Cited by 652Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Meyer-Lindenberg, Andreas, Miletich, Robert S., Kohn, Philip D., Esposito, Giuseppe, Carson, Richard E., Quarantelli, Mario, Weinberger, Daniel R., Berman, Karen Faith·2002·Nature Neuroscience

Abstract

Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant Ki in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.

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Crossref · 10.1038/nn804

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  • In individuals with a schizophrenia diagnosis, dopamine activity in the prefrontal cortex appears to be reduced.

    “Furthermore, in line with the effects of chronic stress, dopamine activity in the prefrontal cortex appears to be reduced in individuals with a schizophrenia diagnosis [132-134] .”

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Authors
Meyer-Lindenberg, A., Miletich, R. S., Kohn, P. D., Esposito, G., Carson, R. E., Quarantelli, M., Weinberger, D. R., & Berman, K. F.
Affiliations
National Institutes of Health (US)
Venue
Nature Neuroscience
Published
2002-01-28
Volume
5
Issue
3
Pages
267-271
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2004729128
Cited by
652
References
50
Citations by year
2026: 8 · 2025: 14 · 2024: 13 · 2023: 9 · 2022: 15 · 2021: 30 · 2020: 16 · 2019: 32 · 2018: 20 · 2017: 25 · 2016: 31 · 2015: 41 · 2014: 35 · 2013: 38 · 2012: 40
FWCI
19.67
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
schizophrenia, prefrontal cortex, striatum, dopamine signaling, dopamine uptake, regional cerebral blood flow, Wisconsin Card Sorting Test, prefrontal cortex activation
MeSH terms
Cerebrovascular Circulation, Corpus Striatum, Dihydroxyphenylalanine, Dopamine, Fluorine Radioisotopes, Humans, Neuropsychological Tests, Schizophrenia, Statistics as Topic, Synapses, Tomography, Emission-Computed, Prefrontal Cortex

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