & Gold, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.014 · Cited by 88 · see citing works
Wells, E. L., Kofler, M. J., Soto, E. F., Schaefer, H. S., & Sarver, D. E. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2017.10.024 · Cited by 84 · see citing works
“…behavior (Rapport et al., 2009), inattention (Kofler et al., 2010), and mind wandering (Kane et al., 2007), and may be etiologically important for a broad range of psychopathologies including schizophrenia (Goldman-Rakic, 1994), depression (Joormann & Gotlib, 2008), and ADHD (Kasper et al., 2012).”
Adams, Z. W., Roberts, W. M., Milich, R., & Fillmore, M. T. (2011) · Psychological Assessment · doi:10.1037/a0022112 · Cited by 82 · see citing works
Dysfunction of early-stage visual processing in schizophrenia: Harmonic analysis
Kim, D., Zemon, V., Saperstein, A., Butler, P. D., & Javitt, D. C. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.10.011 · Cited by 79 · see citing works
Li, Y.-C., Kellendonk, C., Simpson, E. H., Kandel, E. R., & Gao, W.-J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109718108 · Cited by 78 · see citing works
Gesture imitation in schizophrenia
Matthews, N., Gold, B. J., Sekuler, R., & Park, S. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr062 · Cited by 74 · see citing works
Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia
Anticevic, A., Repovs, G., Corlett, P. R., & Barch, D. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.010 · Cited by 75 · see citing works
Russell, T. A., & Arcuri, S. M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00282 · Cited by 57 · see citing works
Wible, C. G. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00180 · Cited by 56 · see citing works
The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems
Fallon, J. H., Opole, I. O., & Potkin, S. G. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00022-7 · Cited by 53 · see citing works
Dissociating distractor-filtering at encoding and during maintenance.
McNab, F., & Dolan, R. J. (2014) · Journal of Experimental Psychology: Human Perception and Performance · doi:10.1037/a0036013 · Cited by 49 · see citing works
Working memory impairments in first-episode psychosis and chronic schizophrenia
Zanello, A., Curtis, L., Badan Bâ, M., & Merlo, M. C. G. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2007.10.006 · Cited by 54 · see citing works
A new dimension of sensory dysfunction: stereopsis deficits in schizophrenia
Schechter, I., Butler, P. D., Jalbrzikowski, M., Pasternak, R., Saperstein, A. M., & Javitt, D. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.064 · Cited by 53 · see citing works
Intentional inhibition in memory and hallucinations: Directed forgetting and updating.
Soriano, M. F., Jiménez, J. F., Román, P., & Bajo, M. T. (2009) · Neuropsychology · doi:10.1037/a0013739 · Cited by 47 · see citing works
Impaired magnocellular/dorsal stream activation predicts impaired reading ability in schizophrenia
Martínez, A., Revheim, N., Butler, P. D., Guilfoyle, D. N., Dias, E. C., & Javitt, D. C. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2012.09.006 · Cited by 45 · see citing works
Psychometrically matched visual-processing tasks in schizophrenia spectrum disorders
Brenner, C. A., Wilt, M. A., Lysaker, P. H., Koyfman, A., & O'Donnell, B. F. (2003) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.112.1.28 · Cited by 46 · see citing works
Kim, M., Kim, S. N., Lee, S., Byun, M. S., Shin, K. S., Park, H. Y., Jang, J. H., & Kwon, J. S. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.02.012 · Cited by 46 · see citing works
Janhunen, S. K., Svärd, H., Talpos, J., Kumar, G., Steckler, T., Plath, N., Lerdrup, L., Ruby, T., Haman, M., Wyler, R., et al. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3954-6 · Cited by 43 · see citing works
Selemon, L. D., Ceritoglu, C., Ratnanather, J. T., Wang, L., Harms, M. P., Aldridge, K., Begović, A., Csernansky, J. G., Miller, M. I., & Rakic, P. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23217 · Cited by 41 · see citing works
Rolls, E. T. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.017 · Cited by 39 · see citing works
Rahman, T., Zavitsanou, K., Purves-Tyson, T., Harms, L. R., Meehan, C., Schall, U., Todd, J., Hodgson, D. M., Michie, P. T., & Weickert, C. S. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00077 · Cited by 39 · see citing works
Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Makoto Miyauchi, C., Sassa, Y., & Kawashima, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-01460-6 · Cited by 36 · see citing works
Gu, Z., Jiang, Q., Yuen, E. Y., & Yan, Z. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018853 · Cited by 35 · see citing works
Zhong, P., Qin, L., & Yan, Z. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa027 · Cited by 34 · see citing works
Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding
Auger, M. L., & Floresco, S. B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.022 · Cited by 28 · see citing works
Wanke, N., & Schwabe, L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhz298 · Cited by 28 · see citing works
Zierhut, K. C., Schulte-Kemna, A., Kaufmann, J., Steiner, J., Bogerts, B., & Schiltz, K. (2013) · Cortex · doi:10.1016/j.cortex.2012.08.027 · Cited by 26 · see citing works
Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure
Wang, X., Gu, Z., Zhong, P., Chen, G., Feng, J., & Yan, Z. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.08.018 · Cited by 16 · see citing works
Sakamoto, K., Katori, Y., Saito, N., Yoshida, S., Aihara, K., & Mushiake, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080906 · Cited by 13 · see citing works
Modeling excess striatal D2 receptors in mice
Kellendonk, C. (2009) · Progress in Brain Research · doi:10.1016/s0079-6123(09)17907-4 · Cited by 10 · see citing works
- Authors
- Goldman‐Rakic, P. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Patricia S. Goldman‐Rakic
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 1994-11-01
- Volume
- 6
- Issue
- 4
- Pages
- 348-357
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2043941998
- Cited by
- 1,068
- References
- 49
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 20 · 2021: 21 · 2020: 18 · 2019: 50 · 2018: 29 · 2017: 37 · 2016: 30 · 2015: 50 · 2014: 31 · 2013: 60 · 2012: 48
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- working memory, schizophrenia, prefrontal cortex, thought disorder, cognitive impairment, non-human primates, brain injury, mental representation, prefrontal function
- MeSH terms
- Animals, Brain Mapping, Frontal Lobe, Humans, Neuropsychological Tests, Mental Recall, Retention, Psychology, Schizophrenia, Schizophrenic Psychology, Thinking, Prefrontal Cortex
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